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Sputum mediator profiling and relationship to airway wall geometry imaging in severe asthma.

Desai D, Gupta S, Siddiqui S, Singapuri A, Monteiro W, Entwisle J, Visvanathan S, Parmar H, Kajekar R, Brightling CE.

Respir Res. 2013 Feb 11;14:17. doi: 10.1186/1465-9921-14-17.


Quantitative analysis of high-resolution computed tomography scans in severe asthma subphenotypes.

Gupta S, Siddiqui S, Haldar P, Entwisle JJ, Mawby D, Wardlaw AJ, Bradding P, Pavord ID, Green RH, Brightling CE.

Thorax. 2010 Sep;65(9):775-81. doi: 10.1136/thx.2010.136374.


Detailed analysis of sputum and systemic inflammation in asthma phenotypes: are paucigranulocytic asthmatics really non-inflammatory?

Demarche S, Schleich F, Henket M, Paulus V, Van Hees T, Louis R.

BMC Pulm Med. 2016 Apr 5;16:46. doi: 10.1186/s12890-016-0208-2.


CT-assessed large airway involvement and lung function decline in eosinophilic asthma: The association between induced sputum eosinophil differential counts and airway remodeling.

Inoue H, Ito I, Niimi A, Matsumoto H, Matsuoka H, Jinnai M, Takeda T, Oguma T, Otsuka K, Nakaji H, Tajiri T, Iwata T, Nagasaki T, Kanemitsu Y, Mishima M.

J Asthma. 2016 Nov;53(9):914-21. doi: 10.3109/02770903.2016.1167903. Epub 2016 Apr 26.


Anti-inflammatory deficiencies in neutrophilic asthma: reduced galectin-3 and IL-1RA/IL-1β.

Gao P, Gibson PG, Baines KJ, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Zhang J, Simpson JL.

Respir Res. 2015 Jan 24;16:5. doi: 10.1186/s12931-014-0163-5.


Asthma and natural colds. Inflammatory indices in induced sputum: a feasibility study.

Pizzichini MM, Pizzichini E, Efthimiadis A, Chauhan AJ, Johnston SL, Hussack P, Mahony J, Dolovich J, Hargreave FE.

Am J Respir Crit Care Med. 1998 Oct;158(4):1178-84.


Smoking and airway inflammation in patients with mild asthma.

Chalmers GW, MacLeod KJ, Thomson L, Little SA, McSharry C, Thomson NC.

Chest. 2001 Dec;120(6):1917-22.


Potentially pathogenic airway bacteria and neutrophilic inflammation in treatment resistant severe asthma.

Green BJ, Wiriyachaiporn S, Grainge C, Rogers GB, Kehagia V, Lau L, Carroll MP, Bruce KD, Howarth PH.

PLoS One. 2014 Jun 23;9(6):e100645. doi: 10.1371/journal.pone.0100645. eCollection 2014.


[Airway remodeling assessed by high-resolution computed tomography in patients with asthma: relationship to biological markers in induced sputum].

Wu SM, Li CE, Cai RP, Zhang Q, Xu YJ.

Zhonghua Jie He He Hu Xi Za Zhi. 2012 Dec;35(12):892-6. Chinese.


Analyses of asthma severity phenotypes and inflammatory proteins in subjects stratified by sputum granulocytes.

Hastie AT, Moore WC, Meyers DA, Vestal PL, Li H, Peters SP, Bleecker ER; National Heart, Lung, and Blood Institute Severe Asthma Research Program.

J Allergy Clin Immunol. 2010 May;125(5):1028-1036.e13. doi: 10.1016/j.jaci.2010.02.008. Epub 2010 Apr 15.


Airway inflammation assessed by invasive and noninvasive means in severe asthma: eosinophilic and noneosinophilic phenotypes.

Lemière C, Ernst P, Olivenstein R, Yamauchi Y, Govindaraju K, Ludwig MS, Martin JG, Hamid Q.

J Allergy Clin Immunol. 2006 Nov;118(5):1033-9. Epub 2006 Sep 25.


Quantitative computed tomography-derived clusters: redefining airway remodeling in asthmatic patients.

Gupta S, Hartley R, Khan UT, Singapuri A, Hargadon B, Monteiro W, Pavord ID, Sousa AR, Marshall RP, Subramanian D, Parr D, Entwisle JJ, Siddiqui S, Raj V, Brightling CE.

J Allergy Clin Immunol. 2014 Mar;133(3):729-38.e18. doi: 10.1016/j.jaci.2013.09.039. Epub 2013 Nov 12.


Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.


Exhaled matrix metalloproteinase-9 (MMP-9) in different biological phenotypes of asthma.

Barbaro MP, Spanevello A, Palladino GP, Salerno FG, Lacedonia D, Carpagnano GE.

Eur J Intern Med. 2014 Jan;25(1):92-6. doi: 10.1016/j.ejim.2013.08.705. Epub 2013 Sep 23.


Characterization of sputum biomarkers for asthma-COPD overlap syndrome.

Gao J, Iwamoto H, Koskela J, Alenius H, Hattori N, Kohno N, Laitinen T, Mazur W, Pulkkinen V.

Int J Chron Obstruct Pulmon Dis. 2016 Sep 30;11:2457-2465. eCollection 2016. Erratum in: Int J Chron Obstruct Pulmon Dis. 2017 Apr 18;12 :1191.


Exacerbation risk in severe asthma is stratified by inflammatory phenotype using longitudinal measures of sputum eosinophils.

Walsh CJ, Zaihra T, Benedetti A, Fugère C, Olivenstein R, Lemière C, Hamid Q, Martin JG.

Clin Exp Allergy. 2016 Oct;46(10):1291-302. doi: 10.1111/cea.12762. Epub 2016 Jun 27.


Low interleukin (IL)-18 levels in sputum supernatants of patients with severe refractory asthma.

Rovina N, Dima E, Bakakos P, Tseliou E, Kontogianni K, Papiris S, Koutsoukou A, Koulouris NG, Loukides S.

Respir Med. 2015 May;109(5):580-7. doi: 10.1016/j.rmed.2015.03.002. Epub 2015 Mar 19.


Expiratory flows and airway inflammation in elderly asthmatic patients.

Ducharme ME, Prince P, Hassan N, Nair P, Boulet LP.

Respir Med. 2011 Sep;105(9):1284-9. doi: 10.1016/j.rmed.2011.04.006. Epub 2011 May 4.


Full blood count parameters for the detection of asthma inflammatory phenotypes.

Zhang XY, Simpson JL, Powell H, Yang IA, Upham JW, Reynolds PN, Hodge S, James AL, Jenkins C, Peters MJ, Lin JT, Gibson PG.

Clin Exp Allergy. 2014 Sep;44(9):1137-45. doi: 10.1111/cea.12345.


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