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Items: 1 to 20 of 114

1.

EXTL2, a member of the EXT family of tumor suppressors, controls glycosaminoglycan biosynthesis in a xylose kinase-dependent manner.

Nadanaka S, Zhou S, Kagiyama S, Shoji N, Sugahara K, Sugihara K, Asano M, Kitagawa H.

J Biol Chem. 2013 Mar 29;288(13):9321-33. doi: 10.1074/jbc.M112.416909. Epub 2013 Feb 10.

PMID:
23395820
2.

EXTL2 controls liver regeneration and aortic calcification through xylose kinase-dependent regulation of glycosaminoglycan biosynthesis.

Nadanaka S, Kitagawa H.

Matrix Biol. 2014 Apr;35:18-24. doi: 10.1016/j.matbio.2013.10.010. Epub 2013 Oct 24. Review.

PMID:
24176719
4.

Biosynthesis of heparan sulfate in EXT1-deficient cells.

Okada M, Nadanaka S, Shoji N, Tamura J, Kitagawa H.

Biochem J. 2010 May 27;428(3):463-71. doi: 10.1042/BJ20100101.

PMID:
20377530
5.

Identification of phosphatase that dephosphorylates xylose in the glycosaminoglycan-protein linkage region of proteoglycans.

Koike T, Izumikawa T, Sato B, Kitagawa H.

J Biol Chem. 2014 Mar 7;289(10):6695-708. doi: 10.1074/jbc.M113.520536. Epub 2014 Jan 14.

PMID:
24425863
6.

Reduced Expression of EXTL2, a Member of the Exostosin (EXT) Family of Glycosyltransferases, in Human Embryonic Kidney 293 Cells Results in Longer Heparan Sulfate Chains.

Katta K, Imran T, Busse-Wicher M, Grønning M, Czajkowski S, Kusche-Gullberg M.

J Biol Chem. 2015 May 22;290(21):13168-77. doi: 10.1074/jbc.M114.631754. Epub 2015 Mar 31.

PMID:
25829497
7.

Roles of EXTL2, a member of the EXT family of tumour suppressors, in liver injury and regeneration processes.

Nadanaka S, Kagiyama S, Kitagawa H.

Biochem J. 2013 Aug 15;454(1):133-45. doi: 10.1042/BJ20130323.

PMID:
23734945
8.

Human tumor suppressor EXT gene family members EXTL1 and EXTL3 encode alpha 1,4- N-acetylglucosaminyltransferases that likely are involved in heparan sulfate/ heparin biosynthesis.

Kim BT, Kitagawa H, Tamura J, Saito T, Kusche-Gullberg M, Lindahl U, Sugahara K.

Proc Natl Acad Sci U S A. 2001 Jun 19;98(13):7176-81. Epub 2001 Jun 5.

PMID:
11390981
9.

rib-2, a Caenorhabditis elegans homolog of the human tumor suppressor EXT genes encodes a novel alpha1,4-N-acetylglucosaminyltransferase involved in the biosynthetic initiation and elongation of heparan sulfate.

Kitagawa H, Egusa N, Tamura JI, Kusche-Gullberg M, Lindahl U, Sugahara K.

J Biol Chem. 2001 Feb 16;276(7):4834-8. Epub 2000 Dec 19.

PMID:
11121397
10.

Contribution of EXT1, EXT2, and EXTL3 to heparan sulfate chain elongation.

Busse M, Feta A, Presto J, Wilén M, Grønning M, Kjellén L, Kusche-Gullberg M.

J Biol Chem. 2007 Nov 9;282(45):32802-10. Epub 2007 Aug 29.

PMID:
17761672
11.

FAM20B is a kinase that phosphorylates xylose in the glycosaminoglycan-protein linkage region.

Koike T, Izumikawa T, Tamura J, Kitagawa H.

Biochem J. 2009 Jun 26;421(2):157-62. doi: 10.1042/BJ20090474.

PMID:
19473117
12.

GlcUAβ1-3Galβ1-3Galβ1-4Xyl(2-O-phosphate) is the preferred substrate for chondroitin N-acetylgalactosaminyltransferase-1.

Izumikawa T, Sato B, Mikami T, Tamura J, Igarashi M, Kitagawa H.

J Biol Chem. 2015 Feb 27;290(9):5438-48. doi: 10.1074/jbc.M114.603266. Epub 2015 Jan 7.

PMID:
25568321
13.

The putative tumor suppressors EXT1 and EXT2 are glycosyltransferases required for the biosynthesis of heparan sulfate.

Lind T, Tufaro F, McCormick C, Lindahl U, Lidholt K.

J Biol Chem. 1998 Oct 9;273(41):26265-8.

PMID:
9756849
15.

Identification and characterization of a novel member of the EXT gene family, EXTL2.

Wuyts W, Van Hul W, Hendrickx J, Speleman F, Wauters J, De Boulle K, Van Roy N, Van Agtmael T, Bossuyt P, Willems PJ.

Eur J Hum Genet. 1997 Nov-Dec;5(6):382-9.

PMID:
9450183
16.

Assessment of glycosaminoglycan-protein linkage tetrasaccharides as acceptors for GalNAc- and GlcNAc-transferases from mouse mastocytoma.

Lidholt K, Fjelstad M, Lindahl U, Goto F, Ogawa T, Kitagawa H, Sugahara K.

Glycoconj J. 1997 Sep;14(6):737-42.

PMID:
9337087
17.

Sulfation of the galactose residues in the glycosaminoglycan-protein linkage region by recombinant human chondroitin 6-O-sulfotransferase-1.

Kitagawa H, Tsutsumi K, Ikegami-Kuzuhara A, Nadanaka S, Goto F, Ogawa T, Sugahara K.

J Biol Chem. 2008 Oct 10;283(41):27438-43. doi: 10.1074/jbc.M803279200. Epub 2008 Aug 11.

PMID:
18697746
18.

Distinct and collaborative roles of Drosophila EXT family proteins in morphogen signalling and gradient formation.

Han C, Belenkaya TY, Khodoun M, Tauchi M, Lin X, Lin X.

Development. 2004 Apr;131(7):1563-75. Epub 2004 Mar 3.

PMID:
14998928
19.

Mutation analysis of hereditary multiple exostoses in the Chinese.

Xu L, Xia J, Jiang H, Zhou J, Li H, Wang D, Pan Q, Long Z, Fan C, Deng HX.

Hum Genet. 1999 Jul-Aug;105(1-2):45-50.

PMID:
10480354
20.

Demonstration of a novel gene DEXT3 of Drosophila melanogaster as the essential N-acetylglucosamine transferase in the heparan sulfate biosynthesis: chain initiation and elongation.

Kim BT, Kitagawa H, Tamura Ji J, Kusche-Gullberg M, Lindahl U, Sugahara K.

J Biol Chem. 2002 Apr 19;277(16):13659-65. Epub 2002 Feb 6.

PMID:
11832488

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