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Items: 1 to 20 of 93

1.

LRP6 enhances glucose metabolism by promoting TCF7L2-dependent insulin receptor expression and IGF receptor stabilization in humans.

Singh R, De Aguiar RB, Naik S, Mani S, Ostadsharif K, Wencker D, Sotoudeh M, Malekzadeh R, Sherwin RS, Mani A.

Cell Metab. 2013 Feb 5;17(2):197-209. doi: 10.1016/j.cmet.2013.01.009.

2.

Low density lipoprotein (LDL) receptor-related protein 6 (LRP6) regulates body fat and glucose homeostasis by modulating nutrient sensing pathways and mitochondrial energy expenditure.

Liu W, Singh R, Choi CS, Lee HY, Keramati AR, Samuel VT, Lifton RP, Shulman GI, Mani A.

J Biol Chem. 2012 Mar 2;287(10):7213-23. doi: 10.1074/jbc.M111.286724. Epub 2012 Jan 9.

3.

The combined hyperlipidemia caused by impaired Wnt-LRP6 signaling is reversed by Wnt3a rescue.

Go GW, Srivastava R, Hernandez-Ono A, Gang G, Smith SB, Booth CJ, Ginsberg HN, Mani A.

Cell Metab. 2014 Feb 4;19(2):209-20. doi: 10.1016/j.cmet.2013.11.023. Review.

4.

Impaired LRP6-TCF7L2 Activity Enhances Smooth Muscle Cell Plasticity and Causes Coronary Artery Disease.

Srivastava R, Zhang J, Go GW, Narayanan A, Nottoli TP, Mani A.

Cell Rep. 2015 Oct 27;13(4):746-759. doi: 10.1016/j.celrep.2015.09.028. Epub 2015 Oct 17.

5.

Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).

Palsgaard J, Emanuelli B, Winnay JN, Sumara G, Karsenty G, Kahn CR.

J Biol Chem. 2012 Apr 6;287(15):12016-26. doi: 10.1074/jbc.M111.337048. Epub 2012 Feb 15. Erratum in: J Biol Chem. 2016 Aug 5;291(32):16878.

6.

Rottlerin induces Wnt co-receptor LRP6 degradation and suppresses both Wnt/β-catenin and mTORC1 signaling in prostate and breast cancer cells.

Lu W, Lin C, Li Y.

Cell Signal. 2014 Jun;26(6):1303-9. doi: 10.1016/j.cellsig.2014.02.018. Epub 2014 Mar 6.

8.

Nonalcoholic fatty liver disease induced by noncanonical Wnt and its rescue by Wnt3a.

Wang S, Song K, Srivastava R, Dong C, Go GW, Li N, Iwakiri Y, Mani A.

FASEB J. 2015 Aug;29(8):3436-45. doi: 10.1096/fj.15-271171. Epub 2015 Apr 27.

9.

Adiponectin inhibits Wnt co-receptor, Lrp6, phosphorylation and β-catenin signaling.

Reinke L, Lam AP, Flozak AS, Varga J, Gottardi CJ.

Biochem Biophys Res Commun. 2016 Feb 12;470(3):606-612. doi: 10.1016/j.bbrc.2016.01.097. Epub 2016 Jan 23.

10.

Role of the Rap2/TNIK kinase pathway in regulation of LRP6 stability for Wnt signaling.

Park DS, Seo JH, Hong M, Choi SC.

Biochem Biophys Res Commun. 2013 Jun 28;436(2):338-43. doi: 10.1016/j.bbrc.2013.05.104. Epub 2013 Jun 4.

PMID:
23743195
11.

LRP6 exerts non-canonical effects on Wnt signaling during neural tube closure.

Gray JD, Kholmanskikh S, Castaldo BS, Hansler A, Chung H, Klotz B, Singh S, Brown AM, Ross ME.

Hum Mol Genet. 2013 Nov 1;22(21):4267-81. doi: 10.1093/hmg/ddt277. Epub 2013 Jun 16.

12.

The Wnt signaling pathway effector TCF7L2 is upregulated by insulin and represses hepatic gluconeogenesis.

Ip W, Shao W, Chiang YT, Jin T.

Am J Physiol Endocrinol Metab. 2012 Nov 1;303(9):E1166-76. doi: 10.1152/ajpendo.00249.2012. Epub 2012 Sep 11.

13.

Mature miR-183, negatively regulated by transcription factor GATA3, promotes 3T3-L1 adipogenesis through inhibition of the canonical Wnt/β-catenin signaling pathway by targeting LRP6.

Chen C, Xiang H, Peng YL, Peng J, Jiang SW.

Cell Signal. 2014 Jun;26(6):1155-65. doi: 10.1016/j.cellsig.2014.02.003. Epub 2014 Feb 18.

PMID:
24556500
14.

Association of a functional variant in the Wnt co-receptor LRP6 with early onset ileal Crohn's disease.

Koslowski MJ, Teltschik Z, Beisner J, Schaeffeler E, Wang G, Kübler I, Gersemann M, Cooney R, Jewell D, Reinisch W, Vermeire S, Rutgeerts P, Schwab M, Stange EF, Wehkamp J.

PLoS Genet. 2012;8(2):e1002523. doi: 10.1371/journal.pgen.1002523. Epub 2012 Feb 23.

15.

LRP6 mediates Wnt/β-catenin signaling and regulates adipogenic differentiation in human mesenchymal stem cells.

Peröbner I, Karow M, Jochum M, Neth P.

Int J Biochem Cell Biol. 2012 Nov;44(11):1970-82. doi: 10.1016/j.biocel.2012.07.025. Epub 2012 Aug 2.

PMID:
22871567
16.

The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis.

Shao W, Wang D, Chiang YT, Ip W, Zhu L, Xu F, Columbus J, Belsham DD, Irwin DM, Zhang H, Wen X, Wang Q, Jin T.

Diabetes. 2013 Mar;62(3):789-800. doi: 10.2337/db12-0365. Epub 2012 Sep 10.

17.

Insulin receptor isoform A confers a higher proliferative capability to pancreatic beta cells enabling glucose availability and IGF-I signaling.

Escribano O, Gómez-Hernández A, Díaz-Castroverde S, Nevado C, García G, Otero YF, Perdomo L, Beneit N, Benito M.

Mol Cell Endocrinol. 2015 Jul 5;409:82-91. doi: 10.1016/j.mce.2015.03.008. Epub 2015 Mar 19.

PMID:
25797178
18.

LRP6 protein regulates low density lipoprotein (LDL) receptor-mediated LDL uptake.

Ye ZJ, Go GW, Singh R, Liu W, Keramati AR, Mani A.

J Biol Chem. 2012 Jan 6;287(2):1335-44. doi: 10.1074/jbc.M111.295287. Epub 2011 Nov 28.

19.

IGF-1 receptor as an alternative receptor for metabolic signaling in insulin receptor-deficient muscle cells.

Baudry A, Lamothe B, Bucchini D, Jami J, Montarras D, Pinset C, Joshi RL.

FEBS Lett. 2001 Jan 19;488(3):174-8.

20.

Lypd6 enhances Wnt/β-catenin signaling by promoting Lrp6 phosphorylation in raft plasma membrane domains.

Özhan G, Sezgin E, Wehner D, Pfister AS, Kühl SJ, Kagermeier-Schenk B, Kühl M, Schwille P, Weidinger G.

Dev Cell. 2013 Aug 26;26(4):331-45. doi: 10.1016/j.devcel.2013.07.020.

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