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Items: 1 to 20 of 137

1.

Transcriptomic responses generated by hepatocarcinogens in a battery of liver-based in vitro models.

Doktorova TY, Yildirimman R, Vinken M, Vilardell M, Vanhaecke T, Gmuender H, Bort R, Brolen G, Holmgren G, Li R, Chesne C, van Delft J, Kleinjans J, Castell J, Bjorquist P, Herwig R, Rogiers V.

Carcinogenesis. 2013 Jun;34(6):1393-402. doi: 10.1093/carcin/bgt054. Epub 2013 Feb 7.

PMID:
23393228
2.

Comparison of hepatocarcinogen-induced gene expression profiles in conventional primary rat hepatocytes with in vivo rat liver.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V.

Arch Toxicol. 2012 Sep;86(9):1399-411. doi: 10.1007/s00204-012-0847-x. Epub 2012 Apr 8.

PMID:
22484513
3.

Comparison of HepG2 and HepaRG by whole-genome gene expression analysis for the purpose of chemical hazard identification.

Jennen DG, Magkoufopoulou C, Ketelslegers HB, van Herwijnen MH, Kleinjans JC, van Delft JH.

Toxicol Sci. 2010 May;115(1):66-79. doi: 10.1093/toxsci/kfq026. Epub 2010 Jan 27.

PMID:
20106945
4.

Discrimination for genotoxic and nongenotoxic carcinogens by gene expression profiling in primary mouse hepatocytes improves with exposure time.

Mathijs K, Brauers KJ, Jennen DG, Boorsma A, van Herwijnen MH, Gottschalk RW, Kleinjans JC, van Delft JH.

Toxicol Sci. 2009 Dec;112(2):374-84. doi: 10.1093/toxsci/kfp229. Epub 2009 Sep 21.

PMID:
19770486
5.

Discrimination of genotoxic from non-genotoxic carcinogens by gene expression profiling.

van Delft JH, van Agen E, van Breda SG, Herwijnen MH, Staal YC, Kleinjans JC.

Carcinogenesis. 2004 Jul;25(7):1265-76. Epub 2004 Feb 12. Erratum in: Carcinogenesis. 2004 Dec;25(12):2525. Carcinogenesis. 2005 Feb;26(2):511.

PMID:
14963013
6.

Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes.

Rieswijk L, Brauers KJ, Coonen ML, van Breda SG, Jennen DG, Kleinjans JC.

Mutagenesis. 2015 Nov;30(6):771-84. doi: 10.1093/mutage/gev036. Epub 2015 May 14.

PMID:
25976910
7.

Baseline and genotoxic compound induced gene expression profiles in HepG2 and HepaRG compared to primary human hepatocytes.

Jetten MJ, Kleinjans JC, Claessen SM, Chesné C, van Delft JH.

Toxicol In Vitro. 2013 Oct;27(7):2031-40. doi: 10.1016/j.tiv.2013.07.010. Epub 2013 Jul 31.

PMID:
23911569
9.

Benzo[a]pyrene-induced transcriptomic responses in primary hepatocytes and in vivo liver: toxicokinetics is essential for in vivo-in vitro comparisons.

van Kesteren PC, Zwart PE, Schaap MM, Pronk TE, van Herwijnen MH, Kleinjans JC, Bokkers BG, Godschalk RW, Zeilmaker MJ, van Steeg H, Luijten M.

Arch Toxicol. 2013 Mar;87(3):505-15. doi: 10.1007/s00204-012-0949-5. Epub 2012 Oct 2.

PMID:
23052197
10.

Comparison of the expression profiles induced by genotoxic and nongenotoxic carcinogens in rat liver.

Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ.

Mutat Res. 2005 Aug 4;575(1-2):61-84.

PMID:
15890375
11.

Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks.

Rieswijk L, Lizarraga D, Brauers KJ, Kleinjans JC, van Delft JH.

