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Items: 1 to 20 of 75

1.

mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.

Dai N, Christiansen J, Nielsen FC, Avruch J.

Genes Dev. 2013 Feb 1;27(3):301-12. doi: 10.1101/gad.209130.112.

2.

mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry.

Dai N, Rapley J, Angel M, Yanik MF, Blower MD, Avruch J.

Genes Dev. 2011 Jun 1;25(11):1159-72. doi: 10.1101/gad.2042311. Epub 2011 May 16.

3.

Expression of mouse igf2 mRNA-binding protein 3 and its implications for the developing central nervous system.

Mori H, Sakakibara S, Imai T, Nakamura Y, Iijima T, Suzuki A, Yuasa Y, Takeda M, Okano H.

J Neurosci Res. 2001 Apr 15;64(2):132-43.

PMID:
11288142
4.

mTORC2 can associate with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide.

Oh WJ, Wu CC, Kim SJ, Facchinetti V, Julien LA, Finlan M, Roux PP, Su B, Jacinto E.

EMBO J. 2010 Dec 1;29(23):3939-51. doi: 10.1038/emboj.2010.271. Epub 2010 Nov 2.

5.

CRD-BP/IMP1 expression characterizes cord blood CD34+ stem cells and affects c-myc and IGF-II expression in MCF-7 cancer cells.

Ioannidis P, Mahaira LG, Perez SA, Gritzapis AD, Sotiropoulou PA, Kavalakis GJ, Antsaklis AI, Baxevanis CN, Papamichail M.

J Biol Chem. 2005 May 20;280(20):20086-93. Epub 2005 Mar 14.

6.

Role of p70S6K1-mediated phosphorylation of eIF4B and PDCD4 proteins in the regulation of protein synthesis.

Dennis MD, Jefferson LS, Kimball SR.

J Biol Chem. 2012 Dec 14;287(51):42890-9. doi: 10.1074/jbc.M112.404822. Epub 2012 Oct 26.

7.
8.

A unifying model for mTORC1-mediated regulation of mRNA translation.

Thoreen CC, Chantranupong L, Keys HR, Wang T, Gray NS, Sabatini DM.

Nature. 2012 May 2;485(7396):109-13. doi: 10.1038/nature11083.

9.

Dwarfism and impaired gut development in insulin-like growth factor II mRNA-binding protein 1-deficient mice.

Hansen TV, Hammer NA, Nielsen J, Madsen M, Dalbaeck C, Wewer UM, Christiansen J, Nielsen FC.

Mol Cell Biol. 2004 May;24(10):4448-64.

10.

Expression of IGF-II mRNA-binding proteins (IMPs) in gonads and testicular cancer.

Hammer NA, Hansen Tv, Byskov AG, Rajpert-De Meyts E, Gr√łndahl ML, Bredkjaer HE, Wewer UM, Christiansen J, Nielsen FC.

Reproduction. 2005 Aug;130(2):203-12.

11.

Targeted knockdown of the RNA-binding protein CRD-BP promotes cell proliferation via an insulin-like growth factor II-dependent pathway in human K562 leukemia cells.

Liao B, Patel M, Hu Y, Charles S, Herrick DJ, Brewer G.

J Biol Chem. 2004 Nov 19;279(47):48716-24. Epub 2004 Sep 8.

12.

RELB Alters Proliferation of Human Pluripotent Stem Cells via IMP3- and LIN28-Mediated Modulation of the Expression of IGF2 and Other Cell-Cycle Regulators.

Thakar NY, Ovchinnikov DA, Hastie ML, Gorman J, Wolvetang EJ.

Stem Cells Dev. 2015 Aug 15;24(16):1888-900. doi: 10.1089/scd.2014.0587. Epub 2015 May 5.

PMID:
25794352
13.

IKK interacts with rictor and regulates mTORC2.

Xu Y, Lai E, Liu J, Lin J, Yang C, Jia C, Li Y, Bai X, Li M.

Cell Signal. 2013 Nov;25(11):2239-45. doi: 10.1016/j.cellsig.2013.07.008. Epub 2013 Jul 17.

PMID:
23872070
14.

The IGF2 intronic miR-483 selectively enhances transcription from IGF2 fetal promoters and enhances tumorigenesis.

Liu M, Roth A, Yu M, Morris R, Bersani F, Rivera MN, Lu J, Shioda T, Vasudevan S, Ramaswamy S, Maheswaran S, Diederichs S, Haber DA.

Genes Dev. 2013 Dec 1;27(23):2543-8. doi: 10.1101/gad.224170.113.

15.

mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice.

Chen X, Wang Y, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H.

Gastroenterology. 2015 Sep;149(3):741-52.e14. doi: 10.1053/j.gastro.2015.05.005. Epub 2015 May 14.

PMID:
25980751
16.

PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.

Woo SY, Kim DH, Jun CB, Kim YM, Haar EV, Lee SI, Hegg JW, Bandhakavi S, Griffin TJ, Kim DH.

J Biol Chem. 2007 Aug 31;282(35):25604-12. Epub 2007 Jun 28.

17.

Constitutive phosphorylation of the mTORC2/Akt/4E-BP1 pathway in newly derived canine hemangiosarcoma cell lines.

Murai A, Asa SA, Kodama A, Hirata A, Yanai T, Sakai H.

BMC Vet Res. 2012 Jul 29;8:128. doi: 10.1186/1746-6148-8-128.

18.

IMP1 promotes choriocarcinoma cell migration and invasion through the novel effectors RSK2 and PPME1.

Hsieh YT, Chou MM, Chen HC, Tseng JJ.

Gynecol Oncol. 2013 Oct;131(1):182-90. doi: 10.1016/j.ygyno.2013.07.106. Epub 2013 Aug 1.

PMID:
23911878
19.

High prevalence of mTOR complex activity can be targeted using Torin2 in papillary thyroid carcinoma.

Ahmed M, Hussain AR, Bavi P, Ahmed SO, Al Sobhi SS, Al-Dayel F, Uddin S, Al-Kuraya KS.

Carcinogenesis. 2014 Jul;35(7):1564-72. doi: 10.1093/carcin/bgu051. Epub 2014 Feb 28.

PMID:
24583924

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