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An inverse switch in DNA base excision and strand break repair contributes to melphalan resistance in multiple myeloma cells.

Sousa MM, Zub KA, Aas PA, Hanssen-Bauer A, Demirovic A, Sarno A, Tian E, Liabakk NB, Slupphaug G.

PLoS One. 2013;8(2):e55493. doi: 10.1371/journal.pone.0055493. Epub 2013 Feb 6.


The FA/BRCA pathway is involved in melphalan-induced DNA interstrand cross-link repair and accounts for melphalan resistance in multiple myeloma cells.

Chen Q, Van der Sluis PC, Boulware D, Hazlehurst LA, Dalton WS.

Blood. 2005 Jul 15;106(2):698-705. Epub 2005 Mar 31.


Evidence for different mechanisms of 'unhooking' for melphalan and cisplatin-induced DNA interstrand cross-links in vitro and in clinical acquired resistant tumour samples.

Spanswick VJ, Lowe HL, Newton C, Bingham JP, Bagnobianchi A, Kiakos K, Craddock C, Ledermann JA, Hochhauser D, Hartley JA.

BMC Cancer. 2012 Sep 28;12:436. doi: 10.1186/1471-2407-12-436.


Targeting abnormal DNA double-strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias.

Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, Rassool FV.

Oncogene. 2013 Apr 4;32(14):1784-93. doi: 10.1038/onc.2012.203. Epub 2012 May 28.


Repair of DNA interstrand crosslinks as a mechanism of clinical resistance to melphalan in multiple myeloma.

Spanswick VJ, Craddock C, Sekhar M, Mahendra P, Shankaranarayana P, Hughes RG, Hochhauser D, Hartley JA.

Blood. 2002 Jul 1;100(1):224-9.


Human monocytes undergo excessive apoptosis following temozolomide activating the ATM/ATR pathway while dendritic cells and macrophages are resistant.

Bauer M, Goldstein M, Heylmann D, Kaina B.

PLoS One. 2012;7(6):e39956. doi: 10.1371/journal.pone.0039956. Epub 2012 Jun 29.


In vitro evidence for homologous recombinational repair in resistance to melphalan.

Wang ZM, Chen ZP, Xu ZY, Christodoulopoulos G, Bello V, Mohr G, Aloyz R, Panasci LC.

J Natl Cancer Inst. 2001 Oct 3;93(19):1473-8.


Sensitization to radiation and alkylating agents by inhibitors of poly(ADP-ribose) polymerase is enhanced in cells deficient in DNA double-strand break repair.

Löser DA, Shibata A, Shibata AK, Woodbine LJ, Jeggo PA, Chalmers AJ.

Mol Cancer Ther. 2010 Jun;9(6):1775-87. doi: 10.1158/1535-7163.MCT-09-1027. Epub 2010 Jun 8.


Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.

Nikolova T, Ensminger M, Löbrich M, Kaina B.

DNA Repair (Amst). 2010 Oct 5;9(10):1050-63. doi: 10.1016/j.dnarep.2010.07.005. Epub 2010 Aug 13.


Genotypic and phenotypic comparisons of de novo and acquired melphalan resistance in an isogenic multiple myeloma cell line model.

Hazlehurst LA, Enkemann SA, Beam CA, Argilagos RF, Painter J, Shain KH, Saporta S, Boulware D, Moscinski L, Alsina M, Dalton WS.

Cancer Res. 2003 Nov 15;63(22):7900-6.


Functional analysis of the involvement of apurinic/apyrimidinic endonuclease 1 in the resistance to melphalan in multiple myeloma.

Xie J, Zhang L, Li M, Du J, Zhou L, Yang S, Zeng L, Li Z, Wang G, Wang D.

BMC Cancer. 2014 Jan 8;14:11. doi: 10.1186/1471-2407-14-11.


Interleukin-6 affects melphalan-induced DNA damage and repair in human multiple myeloma cells.

Efferth T, Fabry U, Osieka R.

Anticancer Res. 2002 Jan-Feb;22(1A):231-4.


Poly(ADP-Ribose) polymerase-1 and DNA-dependent protein kinase have equivalent roles in double strand break repair following ionizing radiation.

Mitchell J, Smith GC, Curtin NJ.

Int J Radiat Oncol Biol Phys. 2009 Dec 1;75(5):1520-7. doi: 10.1016/j.ijrobp.2009.07.1722.


Knockdown of DEPTOR inhibits cell proliferation and increases chemosensitivity to melphalan in human multiple myeloma RPMI-8226 cells via inhibiting PI3K/AKT activity.

Zhang HR, Chen JM, Zeng ZY, Que WZ.

J Int Med Res. 2013 Jun;41(3):584-95. doi: 10.1177/0300060513480920. Epub 2013 Apr 15.


PARP-1 and Ku compete for repair of DNA double strand breaks by distinct NHEJ pathways.

Wang M, Wu W, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G.

Nucleic Acids Res. 2006;34(21):6170-82. Epub 2006 Nov 6.


Deregulation of DNA double-strand break repair in multiple myeloma: implications for genome stability.

Herrero AB, San Miguel J, Gutierrez NC.

PLoS One. 2015 Mar 19;10(3):e0121581. doi: 10.1371/journal.pone.0121581. eCollection 2015.


[Effect of PARP1 inhibitor PJ34 on multi-drug resistance in human multiple myeloma cell line and its relationship with FA/BRCA pathway].

Xiong T, Wei H, Chen X, Xiao H.

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2014 Jun;31(3):312-6. doi: 10.3760/cma.j.issn.1003-9406.2014.03.012. Chinese.


Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

Liu X, Han EK, Anderson M, Shi Y, Semizarov D, Wang G, McGonigal T, Roberts L, Lasko L, Palma J, Zhu GD, Penning T, Rosenberg S, Giranda VL, Luo Y, Leverson J, Johnson EF, Shoemaker AR.

Mol Cancer Res. 2009 Oct;7(10):1686-92. doi: 10.1158/1541-7786.MCR-09-0299. Epub 2009 Oct 13.


Replication and homologous recombination repair regulate DNA double-strand break formation by the antitumor alkylator ecteinascidin 743.

Soares DG, Escargueil AE, Poindessous V, Sarasin A, de Gramont A, Bonatto D, Henriques JA, Larsen AK.

Proc Natl Acad Sci U S A. 2007 Aug 7;104(32):13062-7. Epub 2007 Jul 26.

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