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Biphasic Erk1/2 activation sequentially involving Gs and Gi signaling is required in beta3-adrenergic receptor-induced primary smooth muscle cell proliferation.

Hadi T, Barrichon M, Mourtialon P, Wendremaire M, Garrido C, Sagot P, Bardou M, Lirussi F.

Biochim Biophys Acta. 2013 May;1833(5):1041-51. doi: 10.1016/j.bbamcr.2013.01.019. Epub 2013 Feb 4.


Protein kinase A-mediated phosphorylation of the beta 2-adrenergic receptor regulates its coupling to Gs and Gi. Demonstration in a reconstituted system.

Zamah AM, Delahunty M, Luttrell LM, Lefkowitz RJ.

J Biol Chem. 2002 Aug 23;277(34):31249-56. Epub 2002 Jun 12.


The beta3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism.

Soeder KJ, Snedden SK, Cao W, Della Rocca GJ, Daniel KW, Luttrell LM, Collins S.

J Biol Chem. 1999 Apr 23;274(17):12017-22.


Contribution of the extracellular cAMP-adenosine pathway to dual coupling of β2-adrenoceptors to Gs and Gi proteins in mouse skeletal muscle.

Duarte T, Menezes-Rodrigues FS, Godinho RO.

J Pharmacol Exp Ther. 2012 Jun;341(3):820-8. doi: 10.1124/jpet.112.192997. Epub 2012 Mar 21.


Both Gs and Gi proteins are critically involved in isoproterenol-induced cardiomyocyte hypertrophy.

Zou Y, Komuro I, Yamazaki T, Kudoh S, Uozumi H, Kadowaki T, Yazaki Y.

J Biol Chem. 1999 Apr 2;274(14):9760-70.


Insulin-like growth factor-binding protein-5 stimulates growth of human intestinal muscle cells by activation of G{alpha}i3.

Flynn RS, Mahavadi S, Murthy KS, Kellum JM, Kuemmerle JF.

Am J Physiol Gastrointest Liver Physiol. 2009 Dec;297(6):G1232-8. doi: 10.1152/ajpgi.00323.2009. Epub 2009 Oct 1.


Isoproterenol induces actin depolymerization in human airway smooth muscle cells via activation of an Src kinase and GS.

Hirshman CA, Zhu D, Pertel T, Panettieri RA, Emala CW.

Am J Physiol Lung Cell Mol Physiol. 2005 May;288(5):L924-31.


Phosphatidylinositol 3-kinase offsets cAMP-mediated positive inotropic effect via inhibiting Ca2+ influx in cardiomyocytes.

Leblais V, Jo SH, Chakir K, Maltsev V, Zheng M, Crow MT, Wang W, Lakatta EG, Xiao RP.

Circ Res. 2004 Dec 10;95(12):1183-90. Epub 2004 Nov 11.


Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.

Gosmanov AR, Wong JA, Thomason DB.

Am J Physiol Cell Physiol. 2002 Oct;283(4):C1025-32.


The role of beta-adrenergic receptor signaling in cardioprotection.

Tong H, Bernstein D, Murphy E, Steenbergen C.

FASEB J. 2005 Jun;19(8):983-5. Epub 2005 Mar 31.


Switching of the coupling of the beta2-adrenergic receptor to different G proteins by protein kinase A.

Daaka Y, Luttrell LM, Lefkowitz RJ.

Nature. 1997 Nov 6;390(6655):88-91.

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