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Items: 1 to 20 of 80

1.

Impaired glycolytic metabolism causes chondrocyte hypertrophy-like changes via promotion of phospho-Smad1/5/8 translocation into nucleus.

Nishida T, Kubota S, Aoyama E, Takigawa M.

Osteoarthritis Cartilage. 2013 May;21(5):700-9. doi: 10.1016/j.joca.2013.01.013. Epub 2013 Feb 4.

2.

The high affinity ALK1-ligand BMP9 induces a hypertrophy-like state in chondrocytes that is antagonized by TGFβ1.

van Caam A, Blaney Davidson E, Garcia de Vinuesa A, van Geffen E, van den Berg W, Goumans MJ, ten Dijke P, van der Kraan P.

Osteoarthritis Cartilage. 2015 Jun;23(6):985-95. doi: 10.1016/j.joca.2015.02.007. Epub 2015 Feb 12.

4.

Matrilin-3 inhibits chondrocyte hypertrophy as a bone morphogenetic protein-2 antagonist.

Yang X, Trehan SK, Guan Y, Sun C, Moore DC, Jayasuriya CT, Chen Q.

J Biol Chem. 2014 Dec 12;289(50):34768-79. doi: 10.1074/jbc.M114.583104. Epub 2014 Oct 20.

5.

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8.

van den Bosch MH, Blom AB, van Lent PL, van Beuningen HM, Blaney Davidson EN, van der Kraan PM, van den Berg WB.

Cell Signal. 2014 May;26(5):951-8. doi: 10.1016/j.cellsig.2014.01.021. Epub 2014 Jan 23.

PMID:
24463008
6.

Smad signaling determines chondrogenic differentiation of bone-marrow-derived mesenchymal stem cells: inhibition of Smad1/5/8P prevents terminal differentiation and calcification.

Hellingman CA, Davidson EN, Koevoet W, Vitters EL, van den Berg WB, van Osch GJ, van der Kraan PM.

Tissue Eng Part A. 2011 Apr;17(7-8):1157-67. doi: 10.1089/ten.TEA.2010.0043. Epub 2011 Jan 17.

PMID:
21142619
7.

Liver X Receptor activation delays chondrocyte hypertrophy during endochondral bone growth.

Sun MM, Beier F.

Osteoarthritis Cartilage. 2014 Jul;22(7):996-1006. doi: 10.1016/j.joca.2014.05.003. Epub 2014 May 20.

8.

Fluoride promotes viability and differentiation of osteoblast-like Saos-2 cells via BMP/Smads signaling pathway.

Huo L, Liu K, Pei J, Yang Y, Ye Y, Liu Y, Sun J, Han H, Xu W, Gao Y.

Biol Trace Elem Res. 2013 Oct;155(1):142-9. doi: 10.1007/s12011-013-9770-0. Epub 2013 Aug 7.

9.

Restriction of spontaneous and prednisolone-induced leptin production to dedifferentiated state in human hip OA chondrocytes: role of Smad1 and β-catenin activation.

Charlier E, Malaise O, Zeddou M, Neuville S, Cobraiville G, Deroyer C, Sanchez C, Gillet P, Kurth W, de Seny D, Relic B, Malaise MG.

Osteoarthritis Cartilage. 2016 Feb;24(2):315-24. doi: 10.1016/j.joca.2015.08.002. Epub 2015 Aug 28.

10.

Functions of transforming growth factor-beta family type I receptors and Smad proteins in the hypertrophic maturation and osteoblastic differentiation of chondrocytes.

Valcourt U, Gouttenoire J, Moustakas A, Herbage D, Mallein-Gerin F.

J Biol Chem. 2002 Sep 13;277(37):33545-58. Epub 2002 Jun 24.

11.

BAPX-1/NKX-3.2 acts as a chondrocyte hypertrophy molecular switch in osteoarthritis.

Caron MM, Emans PJ, Surtel DA, van der Kraan PM, van Rhijn LW, Welting TJ.

Arthritis Rheumatol. 2015 Nov;67(11):2944-56. doi: 10.1002/art.39293.

12.

A novel role for GADD45beta as a mediator of MMP-13 gene expression during chondrocyte terminal differentiation.

Ijiri K, Zerbini LF, Peng H, Correa RG, Lu B, Walsh N, Zhao Y, Taniguchi N, Huang XL, Otu H, Wang H, Wang JF, Komiya S, Ducy P, Rahman MU, Flavell RA, Gravallese EM, Oettgen P, Libermann TA, Goldring MB.

J Biol Chem. 2005 Nov 18;280(46):38544-55. Epub 2005 Sep 2.

13.

Bone morphogenetic protein 4 promotes mammalian oogonial stem cell differentiation via Smad1/5/8 signaling.

Park ES, Woods DC, Tilly JL.

Fertil Steril. 2013 Nov;100(5):1468-75. doi: 10.1016/j.fertnstert.2013.07.1978. Epub 2013 Aug 28.

14.

Parathyroid hormone-related peptide represses chondrocyte hypertrophy through a protein phosphatase 2A/histone deacetylase 4/MEF2 pathway.

Kozhemyakina E, Cohen T, Yao TP, Lassar AB.

Mol Cell Biol. 2009 Nov;29(21):5751-62. doi: 10.1128/MCB.00415-09. Epub 2009 Aug 24.

15.

TGFβ inhibition during expansion phase increases the chondrogenic re-differentiation capacity of human articular chondrocytes.

Narcisi R, Signorile L, Verhaar JA, Giannoni P, van Osch GJ.

Osteoarthritis Cartilage. 2012 Oct;20(10):1152-60. doi: 10.1016/j.joca.2012.06.010. Epub 2012 Jul 4.

16.

ALK1 opposes ALK5/Smad3 signaling and expression of extracellular matrix components in human chondrocytes.

Finnson KW, Parker WL, ten Dijke P, Thorikay M, Philip A.

J Bone Miner Res. 2008 Jun;23(6):896-906. doi: 10.1359/jbmr.080209.

17.

Consequences of chondrocyte hypertrophy on osteoarthritic cartilage: potential effect on angiogenesis.

Pesesse L, Sanchez C, Delcour JP, Bellahcène A, Baudouin C, Msika P, Henrotin Y.

Osteoarthritis Cartilage. 2013 Dec;21(12):1913-23. doi: 10.1016/j.joca.2013.08.018. Epub 2013 Aug 22.

18.

Transcriptional factors smad1 and smad9 act redundantly to mediate zebrafish ventral specification downstream of smad5.

Wei CY, Wang HP, Zhu ZY, Sun YH.

J Biol Chem. 2014 Mar 7;289(10):6604-18. doi: 10.1074/jbc.M114.549758. Epub 2014 Jan 31.

19.

SMAD1/5 signaling in the early equine placenta regulates trophoblast differentiation and chorionic gonadotropin secretion.

Cabrera-Sharp V, Read JE, Richardson S, Kowalski AA, Antczak DF, Cartwright JE, Mukherjee A, de Mestre AM.

Endocrinology. 2014 Aug;155(8):3054-64. doi: 10.1210/en.2013-2116. Epub 2014 May 21.

20.

Smad 1/5 is involved in bone morphogenetic protein-2-induced odontoblastic differentiation in human dental pulp cells.

Qin W, Yang F, Deng R, Li D, Song Z, Tian Y, Wang R, Ling J, Lin Z.

J Endod. 2012 Jan;38(1):66-71. doi: 10.1016/j.joen.2011.09.025. Epub 2011 Nov 12.

PMID:
22152623

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