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Items: 1 to 20 of 106


Lactate dehydrogenase A is overexpressed in pancreatic cancer and promotes the growth of pancreatic cancer cells.

Rong Y, Wu W, Ni X, Kuang T, Jin D, Wang D, Lou W.

Tumour Biol. 2013 Jun;34(3):1523-30. doi: 10.1007/s13277-013-0679-1. Epub 2013 Feb 13.


Inhibition of LDHA suppresses tumor progression in prostate cancer.

Xian ZY, Liu JM, Chen QK, Chen HZ, Ye CJ, Xue J, Yang HQ, Li JL, Liu XF, Kuang SJ.

Tumour Biol. 2015 Sep;36(10):8093-100. doi: 10.1007/s13277-015-3540-x. Epub 2015 May 16.


A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer.

Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K.

Clin Cancer Res. 2014 Aug 15;20(16):4370-80. doi: 10.1158/1078-0432.CCR-14-0186. Epub 2014 Jun 19.


FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression.

Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K.

Clin Cancer Res. 2014 May 15;20(10):2595-606. doi: 10.1158/1078-0432.CCR-13-2407. Epub 2014 Mar 14.


LDHA is necessary for the tumorigenicity of esophageal squamous cell carcinoma.

Yao F, Zhao T, Zhong C, Zhu J, Zhao H.

Tumour Biol. 2013 Feb;34(1):25-31. doi: 10.1007/s13277-012-0506-0. Epub 2012 Sep 8.


The c-Myc-LDHA axis positively regulates aerobic glycolysis and promotes tumor progression in pancreatic cancer.

He TL, Zhang YJ, Jiang H, Li XH, Zhu H, Zheng KL.

Med Oncol. 2015 Jul;32(7):187. doi: 10.1007/s12032-015-0633-8. Epub 2015 May 29.


RNAi-mediated gene silencing of vascular endothelial growth factor-C inhibits tumor lymphangiogenesis and growth of gastric cancer in vivo in mice.

Yao J, Da M, Guo T, Duan Y, Zhang Y.

Tumour Biol. 2013 Jun;34(3):1493-501. doi: 10.1007/s13277-013-0674-6. Epub 2013 Mar 10.


Epigenetic silencing of EYA2 in pancreatic adenocarcinomas promotes tumor growth.

Vincent A, Hong SM, Hu C, Omura N, Young A, Kim H, Yu J, Knight S, Ayars M, Griffith M, Van Seuningen I, Maitra A, Goggins M.

Oncotarget. 2014 May 15;5(9):2575-87.


Overexpression of lactate dehydrogenase-A in human intrahepatic cholangiocarcinoma: its implication for treatment.

Yu Y, Liao M, Liu R, Chen J, Feng H, Fu Z.

World J Surg Oncol. 2014 Mar 31;12:78. doi: 10.1186/1477-7819-12-78.


Knockdown of lactate dehydrogenase A suppresses tumor growth and metastasis of human hepatocellular carcinoma.

Sheng SL, Liu JJ, Dai YH, Sun XG, Xiong XP, Huang G.

FEBS J. 2012 Oct;279(20):3898-910. doi: 10.1111/j.1742-4658.2012.08748.x. Epub 2012 Sep 13.


Therapeutic Targeting of the Warburg Effect in Pancreatic Cancer Relies on an Absence of p53 Function.

Rajeshkumar NV, Dutta P, Yabuuchi S, de Wilde RF, Martinez GV, Le A, Kamphorst JJ, Rabinowitz JD, Jain SK, Hidalgo M, Dang CV, Gillies RJ, Maitra A.

Cancer Res. 2015 Aug 15;75(16):3355-64. doi: 10.1158/0008-5472.CAN-15-0108. Epub 2015 Jun 25.


Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression.

Le A, Cooper CR, Gouw AM, Dinavahi R, Maitra A, Deck LM, Royer RE, Vander Jagt DL, Semenza GL, Dang CV.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2037-42. doi: 10.1073/pnas.0914433107. Epub 2010 Jan 19.


The effect of HIF-1α on glucose metabolism, growth and apoptosis of pancreatic cancerous cells.

He G, Jiang Y, Zhang B, Wu G.

Asia Pac J Clin Nutr. 2014;23(1):174-80. doi: 10.6133/apjcn.2014.23.1.14.


Pharmacological or genetic inhibition of LDHA reverses tumor progression of pediatric osteosarcoma.

Gao S, Tu DN, Li H, Jiang JX, Cao X, You JB, Zhou XQ.

Biomed Pharmacother. 2016 Jul;81:388-93. doi: 10.1016/j.biopha.2016.04.029. Epub 2016 Apr 26.


Stromal-derived factor-1α/CXCL12-CXCR4 chemotactic pathway promotes perineural invasion in pancreatic cancer.

Xu Q, Wang Z, Chen X, Duan W, Lei J, Zong L, Li X, Sheng L, Ma J, Han L, Li W, Zhang L, Guo K, Ma Z, Wu Z, Wu E, Ma Q.

Oncotarget. 2015 Mar 10;6(7):4717-32.


Downregulation of glypican-3 expression increases migration, invasion, and tumorigenicity of human ovarian cancer cells.

Liu Y, Zheng D, Liu M, Bai J, Zhou X, Gong B, Lü J, Zhang Y, Huang H, Luo W, Huang G.

Tumour Biol. 2015 Sep;36(10):7997-8006. doi: 10.1007/s13277-015-3528-6. Epub 2015 May 14.


Suppression of lactate dehydrogenase A compromises tumor progression by downregulation of the Warburg effect in glioblastoma.

Li J, Zhu S, Tong J, Hao H, Yang J, Liu Z, Wang Y.

Neuroreport. 2016 Jan 20;27(2):110-5. doi: 10.1097/WNR.0000000000000506.


Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.

Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W.

Acta Biochim Biophys Sin (Shanghai). 2017 Feb 6;49(2):119-127. doi: 10.1093/abbs/gmw124.


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