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Identification of critical residues in the hemagglutinin and neuraminidase of influenza virus H1N1pdm for vaccine virus replication in embryonated chicken eggs.

Wang W, Lu J, Cotter CR, Wen K, Jin H, Chen Z.

J Virol. 2013 Apr;87(8):4642-9. doi: 10.1128/JVI.03271-12. Epub 2013 Feb 13.


The impact of key amino acid substitutions in the hemagglutinin of influenza A (H3N2) viruses on vaccine production and antibody response.

Chen Z, Zhou H, Jin H.

Vaccine. 2010 May 28;28(24):4079-85. doi: 10.1016/j.vaccine.2010.03.078.


Development of a high-yield live attenuated H7N9 influenza virus vaccine that provides protection against homologous and heterologous H7 wild-type viruses in ferrets.

Chen Z, Baz M, Lu J, Paskel M, Santos C, Subbarao K, Jin H, Matsuoka Y.

J Virol. 2014 Jun;88(12):7016-23. doi: 10.1128/JVI.00100-14. Epub 2014 Apr 9.


Increase in viral yield in eggs and MDCK cells of reassortant H5N1 vaccine candidate viruses caused by insertion of 38 amino acids into the NA stalk.

Zhang W, Xue T, Wu X, Zhang P, Zhao G, Peng D, Hu S, Wang X, Liu X, Liu W, Liu X.

Vaccine. 2011 Oct 19;29(45):8032-41. doi: 10.1016/j.vaccine.2011.08.054. Epub 2011 Aug 22.


The PB1 segment of an influenza A virus H1N1 2009pdm isolate enhances the replication efficiency of specific influenza vaccine strains in cell culture and embryonated eggs.

Mostafa A, Kanrai P, Ziebuhr J, Pleschka S.

J Gen Virol. 2016 Mar;97(3):620-31. doi: 10.1099/jgv.0.000390. Epub 2016 Jan 7.


Generation of live attenuated novel influenza virus A/California/7/09 (H1N1) vaccines with high yield in embryonated chicken eggs.

Chen Z, Wang W, Zhou H, Suguitan AL Jr, Shambaugh C, Kim L, Zhao J, Kemble G, Jin H.

J Virol. 2010 Jan;84(1):44-51. doi: 10.1128/JVI.02106-09.


Improving influenza virus backbones by including terminal regions of MDCK-adapted strains on hemagglutinin and neuraminidase gene segments.

Gomila RC, Suphaphiphat P, Judge C, Spencer T, Ferrari A, Wen Y, Palladino G, Dormitzer PR, Mason PW.

Vaccine. 2013 Oct 1;31(42):4736-43. doi: 10.1016/j.vaccine.2013.08.026. Epub 2013 Aug 20.


Protective efficacy of intranasal cold-adapted influenza A/New Caledonia/20/99 (H1N1) vaccines comprised of egg- or cell culture-derived reassortants.

Palker T, Kiseleva I, Johnston K, Su Q, Toner T, Szymkowiak C, Kwan WS, Rubin B, Petrukhin L, Wlochowski J, Monteiro J, Kraiouchkine N, DiStefano D, Rudenko L, Shaw A, Youil R.

Virus Res. 2004 Oct;105(2):183-94.


Improvement of influenza vaccine strain A/Vietnam/1194/2004 (H5N1) growth with the neuraminidase packaging sequence from A/Puerto Rico/8/34.

Pan W, Dong Z, Meng W, Zhang W, Li T, Li C, Zhang B, Chen L.

Hum Vaccin Immunother. 2012 Feb;8(2):252-9. doi: 10.4161/hv.18468. Epub 2012 Feb 1.


Generation of recombinant pandemic H1N1 influenza virus with the HA cleavable by bromelain and identification of the residues influencing HA bromelain cleavage.

Wang W, Suguitan AL Jr, Zengel J, Chen Z, Jin H.

Vaccine. 2012 Jan 20;30(5):872-8. doi: 10.1016/j.vaccine.2011.11.101. Epub 2011 Dec 13.


A live attenuated H7N7 candidate vaccine virus induces neutralizing antibody that confers protection from challenge in mice, ferrets, and monkeys.

Min JY, Vogel L, Matsuoka Y, Lu B, Swayne D, Jin H, Kemble G, Subbarao K.

J Virol. 2010 Nov;84(22):11950-60. doi: 10.1128/JVI.01305-10. Epub 2010 Sep 1.


Evaluation of three live attenuated H2 pandemic influenza vaccine candidates in mice and ferrets.

Chen GL, Lamirande EW, Cheng X, Torres-Velez F, Orandle M, Jin H, Kemble G, Subbarao K.

J Virol. 2014 Mar;88(5):2867-76. doi: 10.1128/JVI.01829-13. Epub 2013 Dec 26.


Isolation of the pandemic (H1N1) 2009 virus and its reassortant with an H3N2 swine influenza virus from healthy weaning pigs in Thailand in 2011.

Hiromoto Y, Parchariyanon S, Ketusing N, Netrabukkana P, Hayashi T, Kobayashi T, Takemae N, Saito T.

Virus Res. 2012 Oct;169(1):175-81. doi: 10.1016/j.virusres.2012.07.025. Epub 2012 Aug 10.


Evaluation of the attenuation, immunogenicity, and efficacy of a live virus vaccine generated by codon-pair bias de-optimization of the 2009 pandemic H1N1 influenza virus, in ferrets.

Broadbent AJ, Santos CP, Anafu A, Wimmer E, Mueller S, Subbarao K.

Vaccine. 2016 Jan 20;34(4):563-570. doi: 10.1016/j.vaccine.2015.11.054. Epub 2015 Dec 2.


Optimization of influenza A vaccine virus by reverse genetic using chimeric HA and NA genes with an extended PR8 backbone.

Medina J, Boukhebza H, De Saint Jean A, Sodoyer R, Legastelois I, Moste C.

Vaccine. 2015 Aug 20;33(35):4221-7. doi: 10.1016/j.vaccine.2015.06.112. Epub 2015 Jul 21.


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