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Items: 1 to 20 of 122

1.

Prion protein-mediated toxicity of amyloid-β oligomers requires lipid rafts and the transmembrane LRP1.

Rushworth JV, Griffiths HH, Watt NT, Hooper NM.

J Biol Chem. 2013 Mar 29;288(13):8935-51. doi: 10.1074/jbc.M112.400358.

2.

Amyloid-β-induced synapse damage is mediated via cross-linkage of cellular prion proteins.

Bate C, Williams A.

J Biol Chem. 2011 Nov 4;286(44):37955-63. doi: 10.1074/jbc.M111.248724.

3.

Membrane-bound beta-amyloid oligomers are recruited into lipid rafts by a fyn-dependent mechanism.

Williamson R, Usardi A, Hanger DP, Anderton BH.

FASEB J. 2008 May;22(5):1552-9.

4.

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Laurén J, Gimbel DA, Nygaard HB, Gilbert JW, Strittmatter SM.

Nature. 2009 Feb 26;457(7233):1128-32. doi: 10.1038/nature07761.

5.

Alzheimer's amyloid-β oligomers rescue cellular prion protein induced tau reduction via the Fyn pathway.

Chen RJ, Chang WW, Lin YC, Cheng PL, Chen YR.

ACS Chem Neurosci. 2013 Sep 18;4(9):1287-96. doi: 10.1021/cn400085q.

6.

Exosomal cellular prion protein drives fibrillization of amyloid beta and counteracts amyloid beta-mediated neurotoxicity.

Falker C, Hartmann A, Guett I, Dohler F, Altmeppen H, Betzel C, Schubert R, Thurm D, Wegwitz F, Joshi P, Verderio C, Krasemann S, Glatzel M.

J Neurochem. 2016 Apr;137(1):88-100. doi: 10.1111/jnc.13514.

PMID:
26710111
7.

Soluble Prion Protein Binds Isolated Low Molecular Weight Amyloid-β Oligomers Causing Cytotoxicity Inhibition.

Williams TL, Choi JK, Surewicz K, Surewicz WK.

ACS Chem Neurosci. 2015 Dec 16;6(12):1972-80. doi: 10.1021/acschemneuro.5b00229.

PMID:
26466138
8.

Cellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.

Parkin ET, Watt NT, Hussain I, Eckman EA, Eckman CB, Manson JC, Baybutt HN, Turner AJ, Hooper NM.

Proc Natl Acad Sci U S A. 2007 Jun 26;104(26):11062-7.

9.

Amyloid-beta oligomers increase the localization of prion protein at the cell surface.

Caetano FA, Beraldo FH, Hajj GN, Guimaraes AL, Jürgensen S, Wasilewska-Sampaio AP, Hirata PH, Souza I, Machado CF, Wong DY, De Felice FG, Ferreira ST, Prado VF, Rylett RJ, Martins VR, Prado MA.

J Neurochem. 2011 May;117(3):538-53. doi: 10.1111/j.1471-4159.2011.07225.x.

10.

An N-terminal fragment of the prion protein binds to amyloid-β oligomers and inhibits their neurotoxicity in vivo.

Fluharty BR, Biasini E, Stravalaci M, Sclip A, Diomede L, Balducci C, La Vitola P, Messa M, Colombo L, Forloni G, Borsello T, Gobbi M, Harris DA.

J Biol Chem. 2013 Mar 15;288(11):7857-66. doi: 10.1074/jbc.M112.423954.

11.

Amyloid-β induced signaling by cellular prion protein and Fyn kinase in Alzheimer disease.

Um JW, Strittmatter SM.

Prion. 2013 Jan-Feb;7(1):37-41. doi: 10.4161/pri.22212. Review.

12.

Metabotropic glutamate receptor 5 is a coreceptor for Alzheimer aβ oligomer bound to cellular prion protein.

Um JW, Kaufman AC, Kostylev M, Heiss JK, Stagi M, Takahashi H, Kerrisk ME, Vortmeyer A, Wisniewski T, Koleske AJ, Gunther EC, Nygaard HB, Strittmatter SM.

Neuron. 2013 Sep 4;79(5):887-902. doi: 10.1016/j.neuron.2013.06.036. Erratum in: Neuron. 2013 Oct 16;80(2):531.

13.

Synthetic amyloid-beta oligomers impair long-term memory independently of cellular prion protein.

Balducci C, Beeg M, Stravalaci M, Bastone A, Sclip A, Biasini E, Tapella L, Colombo L, Manzoni C, Borsello T, Chiesa R, Gobbi M, Salmona M, Forloni G.

Proc Natl Acad Sci U S A. 2010 Feb 2;107(5):2295-300. doi: 10.1073/pnas.0911829107.

14.

Mitogen-activated protein kinase signaling pathways promote low-density lipoprotein receptor-related protein 1-mediated internalization of beta-amyloid protein in primary cortical neurons.

Yang WN, Ma KG, Qian YH, Zhang JS, Feng GF, Shi LL, Zhang ZC, Liu ZH.

Int J Biochem Cell Biol. 2015 Jul;64:252-64. doi: 10.1016/j.biocel.2015.04.013.

PMID:
25936756
15.

Soluble prion protein inhibits amyloid-β (Aβ) fibrillization and toxicity.

Nieznanski K, Choi JK, Chen S, Surewicz K, Surewicz WK.

J Biol Chem. 2012 Sep 28;287(40):33104-8.

16.

Activation of zebrafish Src family kinases by the prion protein is an amyloid-β-sensitive signal that prevents the endocytosis and degradation of E-cadherin/β-catenin complexes in vivo.

Sempou E, Biasini E, Pinzón-Olejua A, Harris DA, Málaga-Trillo E.

Mol Neurodegener. 2016 Feb 9;11:18. doi: 10.1186/s13024-016-0076-5.

17.

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons.

Um JW, Nygaard HB, Heiss JK, Kostylev MA, Stagi M, Vortmeyer A, Wisniewski T, Gunther EC, Strittmatter SM.

Nat Neurosci. 2012 Sep;15(9):1227-35. doi: 10.1038/nn.3178.

18.

Assemblages of prion fragments: novel model systems for understanding amyloid toxicity.

Satheeshkumar KS, Murali J, Jayakumar R.

J Struct Biol. 2004 Nov;148(2):176-93.

PMID:
15477098
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