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Items: 1 to 20 of 104

1.

Identification of acidic heterocycle-substituted 1H-pyrazolo[3,4-b]pyridines as soluble guanylate cyclase stimulators.

Griebenow N, Schirok H, Mittendorf J, Straub A, Follmann M, Stasch JP, Knorr A, Schlemmer KH, Redlich G.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1197-200. doi: 10.1016/j.bmcl.2013.01.028. Epub 2013 Jan 16.

PMID:
23385209
2.

NO-independent stimulators of soluble guanylate cyclase.

Straub A, Stasch JP, Alonso-Alija C, Benet-Buchholz J, Ducke B, Feurer A, Fürstner C.

Bioorg Med Chem Lett. 2001 Mar 26;11(6):781-4.

PMID:
11277519
3.

Synthesis of C-6 substituted pyrazolo[1,5-a]pyridines with potent activity against herpesviruses.

Allen SH, Johns BA, Gudmundsson KS, Freeman GA, Boyd FL Jr, Sexton CH, Selleseth DW, Creech KL, Moniri KR.

Bioorg Med Chem. 2006 Feb 15;14(4):944-54. Epub 2005 Oct 4.

PMID:
16213142
4.

Metabolites of orally active NO-independent pyrazolopyridine stimulators of soluble guanylate cyclase.

Straub A, Benet-Buckholz J, Fröde R, Kern A, Kohlsdorfer C, Schmitt P, Schwarz T, Siefert HM, Stasch JP.

Bioorg Med Chem. 2002 Jun;10(6):1711-7. Erratum in: Bioorg Med Chem. 2002 Sep;10(9):3075.

PMID:
11937330
5.

Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase.

Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G, Woo CK.

J Med Chem. 2001 Jan 4;44(1):78-93.

PMID:
11141091
6.

Pyrazolopyridines as potent PDE4B inhibitors: 5-heterocycle SAR.

Mitchell CJ, Ballantine SP, Coe DM, Cook CM, Delves CJ, Dowle MD, Edlin CD, Hamblin JN, Holman S, Johnson MR, Jones PS, Keeling SE, Kranz M, Lindvall M, Lucas FS, Neu M, Solanke YE, Somers DO, Trivedi NA, Wiseman JO.

Bioorg Med Chem Lett. 2010 Oct 1;20(19):5803-6. doi: 10.1016/j.bmcl.2010.07.136. Epub 2010 Aug 5.

PMID:
20732811
8.

Synthesis and anti-tumor activities of some new pyridines and pyrazolo[1,5-a]pyrimidines.

Ahmed OM, Mohamed MA, Ahmed RR, Ahmed SA.

Eur J Med Chem. 2009 Sep;44(9):3519-23. doi: 10.1016/j.ejmech.2009.03.042. Epub 2009 Apr 8.

PMID:
19398146
9.

Synthesis and biological evaluation of novel alkyl amide functionalized trifluoromethyl substituted pyrazolo[3,4-b]pyridine derivatives as potential anticancer agents.

Chavva K, Pillalamarri S, Banda V, Gautham S, Gaddamedi J, Yedla P, Kumar CG, Banda N.

Bioorg Med Chem Lett. 2013 Nov 1;23(21):5893-5. doi: 10.1016/j.bmcl.2013.08.089. Epub 2013 Sep 3.

PMID:
24060486
10.

Antibacterial profile against drug-resistant Staphylococcus epidermidis clinical strain and structure-activity relationship studies of 1H-pyrazolo[3,4-b]pyridine and thieno[2,3-b]pyridine derivatives.

Leal B, Afonso IF, Rodrigues CR, Abreu PA, Garrett R, Pinheiro LC, Azevedo AR, Borges JC, Vegi PF, Santos CC, da Silveira FC, Cabral LM, Frugulhetti IC, Bernardino AM, Santos DO, Castro HC.

Bioorg Med Chem. 2008 Sep 1;16(17):8196-204. doi: 10.1016/j.bmc.2008.07.035. Epub 2008 Jul 20.

