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Constitutive CCND1/CDK2 activity substitutes for p53 loss, or MYC or oncogenic RAS expression in the transformation of human mammary epithelial cells.

Junk DJ, Cipriano R, Stampfer M, Jackson MW.

PLoS One. 2013;8(2):e53776. doi: 10.1371/journal.pone.0053776. Epub 2013 Feb 4.


Humanization of the mouse mammary gland by replacement of the luminal layer with genetically engineered preneoplastic human cells.

Verbeke S, Richard E, Monceau E, Schmidt X, Rousseau B, Velasco V, Bernard D, Bonnefoi H, MacGrogan G, Iggo RD.

Breast Cancer Res. 2014 Dec 20;16(6):504. doi: 10.1186/s13058-014-0504-9. Erratum in: Breast Cancer Res. 2015;17(1):126.


Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation.

Hydbring P, Bahram F, Su Y, Tronnersjö S, Högstrand K, von der Lehr N, Sharifi HR, Lilischkis R, Hein N, Wu S, Vervoorts J, Henriksson M, Grandien A, Lüscher B, Larsson LG.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):58-63. doi: 10.1073/pnas.0900121106. Epub 2009 Dec 4.


Myc, Cdk2 and cellular senescence: Old players, new game.

Campaner S, Doni M, Verrecchia A, Fagà G, Bianchi L, Amati B.

Cell Cycle. 2010 Sep 15;9(18):3655-61. Epub 2010 Sep 15.


Oncogenic transformation of human ovarian surface epithelial cells with defined cellular oncogenes.

Sasaki R, Narisawa-Saito M, Yugawa T, Fujita M, Tashiro H, Katabuchi H, Kiyono T.

Carcinogenesis. 2009 Mar;30(3):423-31. doi: 10.1093/carcin/bgp007. Epub 2009 Jan 6.


Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells.

Kang J, Sergio CM, Sutherland RL, Musgrove EA.

BMC Cancer. 2014 Jan 20;14:32. doi: 10.1186/1471-2407-14-32.


Isogenic human mammary epithelial cell lines: novel tools for target identification and validation. Comprehensive characterization of an isogenic human mammary epithelial cell model provides evidence for epithelial-mesenchymal transition.

Ulbricht U, Sommer A, Beckmann G, Lutzenberger M, Seidel H, Kreft B, Toschi L.

Breast Cancer Res Treat. 2013 Apr;138(2):437-56. doi: 10.1007/s10549-013-2472-7. Epub 2013 Mar 13.


Tipping the balance: Cdk2 enables Myc to suppress senescence.

Hydbring P, Larsson LG.

Cancer Res. 2010 Sep 1;70(17):6687-91. doi: 10.1158/0008-5472.CAN-10-1383. Epub 2010 Aug 16. Review.


PIN1 is an E2F target gene essential for Neu/Ras-induced transformation of mammary epithelial cells.

Ryo A, Liou YC, Wulf G, Nakamura M, Lee SW, Lu KP.

Mol Cell Biol. 2002 Aug;22(15):5281-95.


TGF-beta signaling engages an ATM-CHK2-p53-independent RAS-induced senescence and prevents malignant transformation in human mammary epithelial cells.

Cipriano R, Kan CE, Graham J, Danielpour D, Stampfer M, Jackson MW.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8668-73. doi: 10.1073/pnas.1015022108. Epub 2011 May 9.


A network of genetic events sufficient to convert normal human cells to a tumorigenic state.

Kendall SD, Linardic CM, Adam SJ, Counter CM.

Cancer Res. 2005 Nov 1;65(21):9824-8.


Estrogen regulation of cyclin E2 requires cyclin D1 but not c-Myc.

Caldon CE, Sergio CM, Schütte J, Boersma MN, Sutherland RL, Carroll JS, Musgrove EA.

Mol Cell Biol. 2009 Sep;29(17):4623-39. doi: 10.1128/MCB.00269-09. Epub 2009 Jun 29.


A human cancer xenograft model utilizing normal pancreatic duct epithelial cells conditionally transformed with defined oncogenes.

Inagawa Y, Yamada K, Yugawa T, Ohno S, Hiraoka N, Esaki M, Shibata T, Aoki K, Saya H, Kiyono T.

Carcinogenesis. 2014 Aug;35(8):1840-6. doi: 10.1093/carcin/bgu112. Epub 2014 May 24.


Synergistic effect of Bcl2, Myc and Ccnd1 transforms mouse primary B cells into malignant cells.

Nakagawa M, Tsuzuki S, Honma K, Taguchi O, Seto M.

Haematologica. 2011 Sep;96(9):1318-26. doi: 10.3324/haematol.2011.041053. Epub 2011 May 23.


Investigation of the cell cycle regulation of cdk3-associated kinase activity and the role of cdk3 in proliferation and transformation.

Braun K, Hölzl G, Soucek T, Geisen C, Möröy T, Hengstschläger M.

Oncogene. 1998 Oct 29;17(17):2259-69.


Construction of a cyclin D1-Cdk2 fusion protein to model the biological functions of cyclin D1-Cdk2 complexes.

Chytil A, Waltner-Law M, West R, Friedman D, Aakre M, Barker D, Law B.

J Biol Chem. 2004 Nov 12;279(46):47688-98. Epub 2004 Sep 7.


Tissue array for Tp53, C-myc, CCND1 gene over-expression in different tumors.

Liu GY, Luo Q, Xiong B, Pan C, Yin P, Liao HF, Zhuang WC, Gao HZ.

World J Gastroenterol. 2008 Dec 21;14(47):7199-207.

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