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Growth differentiation factor 9:bone morphogenetic protein 15 heterodimers are potent regulators of ovarian functions.

Peng J, Li Q, Wigglesworth K, Rangarajan A, Kattamuri C, Peterson RT, Eppig JJ, Thompson TB, Matzuk MM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E776-85. doi: 10.1073/pnas.1218020110. Epub 2013 Feb 4.


Effects of MiR-375-BMPR2 as a Key Factor Downstream of BMP15/GDF9 on the Smad1/5/8 and Smad2/3 Signaling Pathways.

Liu C, Yuan B, Chen H, Xu M, Sun X, Xu J, Gao Y, Chen C, Jiang H, Zhang J.

Cell Physiol Biochem. 2018;46(1):213-225. doi: 10.1159/000488424. Epub 2018 Mar 21.


Cumulin, an Oocyte-secreted Heterodimer of the Transforming Growth Factor-β Family, Is a Potent Activator of Granulosa Cells and Improves Oocyte Quality.

Mottershead DG, Sugimura S, Al-Musawi SL, Li JJ, Richani D, White MA, Martin GA, Trotta AP, Ritter LJ, Shi J, Mueller TD, Harrison CA, Gilchrist RB.

J Biol Chem. 2015 Sep 25;290(39):24007-20. doi: 10.1074/jbc.M115.671487. Epub 2015 Aug 8.


Amino acid 72 of mouse and human GDF9 mature domain is responsible for altered homodimer bioactivities but has subtle effects on GDF9:BMP15 heterodimer activities.

Peng J, Wigglesworth K, Rangarajan A, Eppig JJ, Thompson TB, Matzuk MM.

Biol Reprod. 2014 Dec;91(6):142. doi: 10.1095/biolreprod.114.123158. Epub 2014 Sep 24.


Synergistic roles of bone morphogenetic protein 15 and growth differentiation factor 9 in ovarian function.

Yan C, Wang P, DeMayo J, DeMayo FJ, Elvin JA, Carino C, Prasad SV, Skinner SS, Dunbar BS, Dube JL, Celeste AJ, Matzuk MM.

Mol Endocrinol. 2001 Jun;15(6):854-66.


Regulatory Role of miRNA-375 in Expression of BMP15/GDF9 Receptors and its Effect on Proliferation and Apoptosis of Bovine Cumulus Cells.

Chen H, Liu C, Jiang H, Gao Y, Xu M, Wang J, Liu S, Fu Y, Sun X, Xu J, Zhang J, Dai L.

Cell Physiol Biochem. 2017;41(2):439-450. doi: 10.1159/000456597. Epub 2017 Jan 27.


Evolutionary origin of bone morphogenetic protein 15 and growth and differentiation factor 9 and differential selective pressure between mono- and polyovulating species.

Monestier O, Servin B, Auclair S, Bourquard T, Poupon A, Pascal G, Fabre S.

Biol Reprod. 2014 Oct;91(4):83. doi: 10.1095/biolreprod.114.119735. Epub 2014 Aug 6.


The fundamental role of bone morphogenetic protein 15 in ovarian function and its involvement in female fertility disorders.

Persani L, Rossetti R, Di Pasquale E, Cacciatore C, Fabre S.

Hum Reprod Update. 2014 Nov-Dec;20(6):869-83. doi: 10.1093/humupd/dmu036. Epub 2014 Jun 30. Review.


Investigations of TGF-β signaling in preantral follicles of female mice reveal differential roles for bone morphogenetic protein 15.

Fenwick MA, Mora JM, Mansour YT, Baithun C, Franks S, Hardy K.

Endocrinology. 2013 Sep;154(9):3423-36. doi: 10.1210/en.2012-2251. Epub 2013 Jun 19.


Effects of growth differentiation factor 9 and bone morphogenetic protein 15 on the in vitro maturation of porcine oocytes.

Lin ZL, Li YH, Xu YN, Wang QL, Namgoong S, Cui XS, Kim NH.

Reprod Domest Anim. 2014 Apr;49(2):219-27. doi: 10.1111/rda.12254. Epub 2013 Dec 9.


Signalling pathways mediating specific synergistic interactions between GDF9 and BMP15.

Mottershead DG, Ritter LJ, Gilchrist RB.

Mol Hum Reprod. 2012 Mar;18(3):121-8. doi: 10.1093/molehr/gar056. Epub 2011 Sep 12.


Signalling pathways involved in the cooperative effects of ovine and murine GDF9+BMP15-stimulated thymidine uptake by rat granulosa cells.

Reader KL, Heath DA, Lun S, McIntosh CJ, Western AH, Littlejohn RP, McNatty KP, Juengel JL.

Reproduction. 2011 Jul;142(1):123-31. doi: 10.1530/REP-10-0490. Epub 2011 Apr 7.


The proregion of mouse BMP15 regulates the cooperative interactions of BMP15 and GDF9.

McIntosh CJ, Lun S, Lawrence S, Western AH, McNatty KP, Juengel JL.

Biol Reprod. 2008 Nov;79(5):889-96. doi: 10.1095/biolreprod.108.068163. Epub 2008 Jul 16.


Increased GDF9 and BMP15 mRNA levels in cumulus granulosa cells correlate with oocyte maturation, fertilization, and embryo quality in humans.

Li Y, Li RQ, Ou SB, Zhang NF, Ren L, Wei LN, Zhang QX, Yang DZ.

Reprod Biol Endocrinol. 2014 Aug 20;12:81. doi: 10.1186/1477-7827-12-81.


Estrogen promotes the development of mouse cumulus cells in coordination with oocyte-derived GDF9 and BMP15.

Sugiura K, Su YQ, Li Q, Wigglesworth K, Matzuk MM, Eppig JJ.

Mol Endocrinol. 2010 Dec;24(12):2303-14. doi: 10.1210/me.2010-0260. Epub 2010 Nov 3.


Oocyte-Derived Factors (GDF9 and BMP15) and FSH Regulate AMH Expression Via Modulation of H3K27AC in Granulosa Cells.

Roy S, Gandra D, Seger C, Biswas A, Kushnir VA, Gleicher N, Kumar TR, Sen A.

Endocrinology. 2018 Sep 1;159(9):3433-3445. doi: 10.1210/en.2018-00609.


Oocyte expression, secretion and somatic cell interaction of mouse bone morphogenetic protein 15 during the peri-ovulatory period.

Mester B, Ritter LJ, Pitman JL, Bibby AH, Gilchrist RB, McNatty KP, Juengel JL, McIntosh CJ.

Reprod Fertil Dev. 2015 Jun;27(5):801-11. doi: 10.1071/RD13336.


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