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Items: 1 to 20 of 89

1.

Site-specific interaction between α-synuclein and membranes probed by NMR-observed methionine oxidation rates.

Maltsev AS, Chen J, Levine RL, Bax A.

J Am Chem Soc. 2013 Feb 27;135(8):2943-6. doi: 10.1021/ja312415q. Epub 2013 Feb 14.

2.

UV-induced selective oxidation of Met5 to Met-sulfoxide leads to the formation of neurotoxic fibril-incompetent α-synuclein oligomers.

Carmo-Gonçalves P, Pinheiro AS, Romão L, Cortines J, Follmer C.

Amyloid. 2014 Sep;21(3):163-74. doi: 10.3109/13506129.2014.912208. Epub 2014 Apr 30.

PMID:
24784227
3.

Role of N-terminal methionine residues in the redox activity of copper bound to alpha-synuclein.

Rodríguez EE, Arcos-López T, Trujano-Ortiz LG, Fernández CO, González FJ, Vela A, Quintanar L.

J Biol Inorg Chem. 2016 Sep;21(5-6):691-702. doi: 10.1007/s00775-016-1376-5. Epub 2016 Jul 15.

PMID:
27422629
4.

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites.

Binolfi A, Limatola A, Verzini S, Kosten J, Theillet FX, Rose HM, Bekei B, Stuiver M, van Rossum M, Selenko P.

Nat Commun. 2016 Jan 25;7:10251. doi: 10.1038/ncomms10251.

5.

Solid-state ¹³C NMR reveals annealing of raft-like membranes containing cholesterol by the intrinsically disordered protein α-Synuclein.

Leftin A, Job C, Beyer K, Brown MF.

J Mol Biol. 2013 Aug 23;425(16):2973-87. doi: 10.1016/j.jmb.2013.04.002. Epub 2013 Apr 11.

6.

Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.

Bodner CR, Dobson CM, Bax A.

J Mol Biol. 2009 Jul 24;390(4):775-90. doi: 10.1016/j.jmb.2009.05.066. Epub 2009 May 27.

7.

N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

Bartels T, Kim NC, Luth ES, Selkoe DJ.

PLoS One. 2014 Jul 30;9(7):e103727. doi: 10.1371/journal.pone.0103727. eCollection 2014.

8.

Copper(I) Forms a Redox-Stable 1:2 Complex with α-Synuclein N-Terminal Peptide in a Membrane-Like Environment.

Dell'Acqua S, Pirota V, Monzani E, Camponeschi F, De Ricco R, Valensin D, Casella L.

Inorg Chem. 2016 Jun 20;55(12):6100-6. doi: 10.1021/acs.inorgchem.6b00641. Epub 2016 Jun 3.

PMID:
27259006
9.

N-terminal acetylation stabilizes N-terminal helicity in lipid- and micelle-bound α-synuclein and increases its affinity for physiological membranes.

Dikiy I, Eliezer D.

J Biol Chem. 2014 Feb 7;289(6):3652-65. doi: 10.1074/jbc.M113.512459. Epub 2013 Dec 12.

10.

Site-specific copper-catalyzed oxidation of α-synuclein: tightening the link between metal binding and protein oxidative damage in Parkinson's disease.

Miotto MC, Rodriguez EE, Valiente-Gabioud AA, Torres-Monserrat V, Binolfi A, Quintanar L, Zweckstetter M, Griesinger C, Fernández CO.

Inorg Chem. 2014 May 5;53(9):4350-8. doi: 10.1021/ic4031377. Epub 2014 Apr 11.

PMID:
24725094
11.

Alpha-synuclein can function as an antioxidant preventing oxidation of unsaturated lipid in vesicles.

Zhu M, Qin ZJ, Hu D, Munishkina LA, Fink AL.

Biochemistry. 2006 Jul 4;45(26):8135-42.

PMID:
16800638
12.

Exploring the structural details of Cu(I) binding to α-synuclein by NMR spectroscopy.

Binolfi A, Valiente-Gabioud AA, Duran R, Zweckstetter M, Griesinger C, Fernandez CO.

J Am Chem Soc. 2011 Jan 19;133(2):194-6. doi: 10.1021/ja107842f. Epub 2010 Dec 15.

PMID:
21158432
13.

Direct observation of the three regions in α-synuclein that determine its membrane-bound behaviour.

Fusco G, De Simone A, Gopinath T, Vostrikov V, Vendruscolo M, Dobson CM, Veglia G.

Nat Commun. 2014 May 29;5:3827. doi: 10.1038/ncomms4827.

14.

The Impact of N-terminal Acetylation of α-Synuclein on Phospholipid Membrane Binding and Fibril Structure.

Iyer A, Roeters SJ, Schilderink N, Hommersom B, Heeren RM, Woutersen S, Claessens MM, Subramaniam V.

J Biol Chem. 2016 Sep 30;291(40):21110-21122. Epub 2016 Aug 16.

15.

Helical alpha-synuclein forms highly conductive ion channels.

Zakharov SD, Hulleman JD, Dutseva EA, Antonenko YN, Rochet JC, Cramer WA.

Biochemistry. 2007 Dec 18;46(50):14369-79. Epub 2007 Nov 22.

PMID:
18031063
16.

Role of individual methionines in the fibrillation of methionine-oxidized alpha-synuclein.

Hokenson MJ, Uversky VN, Goers J, Yamin G, Munishkina LA, Fink AL.

Biochemistry. 2004 Apr 20;43(15):4621-33.

PMID:
15078109
17.

Nuclear Magnetic Resonance Observation of α-Synuclein Membrane Interaction by Monitoring the Acetylation Reactivity of Its Lysine Side Chains.

Lee JH, Ying J, Bax A.

Biochemistry. 2016 Sep 6;55(35):4949-59. doi: 10.1021/acs.biochem.6b00637. Epub 2016 Aug 23.

18.

Structural Ensembles of Membrane-bound α-Synuclein Reveal the Molecular Determinants of Synaptic Vesicle Affinity.

Fusco G, De Simone A, Arosio P, Vendruscolo M, Veglia G, Dobson CM.

Sci Rep. 2016 Jun 8;6:27125. doi: 10.1038/srep27125.

19.

Products of Cu(II)-catalyzed oxidation of the N-terminal fragments of alpha-synuclein in the presence of hydrogen peroxide.

Kowalik-Jankowska T, Rajewska A, Jankowska E, Wiśniewska K, Grzonka Z.

J Inorg Biochem. 2006 Oct;100(10):1623-31. Epub 2006 Jun 6.

PMID:
16839607
20.

Characterization of methionine oxidation and methionine sulfoxide reduction using methionine-rich cysteine-free proteins.

Liang X, Kaya A, Zhang Y, Le DT, Hua D, Gladyshev VN.

BMC Biochem. 2012 Oct 23;13:21. doi: 10.1186/1471-2091-13-21.

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