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Items: 1 to 20 of 146

1.

Enhancing the function of alpha5-subunit-containing GABAA receptors promotes action potential firing of neocortical neurons during up-states.

Drexler B, Zinser S, Huang S, Poe MM, Rudolph U, Cook JM, Antkowiak B.

Eur J Pharmacol. 2013 Mar 5;703(1-3):18-24. doi: 10.1016/j.ejphar.2013.01.034. Epub 2013 Feb 1.

2.

Selective targeting of the α5-subunit of GABAA receptors relaxes airway smooth muscle and inhibits cellular calcium handling.

Gallos G, Yocum GT, Siviski ME, Yim PD, Fu XW, Poe MM, Cook JM, Harrison N, Perez-Zoghbi J, Emala CW Sr.

Am J Physiol Lung Cell Mol Physiol. 2015 May 1;308(9):L931-42. doi: 10.1152/ajplung.00107.2014. Epub 2015 Feb 6.

3.

Anxiolytic-like effects of 8-acetylene imidazobenzodiazepines in a rhesus monkey conflict procedure.

Fischer BD, Licata SC, Edwankar RV, Wang ZJ, Huang S, He X, Yu J, Zhou H, Johnson EM Jr, Cook JM, Furtmüller R, Ramerstorfer J, Sieghart W, Roth BL, Majumder S, Rowlett JK.

Neuropharmacology. 2010 Dec;59(7-8):612-8. doi: 10.1016/j.neuropharm.2010.08.011. Epub 2010 Aug 18.

4.

A Pharmacogenetic 'Restriction-of-Function' Approach Reveals Evidence for Anxiolytic-Like Actions Mediated by α5-Containing GABAA Receptors in Mice.

Behlke LM, Foster RA, Liu J, Benke D, Benham RS, Nathanson AJ, Yee BK, Zeilhofer HU, Engin E, Rudolph U.

Neuropsychopharmacology. 2016 Sep;41(10):2492-501. doi: 10.1038/npp.2016.49. Epub 2016 Apr 12.

5.

Ester to amide substitution improves selectivity, efficacy and kinetic behavior of a benzodiazepine positive modulator of GABAA receptors containing the α5 subunit.

Stamenić TT, Poe MM, Rehman S, Santrač A, Divović B, Scholze P, Ernst M, Cook JM, Savić MM.

Eur J Pharmacol. 2016 Nov 15;791:433-443. doi: 10.1016/j.ejphar.2016.09.016. Epub 2016 Sep 14.

6.

Requirement of alpha5-GABAA receptors for the development of tolerance to the sedative action of diazepam in mice.

van Rijnsoever C, Täuber M, Choulli MK, Keist R, Rudolph U, Mohler H, Fritschy JM, Crestani F.

J Neurosci. 2004 Jul 28;24(30):6785-90.

7.
8.

Novel positive allosteric modulators of GABAA receptors: do subtle differences in activity at alpha1 plus alpha5 versus alpha2 plus alpha3 subunits account for dissimilarities in behavioral effects in rats?

Savić MM, Majumder S, Huang S, Edwankar RV, Furtmüller R, Joksimović S, Clayton T Sr, Ramerstorfer J, Milinković MM, Roth BL, Sieghart W, Cook JM.

Prog Neuropsychopharmacol Biol Psychiatry. 2010 Mar 17;34(2):376-86. doi: 10.1016/j.pnpbp.2010.01.004. Epub 2010 Jan 13.

9.

Sh-I-048A, an in vitro non-selective super-agonist at the benzodiazepine site of GABAA receptors: the approximated activation of receptor subtypes may explain behavioral effects.

Obradović ALj, Joksimović S, Poe MM, Ramerstorfer J, Varagic Z, Namjoshi O, Batinić B, Radulović T, Marković B, Roth BL, Sieghart W, Cook JM, Savić MM.

Brain Res. 2014 Mar 20;1554:36-48. doi: 10.1016/j.brainres.2014.01.036. Epub 2014 Jan 25.

10.

Imidazenil and diazepam increase locomotor activity in mice exposed to protracted social isolation.

Pinna G, Agis-Balboa RC, Zhubi A, Matsumoto K, Grayson DR, Costa E, Guidotti A.

Proc Natl Acad Sci U S A. 2006 Mar 14;103(11):4275-80. Epub 2006 Mar 6.

11.

Imidazenil: a low efficacy agonist at alpha1- but high efficacy at alpha5-GABAA receptors fail to show anticonvulsant cross tolerance to diazepam or zolpidem.

Auta J, Impagnatiello F, Kadriu B, Guidotti A, Costa E.

Neuropharmacology. 2008 Aug;55(2):148-53. doi: 10.1016/j.neuropharm.2008.05.002. Epub 2008 May 9.

12.

GABAA receptor alpha5 subunits contribute to GABAA,slow synaptic inhibition in mouse hippocampus.

Zarnowska ED, Keist R, Rudolph U, Pearce RA.

J Neurophysiol. 2009 Mar;101(3):1179-91. doi: 10.1152/jn.91203.2008. Epub 2008 Dec 10.

13.

Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands.

Fradley RL, Guscott MR, Bull S, Hallett DJ, Goodacre SC, Wafford KA, Garrett EM, Newman RJ, O'Meara GF, Whiting PJ, Rosahl TW, Dawson GR, Reynolds DS, Atack JR.

J Psychopharmacol. 2007 Jun;21(4):384-91. Epub 2006 Nov 8.

PMID:
17092983
14.
15.

A novel α5GABA(A)R-positive allosteric modulator reverses hyperactivation of the dopamine system in the MAM model of schizophrenia.

Gill KM, Lodge DJ, Cook JM, Aras S, Grace AA.

Neuropsychopharmacology. 2011 Aug;36(9):1903-11. doi: 10.1038/npp.2011.76. Epub 2011 May 11.

16.

The role of α1 and α5 subunit-containing GABAA receptors in motor impairment induced by benzodiazepines in rats.

Milić M, Divljaković J, Rallapalli S, van Linn ML, Timić T, Cook JM, Savić MM.

Behav Pharmacol. 2012 Apr;23(2):191-7. doi: 10.1097/FBP.0b013e3283512c85.

17.

The alpha5(H105R) mutation impairs alpha5 selective binding properties by altered positioning of the alpha5 subunit in GABAA receptors containing two distinct types of alpha subunits.

Balic E, Rudolph U, Fritschy JM, Mohler H, Benke D.

J Neurochem. 2009 Jul;110(1):244-54. doi: 10.1111/j.1471-4159.2009.06119.x. Epub 2009 Apr 27.

18.

Are GABAA receptors containing alpha5 subunits contributing to the sedative properties of benzodiazepine site agonists?

Savić MM, Huang S, Furtmüller R, Clayton T, Huck S, Obradović DI, Ugresić ND, Sieghart W, Bokonjić DR, Cook JM.

Neuropsychopharmacology. 2008 Jan;33(2):332-9. Epub 2007 Mar 28.

19.
20.

PWZ-029, a compound with moderate inverse agonist functional selectivity at GABA(A) receptors containing alpha5 subunits, improves passive, but not active, avoidance learning in rats.

Savić MM, Clayton T, Furtmüller R, Gavrilović I, Samardzić J, Savić S, Huck S, Sieghart W, Cook JM.

Brain Res. 2008 May 7;1208:150-9. doi: 10.1016/j.brainres.2008.02.020. Epub 2008 Feb 19.

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