PMID:
18701299
11.

Phosphodiesterase inhibitors. Part 6: design, synthesis, and structure-activity relationships of PDE4-inhibitory pyrazolo[1,5-a]pyridines with anti-inflammatory activity.

Kojima A, Takita S, Sumiya T, Ochiai K, Iwase K, Kishi T, Ohinata A, Yageta Y, Yasue T, Kohno Y.

Bioorg Med Chem Lett. 2013 Oct 1;23(19):5311-6. doi: 10.1016/j.bmcl.2013.07.069. Epub 2013 Aug 8.

PMID:
23988356
12.

Pyrazolo[1,5-a]pyrimidines as orally available inhibitors of cyclin-dependent kinase 2.

Paruch K, Dwyer MP, Alvarez C, Brown C, Chan TY, Doll RJ, Keertikar K, Knutson C, McKittrick B, Rivera J, Rossman R, Tucker G, Fischmann TO, Hruza A, Madison V, Nomeir AA, Wang Y, Lees E, Parry D, Sgambellone N, Seghezzi W, Schultz L, Shanahan F, Wiswell D, Xu X, Zhou Q, James RA, Paradkar VM, Park H, Rokosz LR, Stauffer TM, Guzi TJ.

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6220-3. Epub 2007 Sep 8.

PMID:
17904841
13.

Synthesis of novel substituted 2-phenylpyrazolopyridines with potent activity against herpesviruses.

Gudmundsson KS, Johns BA, Wang Z, Turner EM, Allen SH, Freeman GA, Boyd FL Jr, Sexton CJ, Selleseth DW, Moniri KR, Creech KL.

Bioorg Med Chem. 2005 Sep 15;13(18):5346-61.

PMID:
16039862
15.

Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.

Lin R, Connolly PJ, Lu Y, Chiu G, Li S, Yu Y, Huang S, Li X, Emanuel SL, Middleton SA, Gruninger RH, Adams M, Fuentes-Pesquera AR, Greenberger LM.

Bioorg Med Chem Lett. 2007 Aug 1;17(15):4297-302. Epub 2007 May 16.

PMID:
17532631
16.

New pyrazolo[3,4-b]pyridones as selective A(1) adenosine receptor antagonists: synthesis, biological evaluation and molecular modelling studies.

Fossa P, Pestarino M, Menozzi G, Mosti L, Schenone S, Ranise A, Bondavalli F, Trincavelli ML, Lucacchini A, Martini C.

Org Biomol Chem. 2005 Jun 21;3(12):2262-70. Epub 2005 May 19. Erratum in: Org Biomol Chem. 2005 Oct 21;3(20):3826.

PMID:
16010360
17.

Antileishmanial pyrazolopyridine derivatives: synthesis and structure-activity relationship analysis.

de Mello H, Echevarria A, Bernardino AM, Canto-Cavalheiro M, Leon LL.

J Med Chem. 2004 Oct 21;47(22):5427-32.

PMID:
15481980
18.

BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro.

Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S, Cellek S.

J Urol. 2003 Feb;169(2):761-6.

PMID:
12544359
19.

Hantzsch synthesis of pyrazolo[1',2':1,2]pyrazolo[3,4-b]pyridines: partial agonists of the calcitonin receptor.

Boros EE, Cowan DJ, Cox RF, Mebrahtu MM, Rabinowitz MH, Thompson JB, Wolfe LA 3rd.

J Org Chem. 2005 Jun 24;70(13):5331-4.

PMID:
15960543
20.

Development of 3-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine derivatives as novel Mycobacterium tuberculosis pantothenate synthetase inhibitors.

Samala G, Devi PB, Nallangi R, Yogeeswari P, Sriram D.

Eur J Med Chem. 2013 Nov;69:356-64. doi: 10.1016/j.ejmech.2013.08.036. Epub 2013 Sep 12.

PMID:
24077526

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