Mutagenesis. 2014 Jan;29(1):17-26. doi: 10.1093/mutage/get055. Epub 2013 Nov 26.

PMID:
24280081
12.

Comparison of genotoxicant-modified transcriptomic responses in conventional and epigenetically stabilized primary rat hepatocytes with in vivo rat liver data.

Doktorova TY, Ellinger-Ziegelbauer H, Vinken M, Vanhaecke T, van Delft J, Kleinjans J, Ahr HJ, Rogiers V.

Arch Toxicol. 2012 Nov;86(11):1703-15. doi: 10.1007/s00204-012-0946-8. Epub 2012 Sep 28.

PMID:
23052194
13.

Human embryonic stem cell derived hepatocyte-like cells as a tool for in vitro hazard assessment of chemical carcinogenicity.

Yildirimman R, Brolén G, Vilardell M, Eriksson G, Synnergren J, Gmuender H, Kamburov A, Ingelman-Sundberg M, Castell J, Lahoz A, Kleinjans J, van Delft J, Björquist P, Herwig R.

Toxicol Sci. 2011 Dec;124(2):278-90. doi: 10.1093/toxsci/kfr225. Epub 2011 Aug 27.

14.

Oxidative Stress Mechanisms Do Not Discriminate between Genotoxic and Nongenotoxic Liver Carcinogens.

Deferme L, Wolters J, Claessen S, Briedé J, Kleinjans J.

Chem Res Toxicol. 2015 Aug 17;28(8):1636-46. doi: 10.1021/acs.chemrestox.5b00222. Epub 2015 Aug 4.

PMID:
26198647
15.

Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity.

Rieswijk L, Brauers KJ, Coonen ML, Jennen DG, van Breda SG, Kleinjans JC.

Mutagenesis. 2016 Sep;31(5):603-15. doi: 10.1093/mutage/gew027. Epub 2016 Jun 23.

PMID:
27338304
16.

Identification of early target genes of aflatoxin B1 in human hepatocytes, inter-individual variability and comparison with other genotoxic compounds.

Josse R, Dumont J, Fautrel A, Robin MA, Guillouzo A.

Toxicol Appl Pharmacol. 2012 Jan 15;258(2):176-87. doi: 10.1016/j.taap.2011.10.019. Epub 2011 Nov 4.

PMID:
22100608
17.

Dissecting modes of action of non-genotoxic carcinogens in primary mouse hepatocytes.

Schaap MM, Zwart EP, Wackers PF, Huijskens I, van de Water B, Breit TM, van Steeg H, Jonker MJ, Luijten M.

Arch Toxicol. 2012 Nov;86(11):1717-27. doi: 10.1007/s00204-012-0883-6. Epub 2012 Jun 19.

PMID:
22710402
18.

Differential gene expression profiling between genotoxic and non-genotoxic hepatocarcinogens in young rat liver determined by quantitative real-time PCR and principal component analysis.

Suenaga K, Takasawa H, Watanabe T, Wako Y, Suzuki T, Hamada S, Furihata C.

Mutat Res. 2013 Feb 18;751(1):73-83. doi: 10.1016/j.mrgentox.2012.11.003. Epub 2012 Nov 24.

PMID:
23183053
19.

A novel toxicogenomics-based approach to categorize (non-)genotoxic carcinogens.

Schaap MM, Wackers PF, Zwart EP, Huijskens I, Jonker MJ, Hendriks G, Breit TM, van Steeg H, van de Water B, Luijten M.

Arch Toxicol. 2015 Dec;89(12):2413-27. doi: 10.1007/s00204-014-1368-6. Epub 2014 Oct 2.

PMID:
25270620
20.

Characteristic expression profiles induced by genotoxic carcinogens in rat liver.

Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W, Ahr HJ.

Toxicol Sci. 2004 Jan;77(1):19-34. Epub 2003 Nov 4.

PMID:
14600272

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