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Items: 1 to 20 of 100

1.

Small-molecule inhibitors targeting G-protein-coupled Rho guanine nucleotide exchange factors.

Shang X, Marchioni F, Evelyn CR, Sipes N, Zhou X, Seibel W, Wortman M, Zheng Y.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3155-60. doi: 10.1073/pnas.1212324110. Epub 2013 Feb 4.

2.

High-throughput screening for small-molecule inhibitors of LARG-stimulated RhoA nucleotide binding via a novel fluorescence polarization assay.

Evelyn CR, Ferng T, Rojas RJ, Larsen MJ, Sondek J, Neubig RR.

J Biomol Screen. 2009 Feb;14(2):161-72. doi: 10.1177/1087057108328761. Epub 2009 Feb 4.

3.

Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG).

Jaiswal M, Gremer L, Dvorsky R, Haeusler LC, Cirstea IC, Uhlenbrock K, Ahmadian MR.

J Biol Chem. 2011 May 20;286(20):18202-12. doi: 10.1074/jbc.M111.226431. Epub 2011 Mar 28.

4.

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.

Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ.

J Biol Chem. 2001 Jul 20;276(29):27145-51. Epub 2001 May 23.

5.
6.

Structural determinants of RhoA binding and nucleotide exchange in leukemia-associated Rho guanine-nucleotide exchange factor.

Kristelly R, Gao G, Tesmer JJ.

J Biol Chem. 2004 Nov 5;279(45):47352-62. Epub 2004 Aug 25.

7.
8.

The semaphorin receptor plexin-B1 signals through a direct interaction with the Rho-specific nucleotide exchange factor, LARG.

Aurandt J, Vikis HG, Gutkind JS, Ahn N, Guan KL.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12085-90. Epub 2002 Aug 26.

9.

Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.

Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y.

J Biol Chem. 2004 Jan 30;279(5):3777-86. Epub 2003 Nov 3.

10.

A conserved hydrophobic surface of the LARG pleckstrin homology domain is critical for RhoA activation in cells.

Aittaleb M, Gao G, Evelyn CR, Neubig RR, Tesmer JJ.

Cell Signal. 2009 Nov;21(11):1569-78. doi: 10.1016/j.cellsig.2009.06.003. Epub 2009 Jun 26.

11.

Rational design of Rho GTPase-targeting inhibitors.

Shang X, Zheng Y.

Methods Mol Biol. 2012;928:29-38. doi: 10.1007/978-1-62703-008-3_3.

PMID:
22956131
12.

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF.

Zheng M, Cierpicki T, Momotani K, Artamonov MV, Derewenda U, Bushweller JH, Somlyo AV, Derewenda ZS.

BMC Struct Biol. 2009 May 21;9:36. doi: 10.1186/1472-6807-9-36.

13.

The guanine nucleotide exchange factor Tiam1: a Janus-faced molecule in cellular signaling.

Boissier P, Huynh-Do U.

Cell Signal. 2014 Mar;26(3):483-91. doi: 10.1016/j.cellsig.2013.11.034. Epub 2013 Dec 2. Review.

PMID:
24308970
15.

Identification and characterization of a novel Rho-specific guanine nucleotide exchange factor.

Blomquist A, Schwörer G, Schablowski H, Psoma A, Lehnen M, Jakobs KH, Rümenapp U.

Biochem J. 2000 Dec 1;352 Pt 2:319-25.

16.

XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC.

Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K.

J Biol Chem. 2002 Nov 8;277(45):42964-72. Epub 2002 Sep 6.

17.

The molecular basis of RhoA specificity in the guanine nucleotide exchange factor PDZ-RhoGEF.

Oleksy A, Opaliński Ł, Derewenda U, Derewenda ZS, Otlewski J.

J Biol Chem. 2006 Oct 27;281(43):32891-7. Epub 2006 Sep 5.

18.

Recognition and activation of Rho GTPases by Vav1 and Vav2 guanine nucleotide exchange factors.

Heo J, Thapar R, Campbell SL.

Biochemistry. 2005 May 3;44(17):6573-85.

PMID:
15850391
20.

Identification of the first Rho-GEF inhibitor, TRIPalpha, which targets the RhoA-specific GEF domain of Trio.

Schmidt S, Diriong S, Méry J, Fabbrizio E, Debant A.

FEBS Lett. 2002 Jul 17;523(1-3):35-42.

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