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A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency.

Liang Y, Quenelle D, Vogel JL, Mascaro C, Ortega A, Kristie TM.

MBio. 2013 Feb 5;4(1):e00558-12. doi: 10.1128/mBio.00558-12.


Inhibition of the histone demethylase LSD1 blocks alpha-herpesvirus lytic replication and reactivation from latency.

Liang Y, Vogel JL, Narayanan A, Peng H, Kristie TM.

Nat Med. 2009 Nov;15(11):1312-7. doi: 10.1038/nm.2051. Epub 2009 Oct 25.


Targeting the JMJD2 histone demethylases to epigenetically control herpesvirus infection and reactivation from latency.

Liang Y, Vogel JL, Arbuckle JH, Rai G, Jadhav A, Simeonov A, Maloney DJ, Kristie TM.

Sci Transl Med. 2013 Jan 9;5(167):167ra5. doi: 10.1126/scitranslmed.3005145.


Inhibition of LSD1 reduces herpesvirus infection, shedding, and recurrence by promoting epigenetic suppression of viral genomes.

Hill JM, Quenelle DC, Cardin RD, Vogel JL, Clement C, Bravo FJ, Foster TP, Bosch-Marce M, Raja P, Lee JS, Bernstein DI, Krause PR, Knipe DM, Kristie TM.

Sci Transl Med. 2014 Dec 3;6(265):265ra169. doi: 10.1126/scitranslmed.3010643.


A targeted RNA interference screen reveals novel epigenetic factors that regulate herpesviral gene expression.

Oh HS, Bryant KF, Nieland TJ, Mazumder A, Bagul M, Bathe M, Root DE, Knipe DM.

MBio. 2014 Feb 4;5(1):e01086-13. doi: 10.1128/mBio.01086-13.


Dynamic modulation of HSV chromatin drives initiation of infection and provides targets for epigenetic therapies.

Kristie TM.

Virology. 2015 May;479-480:555-61. doi: 10.1016/j.virol.2015.01.026. Epub 2015 Feb 18. Review.


Epigenetic repression of herpes simplex virus infection by the nucleosome remodeler CHD3.

Arbuckle JH, Kristie TM.

MBio. 2014 Jan 14;5(1):e01027-13. doi: 10.1128/mBio.01027-13.


Inhibitors of the Histone Methyltransferases EZH2/1 Induce a Potent Antiviral State and Suppress Infection by Diverse Viral Pathogens.

Arbuckle JH, Gardina PJ, Gordon DN, Hickman HD, Yewdell JW, Pierson TC, Myers TG, Kristie TM.

MBio. 2017 Aug 15;8(4). pii: e01141-17. doi: 10.1128/mBio.01141-17.


Inhibition of O-Linked N-Acetylglucosamine Transferase Reduces Replication of Herpes Simplex Virus and Human Cytomegalovirus.

Angelova M, Ortiz-Meoz RF, Walker S, Knipe DM.

J Virol. 2015 Aug;89(16):8474-83. doi: 10.1128/JVI.01002-15. Epub 2015 Jun 3.


Restarting Lytic Gene Transcription at the Onset of Herpes Simplex Virus Reactivation.

Cliffe AR, Wilson AC.

J Virol. 2017 Jan 3;91(2). pii: e01419-16. doi: 10.1128/JVI.01419-16. Print 2017 Jan 15. Review.


Epigenetically repressing human cytomegalovirus lytic infection and reactivation from latency in THP-1 model by targeting H3K9 and H3K27 histone demethylases.

Gan X, Wang H, Yu Y, Yi W, Zhu S, Li E, Liang Y.

PLoS One. 2017 Apr 13;12(4):e0175390. doi: 10.1371/journal.pone.0175390. eCollection 2017.


An Immortalized Human Dorsal Root Ganglion Cell Line Provides a Novel Context To Study Herpes Simplex Virus 1 Latency and Reactivation.

Thellman NM, Botting C, Madaj Z, Triezenberg SJ.

J Virol. 2017 May 26;91(12). pii: e00080-17. doi: 10.1128/JVI.00080-17. Print 2017 Jun 15.


Development and evaluation of a host-targeted antiviral that abrogates herpes simplex virus replication through modulation of arginine-associated metabolic pathways.

Sanchez MD, Ochoa AC, Foster TP.

Antiviral Res. 2016 Aug;132:13-25. doi: 10.1016/j.antiviral.2016.05.009. Epub 2016 May 15.


Harmine blocks herpes simplex virus infection through downregulating cellular NF-κB and MAPK pathways induced by oxidative stress.

Chen D, Su A, Fu Y, Wang X, Lv X, Xu W, Xu S, Wang H, Wu Z.

Antiviral Res. 2015 Nov;123:27-38. doi: 10.1016/j.antiviral.2015.09.003. Epub 2015 Sep 5.


The re-expression of the epigenetically silenced e-cadherin gene by a polyamine analogue lysine-specific demethylase-1 (LSD1) inhibitor in human acute myeloid leukemia cell lines.

Murray-Stewart T, Woster PM, Casero RA Jr.

Amino Acids. 2014 Mar;46(3):585-94. doi: 10.1007/s00726-013-1485-1. Epub 2013 Mar 19.


CDK9 inhibitor FIT-039 prevents replication of multiple DNA viruses.

Yamamoto M, Onogi H, Kii I, Yoshida S, Iida K, Sakai H, Abe M, Tsubota T, Ito N, Hosoya T, Hagiwara M.

J Clin Invest. 2014 Aug;124(8):3479-88. doi: 10.1172/JCI73805. Epub 2014 Jul 8.


Chromatin structure regulates human cytomegalovirus gene expression during latency, reactivation and lytic infection.

Sinclair J.

Biochim Biophys Acta. 2010 Mar-Apr;1799(3-4):286-95. doi: 10.1016/j.bbagrm.2009.08.001. Epub 2009 Aug 12. Review.


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