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Items: 1 to 20 of 126


3C protease of enterovirus 68: structure-based design of Michael acceptor inhibitors and their broad-spectrum antiviral effects against picornaviruses.

Tan J, George S, Kusov Y, Perbandt M, Anemüller S, Mesters JR, Norder H, Coutard B, Lacroix C, Leyssen P, Neyts J, Hilgenfeld R.

J Virol. 2013 Apr;87(8):4339-51. doi: 10.1128/JVI.01123-12. Epub 2013 Feb 6.


Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses.

Kim Y, Lovell S, Tiew KC, Mandadapu SR, Alliston KR, Battaile KP, Groutas WC, Chang KO.

J Virol. 2012 Nov;86(21):11754-62. doi: 10.1128/JVI.01348-12. Epub 2012 Aug 22.


Design, synthesis, and evaluation of 3C protease inhibitors as anti-enterovirus 71 agents.

Kuo CJ, Shie JJ, Fang JM, Yen GR, Hsu JT, Liu HG, Tseng SN, Chang SC, Lee CY, Shih SR, Liang PH.

Bioorg Med Chem. 2008 Aug 1;16(15):7388-98. doi: 10.1016/j.bmc.2008.06.015. Epub 2008 Jun 13.


Identification and biochemical characterization of DC07090 as a novel potent small molecule inhibitor against human enterovirus 71 3C protease by structure-based virtual screening.

Ma GH, Ye Y, Zhang D, Xu X, Si P, Peng JL, Xiao YL, Cao RY, Yin YL, Chen J, Zhao LX, Zhou Y, Zhong W, Liu H, Luo XM, Chen LL, Shen X.

Eur J Med Chem. 2016 Nov 29;124:981-991. doi: 10.1016/j.ejmech.2016.10.019. Epub 2016 Oct 11.


Picornaviral 3C protease inhibitors and the dual 3C protease/coronaviral 3C-like protease inhibitors.

Wang HM, Liang PH.

Expert Opin Ther Pat. 2010 Jan;20(1):59-71. doi: 10.1517/13543770903460323. Review.


Structural basis for antiviral inhibition of the main protease, 3C, from human enterovirus 93.

Costenaro L, Kaczmarska Z, Arnan C, Janowski R, Coutard B, Solà M, Gorbalenya AE, Norder H, Canard B, Coll M.

J Virol. 2011 Oct;85(20):10764-73. doi: 10.1128/JVI.05062-11. Epub 2011 Aug 10.


Application of a cell-based protease assay for testing inhibitors of picornavirus 3C proteases.

van der Linden L, Ulferts R, Nabuurs SB, Kusov Y, Liu H, George S, Lacroix C, Goris N, Lefebvre D, Lanke KH, De Clercq K, Hilgenfeld R, Neyts J, van Kuppeveld FJ.

Antiviral Res. 2014 Mar;103:17-24. doi: 10.1016/j.antiviral.2013.12.012. Epub 2014 Jan 4.


Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.

Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST.

Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7.


Enterovirus 71 and coxsackievirus A16 3C proteases: binding to rupintrivir and their substrates and anti-hand, foot, and mouth disease virus drug design.

Lu G, Qi J, Chen Z, Xu X, Gao F, Lin D, Qian W, Liu H, Jiang H, Yan J, Gao GF.

J Virol. 2011 Oct;85(19):10319-31. doi: 10.1128/JVI.00787-11. Epub 2011 Jul 27.


Design and synthesis of irreversible depsipeptidyl human rhinovirus 3C protease inhibitors.

Webber SE, Marakovits JT, Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Srinivasan B, Moran T, Ford CE, Brothers MA, Harr JE, Meador JW 3rd, Ferre RA, Worland ST.

Bioorg Med Chem Lett. 2001 Oct 22;11(20):2683-6.


Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir.

Wu C, Cai Q, Chen C, Li N, Peng X, Cai Y, Yin K, Chen X, Wang X, Zhang R, Liu L, Chen S, Li J, Lin T.

Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):866-71. doi: 10.1107/S0907444913002862. Epub 2013 Apr 19.


Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay.

Shang L, Zhang S, Yang X, Sun J, Li L, Cui Z, He Q, Guo Y, Sun Y, Yin Z.

Antimicrob Agents Chemother. 2015 Apr;59(4):1827-36. doi: 10.1128/AAC.04698-14. Epub 2014 Nov 24.


Synthesis and structure-activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors.

Zeng D, Ma Y, Zhang R, Nie Q, Cui Z, Wang Y, Shang L, Yin Z.

Bioorg Med Chem Lett. 2016 Apr 1;26(7):1762-6. doi: 10.1016/j.bmcl.2016.02.039. Epub 2016 Feb 16.


Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

Binford SL, Maldonado F, Brothers MA, Weady PT, Zalman LS, Meador JW 3rd, Matthews DA, Patick AK.

Antimicrob Agents Chemother. 2005 Feb;49(2):619-26.


Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.

Dragovich PS, Prins TJ, Zhou R, Brown EL, Maldonado FC, Fuhrman SA, Zalman LS, Tuntland T, Lee CA, Patick AK, Matthews DA, Hendrickson TF, Kosa MB, Liu B, Batugo MR, Gleeson JP, Sakata SK, Chen L, Guzman MC, Meador JW 3rd, Ferre RA, Worland ST.

J Med Chem. 2002 Apr 11;45(8):1607-23.


Crystal structure of human enterovirus 71 3C protease.

Cui S, Wang J, Fan T, Qin B, Guo L, Lei X, Wang J, Wang M, Jin Q.

J Mol Biol. 2011 May 6;408(3):449-61. doi: 10.1016/j.jmb.2011.03.007. Epub 2011 Mar 17.


Cyanohydrin as an Anchoring Group for Potent and Selective Inhibitors of Enterovirus 71 3C Protease.

Zhai Y, Zhao X, Cui Z, Wang M, Wang Y, Li L, Sun Q, Yang X, Zeng D, Liu Y, Sun Y, Lou Z, Shang L, Yin Z.

J Med Chem. 2015 Dec 10;58(23):9414-20. doi: 10.1021/acs.jmedchem.5b01013. Epub 2015 Nov 25.


Insights into cleavage specificity from the crystal structure of foot-and-mouth disease virus 3C protease complexed with a peptide substrate.

Zunszain PA, Knox SR, Sweeney TR, Yang J, Roqué-Rosell N, Belsham GJ, Leatherbarrow RJ, Curry S.

J Mol Biol. 2010 Jan 15;395(2):375-89. doi: 10.1016/j.jmb.2009.10.048. Epub 2009 Oct 31.


Structure-based design of a parallel synthetic array directed toward the discovery of irreversible inhibitors of human rhinovirus 3C protease.

Johnson TO, Hua Y, Luu HT, Brown EL, Chan F, Chu SS, Dragovich PS, Eastman BW, Ferre RA, Fuhrman SA, Hendrickson TF, Maldonado FC, Matthews DA, Meador JW 3rd, Patick AK, Reich SH, Skalitzky DJ, Worland ST, Yang M, Zalman LS.

J Med Chem. 2002 May 9;45(10):2016-23.


In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.

Patick AK, Binford SL, Brothers MA, Jackson RL, Ford CE, Diem MD, Maldonado F, Dragovich PS, Zhou R, Prins TJ, Fuhrman SA, Meador JW, Zalman LS, Matthews DA, Worland ST.

Antimicrob Agents Chemother. 1999 Oct;43(10):2444-50.

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