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A powerful yeast model to investigate the synergistic interaction of α-synuclein and tau in neurodegeneration.

Ciaccioli G, Martins A, Rodrigues C, Vieira H, Calado P.

PLoS One. 2013;8(2):e55848. doi: 10.1371/journal.pone.0055848. Epub 2013 Feb 5.


Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.

Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF.

PLoS Genet. 2014 May 8;10(5):e1004302. doi: 10.1371/journal.pgen.1004302. eCollection 2014 May.


Wild type and P301L mutant Tau promote neuro-inflammation and α-Synuclein accumulation in lentiviral gene delivery models.

Khandelwal PJ, Dumanis SB, Herman AM, Rebeck GW, Moussa CE.

Mol Cell Neurosci. 2012 Jan;49(1):44-53. doi: 10.1016/j.mcn.2011.09.002. Epub 2011 Sep 14.


Interaction between α-synuclein and other proteins in neurodegenerative disorders.

Jellinger KA.

ScientificWorldJournal. 2011;11:1893-907. doi: 10.1100/2011/371893. Epub 2011 Oct 24. Review.


Alpha-synuclein and tau: teammates in neurodegeneration?

Moussaud S, Jones DR, Moussaud-Lamodière EL, Delenclos M, Ross OA, McLean PJ.

Mol Neurodegener. 2014 Oct 29;9:43. doi: 10.1186/1750-1326-9-43. Review.


Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation.

Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, Danzer KM, Outeiro TF.

PLoS Genet. 2014 Nov 13;10(11):e1004741. doi: 10.1371/journal.pgen.1004741. eCollection 2014 Nov.


Phosphorylation of tau and alpha-synuclein in synaptic-enriched fractions of the frontal cortex in Alzheimer's disease, and in Parkinson's disease and related alpha-synucleinopathies.

Muntané G, Dalfó E, Martinez A, Ferrer I.

Neuroscience. 2008 Apr 9;152(4):913-23. doi: 10.1016/j.neuroscience.2008.01.030. Epub 2008 Feb 5.


Abberant alpha-synuclein confers toxicity to neurons in part through inhibition of chaperone-mediated autophagy.

Xilouri M, Vogiatzi T, Vekrellis K, Park D, Stefanis L.

PLoS One. 2009;4(5):e5515. doi: 10.1371/journal.pone.0005515. Epub 2009 May 13.


Patterns of Tau and α-Synuclein Pathology in the Visual System.

Rahimi J, Milenkovic I, Kovacs GG.

J Parkinsons Dis. 2015;5(2):333-40. doi: 10.3233/JPD-140485.


shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity.

Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF.

PLoS Genet. 2016 Apr 28;12(4):e1005995. doi: 10.1371/journal.pgen.1005995. eCollection 2016 Apr. Erratum in: PLoS Genet. 2016 Jun;12(6):e1006148.


The small GTPase Rab11 co-localizes with α-synuclein in intracellular inclusions and modulates its aggregation, secretion and toxicity.

Chutna O, Gonçalves S, Villar-Piqué A, Guerreiro P, Marijanovic Z, Mendes T, Ramalho J, Emmanouilidou E, Ventura S, Klucken J, Barral DC, Giorgini F, Vekrellis K, Outeiro TF.

Hum Mol Genet. 2014 Dec 20;23(25):6732-45. doi: 10.1093/hmg/ddu391. Epub 2014 Aug 4.


DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease.

Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF.

Cell Death Dis. 2014 Jul 24;5:e1350. doi: 10.1038/cddis.2014.307.


Yeast reveals similar molecular mechanisms underlying alpha- and beta-synuclein toxicity.

Tenreiro S, Rosado-Ramos R, Gerhardt E, Favretto F, Magalhães F, Popova B, Becker S, Zweckstetter M, Braus GH, Outeiro TF.

Hum Mol Genet. 2016 Jan 15;25(2):275-90. doi: 10.1093/hmg/ddv470. Epub 2015 Nov 18.


Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline.

Clinton LK, Blurton-Jones M, Myczek K, Trojanowski JQ, LaFerla FM.

J Neurosci. 2010 May 26;30(21):7281-9. doi: 10.1523/JNEUROSCI.0490-10.2010.


Hyperphosphorylated Tau in an α-synuclein-overexpressing transgenic model of Parkinson's disease.

Haggerty T, Credle J, Rodriguez O, Wills J, Oaks AW, Masliah E, Sidhu A.

Eur J Neurosci. 2011 May;33(9):1598-610. doi: 10.1111/j.1460-9568.2011.07660.x. Epub 2011 Apr 1.


Distinct α-synuclein strains differentially promote tau inclusions in neurons.

Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM.

Cell. 2013 Jul 3;154(1):103-17. doi: 10.1016/j.cell.2013.05.057.


Interactions of amyloidogenic proteins.

Giasson BI, Lee VM, Trojanowski JQ.

Neuromolecular Med. 2003;4(1-2):49-58. Review.


Interactions Between α-Synuclein and Tau Protein: Implications to Neurodegenerative Disorders.

Li X, James S, Lei P.

J Mol Neurosci. 2016 Nov;60(3):298-304. Epub 2016 Sep 15. Review.


Parkin attenuates wild-type tau modification in the presence of beta-amyloid and alpha-synuclein.

Moussa CE.

J Mol Neurosci. 2009 Jan;37(1):25-36. doi: 10.1007/s12031-008-9099-x. Epub 2008 Jun 17. Erratum in: J Mol Neurosci. 2009 Mar;37(3):301.


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