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Items: 1 to 20 of 107

1.

Synthesis of tartaric acid analogues of FR258900 and their evaluation as glycogen phosphorylase inhibitors.

Varga G, Docsa T, Gergely P, Juhász L, Somsák L.

Bioorg Med Chem Lett. 2013 Mar 15;23(6):1789-92. doi: 10.1016/j.bmcl.2013.01.042. Epub 2013 Jan 22.

PMID:
23395662
2.

FR258900, a potential anti-hyperglycemic drug, binds at the allosteric site of glycogen phosphorylase.

Tiraidis C, Alexacou KM, Zographos SE, Leonidas DD, Gimisis T, Oikonomakos NG.

Protein Sci. 2007 Aug;16(8):1773-82. Epub 2007 Jun 28.

3.

The binding of β-d-glucopyranosyl-thiosemicarbazone derivatives to glycogen phosphorylase: A new class of inhibitors.

Alexacou KM, Tenchiu Deleanu AC, Chrysina ED, Charavgi MD, Kostas ID, Zographos SE, Oikonomakos NG, Leonidas DD.

Bioorg Med Chem. 2010 Nov 15;18(22):7911-22. doi: 10.1016/j.bmc.2010.09.039. Epub 2010 Sep 22.

PMID:
20947361
4.

Synthesis of 2-(β-D-glucopyranosylamino)-5-substituted-1,3,4-oxadiazoles for inhibition of glycogen phosphorylase.

Tóth M, Szőcs B, Kaszás T, Docsa T, Gergely P, Somsák L.

Carbohydr Res. 2013 Nov 15;381:196-204. doi: 10.1016/j.carres.2013.04.025. Epub 2013 Apr 27.

PMID:
23673237
5.

Discovery of novel dual-action antidiabetic agents that inhibit glycogen phosphorylase and activate glucokinase.

Zhang L, Chen X, Liu J, Zhu Q, Leng Y, Luo X, Jiang H, Liu H.

Eur J Med Chem. 2012 Dec;58:624-39. doi: 10.1016/j.ejmech.2012.06.020. Epub 2012 Jun 18.

PMID:
23178962
6.

Identification, synthesis, and characterization of new glycogen phosphorylase inhibitors binding to the allosteric AMP site.

Kristiansen M, Andersen B, Iversen LF, Westergaard N.

J Med Chem. 2004 Jul 1;47(14):3537-45.

PMID:
15214781
7.

Synthesis of N-(beta-D-glucopyranosyl) monoamides of dicarboxylic acids as potential inhibitors of glycogen phosphorylase.

Czifrák K, Hadady Z, Docsa T, Gergely P, Schmidt J, Wessjohann L, Somsák L.

Carbohydr Res. 2006 Jun 12;341(8):947-56. Epub 2006 Mar 29.

PMID:
16564511
8.

Synthesis of substituted 2-(β-D-glucopyranosyl)-benzimidazoles and their evaluation as inhibitors of glycogen phosphorylase.

Bokor É, Szilágyi E, Docsa T, Gergely P, Somsák L.

Carbohydr Res. 2013 Nov 15;381:179-86. doi: 10.1016/j.carres.2013.01.011. Epub 2013 Jan 29.

PMID:
23419607
9.

Glucopyranosylidene-spiro-iminothiazolidinone, a new bicyclic ring system: synthesis, derivatization, and evaluation for inhibition of glycogen phosphorylase by enzyme kinetic and crystallographic methods.

Czifrák K, Páhi A, Deák S, Kiss-Szikszai A, Kövér KE, Docsa T, Gergely P, Alexacou KM, Papakonstantinou M, Leonidas DD, Zographos SE, Chrysina ED, Somsák L.

Bioorg Med Chem. 2014 Aug 1;22(15):4028-41. doi: 10.1016/j.bmc.2014.05.076. Epub 2014 Jun 16.

PMID:
25009003
10.

Synthesis of N-(beta-D-glucopyranosyl)- and N-(2-acetamido-2-deoxy-beta-D-glucopyranosyl) amides as inhibitors of glycogen phosphorylase.

Györgydeák Z, Hadady Z, Felföldi N, Krakomperger A, Nagy V, Tóth M, Brunyánszki A, Docsa T, Gergely P, Somsák L.

Bioorg Med Chem. 2004 Sep 15;12(18):4861-70.

