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Items: 1 to 20 of 142


MRP4-mediated regulation of intracellular cAMP and cGMP levels in trabecular meshwork cells and homeostasis of intraocular pressure.

Pattabiraman PP, Pecen PE, Rao PV.

Invest Ophthalmol Vis Sci. 2013 Mar 5;54(3):1636-49. doi: 10.1167/iovs.12-11107.


Multi-drug resistance protein 4 (MRP4)-mediated regulation of fibroblast cell migration reflects a dichotomous role of intracellular cyclic nucleotides.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Zhang W, Cheepala SB, Schuetz JD, Naren AP.

J Biol Chem. 2013 Feb 8;288(6):3786-94. doi: 10.1074/jbc.M112.435925. Epub 2012 Dec 21.


Connective tissue growth factor-mediated upregulation of neuromedin U expression in trabecular meshwork cells and its role in homeostasis of aqueous humor outflow.

Iyer P, Maddala R, Pattabiraman PP, Rao PV.

Invest Ophthalmol Vis Sci. 2012 Jul 26;53(8):4952-62. doi: 10.1167/iovs.12-9681.


Inhibition of MRP4 prevents and reverses pulmonary hypertension in mice.

Hara Y, Sassi Y, Guibert C, Gambaryan N, Dorfmüller P, Eddahibi S, Lompré AM, Humbert M, Hulot JS.

J Clin Invest. 2011 Jul;121(7):2888-97. doi: 10.1172/JCI45023. Epub 2011 Jun 13.


Role of lysophospholipid growth factors in the modulation of aqueous humor outflow facility.

Mettu PS, Deng PF, Misra UK, Gawdi G, Epstein DL, Rao PV.

Invest Ophthalmol Vis Sci. 2004 Jul;45(7):2263-71.


Elevated intraocular pressure induces Rho GTPase mediated contractile signaling in the trabecular meshwork.

Pattabiraman PP, Inoue T, Rao PV.

Exp Eye Res. 2015 Jul;136:29-33. doi: 10.1016/j.exer.2015.05.001. Epub 2015 May 5.


MRP4 Modulation of the Guanylate Cyclase-C/cGMP Pathway: Effects on Linaclotide-Induced Electrolyte Secretion and cGMP Efflux.

Tchernychev B, Ge P, Kessler MM, Solinga RM, Wachtel D, Tobin JV, Thomas SR, Lunte CE, Fretzen A, Hannig G, Bryant AP, Kurtz CB, Currie MG, Silos-Santiago I.

J Pharmacol Exp Ther. 2015 Oct;355(1):48-56. doi: 10.1124/jpet.115.224329. Epub 2015 Jul 27.


Reduction of cAMP and cGMP inhibitory effects in human platelets by MRP4-mediated transport.

Borgognone A, Pulcinelli FM.

Thromb Haemost. 2012 Nov;108(5):955-62. doi: 10.1160/TH12-04-0232. Epub 2012 Sep 26.


Modulation of aqueous humor outflow facility by the Rho kinase-specific inhibitor Y-27632.

Rao PV, Deng PF, Kumar J, Epstein DL.

Invest Ophthalmol Vis Sci. 2001 Apr;42(5):1029-37. Erratum in: Invest Ophthalmol Vis Sci 2001 Jul;42(8):1690.


Autotaxin-lysophosphatidic acid axis is a novel molecular target for lowering intraocular pressure.

Iyer P, Lalane R 3rd, Morris C, Challa P, Vann R, Rao PV.

PLoS One. 2012;7(8):e42627. doi: 10.1371/journal.pone.0042627. Epub 2012 Aug 20.


The role of calcium-independent phospholipase A2γ in modulation of aqueous humor drainage and Ca2+ sensitization of trabecular meshwork contraction.

Pattabiraman PP, Lih FB, Tomer KB, Rao PV.

Am J Physiol Cell Physiol. 2012 Apr 1;302(7):C979-91. doi: 10.1152/ajpcell.00396.2011. Epub 2012 Jan 11.


Guanylate cyclase activators, cell volume changes and IOP reduction.

Ellis DZ.

Cell Physiol Biochem. 2011;28(6):1145-54. doi: 10.1159/000335866. Epub 2011 Dec 16. Review.


Regulation of myosin light chain phosphorylation in the trabecular meshwork: role in aqueous humour outflow facility.

Rao PV, Deng P, Sasaki Y, Epstein DL.

Exp Eye Res. 2005 Feb;80(2):197-206.


Novel molecular insights into RhoA GTPase-induced resistance to aqueous humor outflow through the trabecular meshwork.

Zhang M, Maddala R, Rao PV.

Am J Physiol Cell Physiol. 2008 Nov;295(5):C1057-70. doi: 10.1152/ajpcell.00481.2007. Epub 2008 Sep 17.


NO-induced regulation of human trabecular meshwork cell volume and aqueous humor outflow facility involve the BKCa ion channel.

Dismuke WM, Mbadugha CC, Ellis DZ.

Am J Physiol Cell Physiol. 2008 Jun;294(6):C1378-86. doi: 10.1152/ajpcell.00363.2007. Epub 2008 Apr 2.


Effect of elevated intracellular cAMP levels on actomyosin contraction in bovine trabecular meshwork cells.

Ramachandran C, Patil RV, Sharif NA, Srinivas SP.

Invest Ophthalmol Vis Sci. 2011 Mar 18;52(3):1474-85. doi: 10.1167/iovs.10-6241.


Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation.

Wu J, Li G, Luna C, Spasojevic I, Epstein DL, Gonzalez P.

Invest Ophthalmol Vis Sci. 2012 Oct 1;53(11):7142-8. doi: 10.1167/iovs.12-9968.


PKA and actin play critical roles as downstream effectors in MRP4-mediated regulation of fibroblast migration.

Sinha C, Ren A, Arora K, Moon CS, Yarlagadda S, Woodrooffe K, Lin S, Schuetz JD, Ziady AG, Naren AP.

Cell Signal. 2015 Jul;27(7):1345-55. doi: 10.1016/j.cellsig.2015.03.022. Epub 2015 Apr 2.


Hic-5 Regulates Actin Cytoskeletal Reorganization and Expression of Fibrogenic Markers and Myocilin in Trabecular Meshwork Cells.

Pattabiraman PP, Rao PV.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5656-69. doi: 10.1167/iovs.15-17204.

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