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WNK signaling is involved in neural development via Lhx8/Awh expression.

Sato A, Shibuya H.

PLoS One. 2013;8(1):e55301. doi: 10.1371/journal.pone.0055301. Epub 2013 Jan 30.


The CUL3-KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction.

Ohta A, Schumacher FR, Mehellou Y, Johnson C, Knebel A, Macartney TJ, Wood NT, Alessi DR, Kurz T.

Biochem J. 2013 Apr 1;451(1):111-22. doi: 10.1042/BJ20121903.


SPAK/OSR1 regulate NKCC1 and WNK activity: analysis of WNK isoform interactions and activation by T-loop trans-autophosphorylation.

Thastrup JO, Rafiqi FH, Vitari AC, Pozo-Guisado E, Deak M, Mehellou Y, Alessi DR.

Biochem J. 2012 Jan 1;441(1):325-37. doi: 10.1042/BJ20111879.


WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.

Susa K, Sohara E, Takahashi D, Okado T, Rai T, Uchida S.

Biochem Biophys Res Commun. 2017 Sep 23;491(3):727-732. doi: 10.1016/j.bbrc.2017.07.121. Epub 2017 Jul 22.


Effect of heterozygous deletion of WNK1 on the WNK-OSR1/ SPAK-NCC/NKCC1/NKCC2 signal cascade in the kidney and blood vessels.

Susa K, Kita S, Iwamoto T, Yang SS, Lin SH, Ohta A, Sohara E, Rai T, Sasaki S, Alessi DR, Uchida S.

Clin Exp Nephrol. 2012 Aug;16(4):530-8.


Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.

Roy A, Goodman JH, Begum G, Donnelly BF, Pittman G, Weinman EJ, Sun D, Subramanya AR.

Am J Physiol Renal Physiol. 2015 Feb 15;308(4):F366-76. doi: 10.1152/ajprenal.00612.2014. Epub 2014 Dec 4.


Impaired degradation of WNK1 and WNK4 kinases causes PHAII in mutant KLHL3 knock-in mice.

Susa K, Sohara E, Rai T, Zeniya M, Mori Y, Mori T, Chiga M, Nomura N, Nishida H, Takahashi D, Isobe K, Inoue Y, Takeishi K, Takeda N, Sasaki S, Uchida S.

Hum Mol Genet. 2014 Oct 1;23(19):5052-60. doi: 10.1093/hmg/ddu217. Epub 2014 May 12.


WNK1 regulates phosphorylation of cation-chloride-coupled cotransporters via the STE20-related kinases, SPAK and OSR1.

Moriguchi T, Urushiyama S, Hisamoto N, Iemura S, Uchida S, Natsume T, Matsumoto K, Shibuya H.

J Biol Chem. 2005 Dec 30;280(52):42685-93. Epub 2005 Oct 31.


Identification of the WNK-SPAK/OSR1 signaling pathway in rodent and human lenses.

Vorontsova I, Lam L, Delpire E, Lim J, Donaldson P.

Invest Ophthalmol Vis Sci. 2014 Dec 16;56(1):310-21. doi: 10.1167/iovs.14-15911.


WNK kinases regulate thiazide-sensitive Na-Cl cotransport.

Yang CL, Angell J, Mitchell R, Ellison DH.

J Clin Invest. 2003 Apr;111(7):1039-45.


Actions of the protein kinase WNK1 on endothelial cells are differentially mediated by its substrate kinases OSR1 and SPAK.

Dbouk HA, Weil LM, Perera GK, Dellinger MT, Pearson G, Brekken RA, Cobb MH.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):15999-6004. doi: 10.1073/pnas.1419057111. Epub 2014 Oct 31.


Dietary electrolyte-driven responses in the renal WNK kinase pathway in vivo.

O'Reilly M, Marshall E, Macgillivray T, Mittal M, Xue W, Kenyon CJ, Brown RW.

J Am Soc Nephrol. 2006 Sep;17(9):2402-13. Epub 2006 Aug 9.


Kelch-like 3/Cullin 3 ubiquitin ligase complex and WNK signaling in salt-sensitive hypertension and electrolyte disorder.

Sohara E, Uchida S.

Nephrol Dial Transplant. 2016 Sep;31(9):1417-24. doi: 10.1093/ndt/gfv259. Epub 2015 Jul 6. Review.


WNK Kinases in Development and Disease.

Rodan AR, Jenny A.

Curr Top Dev Biol. 2017;123:1-47. doi: 10.1016/bs.ctdb.2016.08.004. Epub 2016 Sep 28. Review.


The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.

Yang CL, Zhu X, Ellison DH.

J Clin Invest. 2007 Nov;117(11):3403-11.


WNK kinases influence TRPV4 channel function and localization.

Fu Y, Subramanya A, Rozansky D, Cohen DM.

Am J Physiol Renal Physiol. 2006 Jun;290(6):F1305-14. Epub 2006 Jan 10.


SPAK deficiency corrects pseudohypoaldosteronism II caused by WNK4 mutation.

Chu PY, Cheng CJ, Wu YC, Fang YW, Chau T, Uchida S, Sasaki S, Yang SS, Lin SH.

PLoS One. 2013 Sep 11;8(9):e72969. doi: 10.1371/journal.pone.0072969. eCollection 2013.


WNK4 is an essential effector of anterior formation in FGF signaling.

Shimizu M, Goto T, Sato A, Shibuya H.

Genes Cells. 2013 Jun;18(6):442-9. doi: 10.1111/gtc.12048. Epub 2013 Mar 21.


The regulation of salt transport and blood pressure by the WNK-SPAK/OSR1 signalling pathway.

Richardson C, Alessi DR.

J Cell Sci. 2008 Oct 15;121(Pt 20):3293-304. doi: 10.1242/jcs.029223. Review.

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