PMID:
15336265
11.

Crystallographic studies on acyl ureas, a new class of glycogen phosphorylase inhibitors, as potential antidiabetic drugs.

Oikonomakos NG, Kosmopoulou MN, Chrysina ED, Leonidas DD, Kostas ID, Wendt KU, Klabunde T, Defossa E.

Protein Sci. 2005 Jul;14(7):1760-71.

12.

Natural flavonoids as antidiabetic agents. The binding of gallic and ellagic acids to glycogen phosphorylase b.

Kyriakis E, Stravodimos GA, Kantsadi AL, Chatzileontiadou DS, Skamnaki VT, Leonidas DD.

FEBS Lett. 2015 Jul 8;589(15):1787-94. doi: 10.1016/j.febslet.2015.05.013. Epub 2015 May 14.

13.
14.

N-(4-Substituted-benzoyl)-N'-(β-d-glucopyranosyl)ureas as inhibitors of glycogen phosphorylase: Synthesis and evaluation by kinetic, crystallographic, and molecular modelling methods.

Nagy V, Felföldi N, Kónya B, Praly JP, Docsa T, Gergely P, Chrysina ED, Tiraidis C, Kosmopoulou MN, Alexacou KM, Konstantakaki M, Leonidas DD, Zographos SE, Oikonomakos NG, Kozmon S, Tvaroška I, Somsák L.

Bioorg Med Chem. 2012 Mar 1;20(5):1801-16. doi: 10.1016/j.bmc.2011.12.059. Epub 2012 Jan 20.

PMID:
22325154
15.

C-Glucosylated malonitrile as a key intermediate towards carbohydrate-based glycogen phosphorylase inhibitors.

Feuillastre S, Chajistamatiou AS, Potamitis C, Zervou M, Zoumpoulakis P, Chrysina ED, Praly JP, Vidal S.

Bioorg Med Chem. 2012 Sep 15;20(18):5592-9. doi: 10.1016/j.bmc.2012.07.033. Epub 2012 Aug 2.

PMID:
22910227
16.

Synthesis of C-xylopyranosyl- and xylopyranosylidene-spiro-heterocycles as potential inhibitors of glycogen phosphorylase.

Somsák L, Bokor É, Czibere B, Czifrák K, Koppány C, Kulcsár L, Kun S, Szilágyi E, Tóth M, Docsa T, Gergely P.

Carbohydr Res. 2014 Nov 18;399:38-48. doi: 10.1016/j.carres.2014.05.020. Epub 2014 Jun 4.

PMID:
25081322
17.

Binding of oxalyl derivatives of beta-d-glucopyranosylamine to muscle glycogen phosphorylase b.

Hadjiloi T, Tiraidis C, Chrysina ED, Leonidas DD, Oikonomakos NG, Tsipos P, Gimisis T.

Bioorg Med Chem. 2006 Jun 1;14(11):3872-82. Epub 2006 Feb 7.

PMID:
16464598
18.

Pentacyclic triterpenes. Part 2: Synthesis and biological evaluation of maslinic acid derivatives as glycogen phosphorylase inhibitors.

Wen X, Zhang P, Liu J, Zhang L, Wu X, Ni P, Sun H.

Bioorg Med Chem Lett. 2006 Feb;16(3):722-6. Epub 2005 Oct 21.

PMID:
16246555
19.

Modeling aided design of potent glycogen phosphorylase inhibitors.

Deng Q, Lu Z, Bohn J, Ellsworth KP, Myers RW, Geissler WM, Harris G, Willoughby CA, Chapman K, McKeever B, Mosley R.

J Mol Graph Model. 2005 Apr;23(5):457-64.

PMID:
15781188
20.

Identification of pentacyclic triterpenes derivatives as potent inhibitors against glycogen phosphorylase based on 3D-QSAR studies.

Liang Z, Zhang L, Li L, Liu J, Li H, Zhang L, Chen L, Cheng K, Zheng M, Wen X, Zhang P, Hao J, Gong Y, Zhang X, Zhu X, Chen J, Liu H, Jiang H, Luo C, Sun H.

Eur J Med Chem. 2011 Jun;46(6):2011-21. doi: 10.1016/j.ejmech.2011.02.053. Epub 2011 Feb 27.

PMID:
21439694

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