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Items: 1 to 20 of 97

1.

Potent Inhibition of HIV-1 Reverse Transcriptase and Replication by Nonpseudoknot, "UCAA-motif" RNA Aptamers.

Whatley AS, Ditzler MA, Lange MJ, Biondi E, Sawyer AW, Chang JL, Franken JD, Burke DH.

Mol Ther Nucleic Acids. 2013 Feb 5;2:e71. doi: 10.1038/mtna.2012.62.

3.

RNA-protein interactions govern antiviral specificity and encapsidation of broad spectrum anti-HIV reverse transcriptase aptamers.

Lange MJ, Nguyen PD, Callaway MK, Johnson MC, Burke DH.

Nucleic Acids Res. 2017 Mar 6. doi: 10.1093/nar/gkx155. [Epub ahead of print]

PMID:
28334941
4.

High-throughput sequence analysis reveals structural diversity and improved potency among RNA inhibitors of HIV reverse transcriptase.

Ditzler MA, Lange MJ, Bose D, Bottoms CA, Virkler KF, Sawyer AW, Whatley AS, Spollen W, Givan SA, Burke DH.

Nucleic Acids Res. 2013 Feb 1;41(3):1873-84. doi: 10.1093/nar/gks1190. Epub 2012 Dec 14.

5.
6.

Aptamers that recognize drug-resistant HIV-1 reverse transcriptase.

Li N, Wang Y, Pothukuchy A, Syrett A, Husain N, Gopalakrisha S, Kosaraju P, Ellington AD.

Nucleic Acids Res. 2008 Dec;36(21):6739-51. doi: 10.1093/nar/gkn775. Epub 2008 Oct 23.

7.

Differential susceptibility of HIV-1 reverse transcriptase to inhibition by RNA aptamers in enzymatic reactions monitoring specific steps during genome replication.

Held DM, Kissel JD, Saran D, Michalowski D, Burke DH.

J Biol Chem. 2006 Sep 1;281(35):25712-22. Epub 2006 Jun 23.

8.

Cross-clade inhibition of recombinant human immunodeficiency virus type 1 (HIV-1), HIV-2, and simian immunodeficiency virus SIVcpz reverse transcriptases by RNA pseudoknot aptamers.

Held DM, Kissel JD, Thacker SJ, Michalowski D, Saran D, Ji J, Hardy RW, Rossi JJ, Burke DH.

J Virol. 2007 May;81(10):5375-84. Epub 2007 Feb 28.

9.

Broad-spectrum aptamer inhibitors of HIV reverse transcriptase closely mimic natural substrates.

Ditzler MA, Bose D, Shkriabai N, Marchand B, Sarafianos SG, Kvaratskhelia M, Burke DH.

Nucleic Acids Res. 2011 Oct;39(18):8237-47. doi: 10.1093/nar/gkr381. Epub 2011 Jul 3.

10.

Bent pseudoknots and novel RNA inhibitors of type 1 human immunodeficiency virus (HIV-1) reverse transcriptase.

Burke DH, Scates L, Andrews K, Gold L.

J Mol Biol. 1996 Dec 13;264(4):650-66.

PMID:
8980676
11.

Novel aptamer inhibitors of human immunodeficiency virus reverse transcriptase.

DeStefano JJ, Nair GR.

Oligonucleotides. 2008 Jun;18(2):133-44. doi: 10.1089/oli.2008.0103.

12.
13.

Endogenous expression of a high-affinity pseudoknot RNA aptamer suppresses replication of HIV-1.

Chaloin L, Lehmann MJ, Sczakiel G, Restle T.

Nucleic Acids Res. 2002 Sep 15;30(18):4001-8.

14.

Insight into HIV-1 reverse transcriptase-aptamer interaction from molecular dynamics simulations.

Aeksiri N, Songtawee N, Gleeson MP, Hannongbua S, Choowongkomon K.

J Mol Model. 2014 Aug;20(8):2380. doi: 10.1007/s00894-014-2380-8. Epub 2014 Jul 30.

PMID:
25073457
15.

Single-stranded DNA aptamer RT1t49 inhibits RT polymerase and RNase H functions of HIV type 1, HIV type 2, and SIVCPZ RTs.

Kissel JD, Held DM, Hardy RW, Burke DH.

AIDS Res Hum Retroviruses. 2007 May;23(5):699-708.

PMID:
17530996
17.

Selective inhibition of HIV-1 reverse transcriptase (HIV-1 RT) RNase H by small RNA hairpins and dumbbells.

Hannoush RN, Carriero S, Min KL, Damha MJ.

Chembiochem. 2004 Apr 2;5(4):527-33.

PMID:
15185377
18.
20.

Robust suppression of HIV replication by intracellularly expressed reverse transcriptase aptamers is independent of ribozyme processing.

Lange MJ, Sharma TK, Whatley AS, Landon LA, Tempesta MA, Johnson MC, Burke DH.

Mol Ther. 2012 Dec;20(12):2304-14. doi: 10.1038/mt.2012.158. Epub 2012 Sep 4.

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