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TLR7 stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells.

Edwards S, Jones C, Leishman AJ, Young BW, Matsui H, Tomizawa H, Murray CM, Biffen M.

J Immunol. 2013 Mar 15;190(6):2585-92. doi: 10.4049/jimmunol.1200780.


TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production.

Hart OM, Athie-Morales V, O'Connor GM, Gardiner CM.

J Immunol. 2005 Aug 1;175(3):1636-42.


Mechanism of action of inhibition of allergic immune responses by a novel antedrug TLR7 agonist.

Matsui H, Tomizawa H, Eiho K, Kashiwazaki Y, Edwards S, Biffen M, Bell JP, Bahl A, Leishman AJ, Murray CM, Takaku H, Ueda Y.

J Immunol. 2012 Dec 1;189(11):5194-205. doi: 10.4049/jimmunol.1101331.


Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells.

Lombardi V, Van Overtvelt L, Horiot S, Moingeon P.

J Immunol. 2009 Mar 15;182(6):3372-9. doi: 10.4049/jimmunol.0801969.


Recognition of Borrelia burgdorferi, the Lyme disease spirochete, by TLR7 and TLR9 induces a type I IFN response by human immune cells.

Petzke MM, Brooks A, Krupna MA, Mordue D, Schwartz I.

J Immunol. 2009 Oct 15;183(8):5279-92. doi: 10.4049/jimmunol.0901390.


Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells.

Forward NA, Furlong SJ, Yang Y, Lin TJ, Hoskin DW.

J Leukoc Biol. 2010 Jan;87(1):117-25. doi: 10.1189/jlb.0908559.


Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN.

Bekeredjian-Ding IB, Wagner M, Hornung V, Giese T, Schnurr M, Endres S, Hartmann G.

J Immunol. 2005 Apr 1;174(7):4043-50. Erratum in: J Immunol. 2005 May 1;174(9):5884. Berkeredjian-Ding, Isabelle Béatrice [corrected to Bekeredjian-Ding, Isabelle Béatrice].


Synthetic TLR agonists reveal functional differences between human TLR7 and TLR8.

Gorden KB, Gorski KS, Gibson SJ, Kedl RM, Kieper WC, Qiu X, Tomai MA, Alkan SS, Vasilakos JP.

J Immunol. 2005 Feb 1;174(3):1259-68.


Toll-like receptor ligands modulate dendritic cells to augment cytomegalovirus- and HIV-1-specific T cell responses.

Loré K, Betts MR, Brenchley JM, Kuruppu J, Khojasteh S, Perfetto S, Roederer M, Seder RA, Koup RA.

J Immunol. 2003 Oct 15;171(8):4320-8.


IFN-beta1a inhibits the secretion of Th17-polarizing cytokines in human dendritic cells via TLR7 up-regulation.

Zhang X, Jin J, Tang Y, Speer D, Sujkowska D, Markovic-Plese S.

J Immunol. 2009 Mar 15;182(6):3928-36. doi: 10.4049/jimmunol.0802226.


Human gammadelta T cells modulate the mite allergen-specific T-helper type 2-skewed immunity.

Korematsu S, Tanaka Y, Nagakura T, Minato N, Izumi T.

Clin Exp Allergy. 2007 Nov;37(11):1681-7.


IFN-alpha skews monocyte differentiation into Toll-like receptor 7-expressing dendritic cells with potent functional activities.

Mohty M, Vialle-Castellano A, Nunes JA, Isnardon D, Olive D, Gaugler B.

J Immunol. 2003 Oct 1;171(7):3385-93.


T cells from human allergen-induced late asthmatic responses express IL-12 receptor beta 2 subunit mRNA and respond to IL-12 in vitro.

Varga EM, Wachholz P, Nouri-Aria KT, Verhoef A, Corrigan CJ, Till SJ, Durham SR.

J Immunol. 2000 Sep 1;165(5):2877-85.


TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN.

Di Domizio J, Blum A, Gallagher-Gambarelli M, Molens JP, Chaperot L, Plumas J.

Blood. 2009 Aug 27;114(9):1794-802. doi: 10.1182/blood-2009-04-216770.


Allergen-induced cytokine production in atopic disease and its relationship to disease severity.

Leonard C, Tormey V, Burke C, Poulter LW.

Am J Respir Cell Mol Biol. 1997 Sep;17(3):368-75.


Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.

Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K.

J Immunol. 2011 Mar 1;186(5):3104-12. doi: 10.4049/jimmunol.1002599.


IFN-alpha regulates TLR-dependent gene expression of IFN-alpha, IFN-beta, IL-28, and IL-29.

Sirén J, Pirhonen J, Julkunen I, Matikainen S.

J Immunol. 2005 Feb 15;174(4):1932-7.

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