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Islet amyloid: from fundamental biophysics to mechanisms of cytotoxicity.

Cao P, Marek P, Noor H, Patsalo V, Tu LH, Wang H, Abedini A, Raleigh DP.

FEBS Lett. 2013 Apr 17;587(8):1106-18. doi: 10.1016/j.febslet.2013.01.046. Epub 2013 Feb 1. Review.


Aggregation of islet amyloid polypeptide: from physical chemistry to cell biology.

Cao P, Abedini A, Raleigh DP.

Curr Opin Struct Biol. 2013 Feb;23(1):82-9. doi: 10.1016/ Epub 2012 Dec 22. Review.


General amyloid inhibitors? A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers.

Wang H, Raleigh DP.

PLoS One. 2014 Sep 26;9(9):e104023. doi: 10.1371/journal.pone.0104023. eCollection 2014.


Islet amyloid polypeptide: a review of its biology and potential roles in the pathogenesis of diabetes mellitus.

O'Brien TD, Butler PC, Westermark P, Johnson KH.

Vet Pathol. 1993 Jul;30(4):317-32. Review.


Mutational analysis of the ability of resveratrol to inhibit amyloid formation by islet amyloid polypeptide: critical evaluation of the importance of aromatic-inhibitor and histidine-inhibitor interactions.

Tu LH, Young LM, Wong AG, Ashcroft AE, Radford SE, Raleigh DP.

Biochemistry. 2015 Jan 27;54(3):666-76. doi: 10.1021/bi501016r. Epub 2015 Jan 15.


Islet amyloid and type 2 diabetes: from molecular misfolding to islet pathophysiology.

Jaikaran ET, Clark A.

Biochim Biophys Acta. 2001 Nov 29;1537(3):179-203. Review.


Mechanisms of islet amyloidosis toxicity in type 2 diabetes.

Abedini A, Schmidt AM.

FEBS Lett. 2013 Apr 17;587(8):1119-27. doi: 10.1016/j.febslet.2013.01.017. Epub 2013 Jan 18. Review.


Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process.

Wiltzius JJ, Sievers SA, Sawaya MR, Eisenberg D.

Protein Sci. 2009 Jul;18(7):1521-30. doi: 10.1002/pro.145.


Formation of islet amyloid fibrils in beta-secretory granules of transgenic mice expressing human islet amyloid polypeptide/amylin.

Yagui K, Yamaguchi T, Kanatsuka A, Shimada F, Huang CI, Tokuyama Y, Ohsawa H, Yamamura K, Miyazaki J, Mikata A, et al.

Eur J Endocrinol. 1995 Apr;132(4):487-96.


Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin).

Wiltzius JJ, Sievers SA, Sawaya MR, Cascio D, Popov D, Riekel C, Eisenberg D.

Protein Sci. 2008 Sep;17(9):1467-74. doi: 10.1110/ps.036509.108. Epub 2008 Jun 12.


Islet Amyloid Polypeptide: Structure, Function, and Pathophysiology.

Akter R, Cao P, Noor H, Ridgway Z, Tu LH, Wang H, Wong AG, Zhang X, Abedini A, Schmidt AM, Raleigh DP.

J Diabetes Res. 2016;2016:2798269. doi: 10.1155/2016/2798269. Epub 2015 Nov 15. Review.


Identification of Human Islet Amyloid Polypeptide as a BACE2 Substrate.

Rulifson IC, Cao P, Miao L, Kopecky D, Huang L, White RD, Samayoa K, Gardner J, Wu X, Chen K, Tsuruda T, Homann O, Baribault H, Yamane H, Carlson T, Wiltzius J, Li Y.

PLoS One. 2016 Feb 3;11(2):e0147254. doi: 10.1371/journal.pone.0147254. eCollection 2016.


Defining the molecular basis of amyloid inhibitors: human islet amyloid polypeptide-insulin interactions.

Susa AC, Wu C, Bernstein SL, Dupuis NF, Wang H, Raleigh DP, Shea JE, Bowers MT.

J Am Chem Soc. 2014 Sep 17;136(37):12912-9. doi: 10.1021/ja504031d. Epub 2014 Sep 4.


Mutational analysis of preamyloid intermediates: the role of his-tyr interactions in islet amyloid formation.

Tu LH, Serrano AL, Zanni MT, Raleigh DP.

Biophys J. 2014 Apr 1;106(7):1520-7. doi: 10.1016/j.bpj.2013.12.052.


Ferret islet amyloid polypeptide (IAPP): characterization of in vitro and in vivo amyloidogenicity.

Paulsson JF, Benoit-Biancamano MO, Schäffer L, Dahl K.

Amyloid. 2011 Dec;18(4):222-8. doi: 10.3109/13506129.2011.627956. Epub 2011 Nov 2.


Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.

Westermark P, Andersson A, Westermark GT.

Physiol Rev. 2011 Jul;91(3):795-826. doi: 10.1152/physrev.00042.2009. Review.


Interaction of membrane-bound islet amyloid polypeptide with soluble and crystalline insulin.

Knight JD, Williamson JA, Miranker AD.

Protein Sci. 2008 Oct;17(10):1850-6. doi: 10.1110/ps.036350.108. Epub 2008 Sep 2.


Selection for nonamyloidogenic mutants of islet amyloid polypeptide (IAPP) identifies an extended region for amyloidogenicity.

Fox A, Snollaerts T, Errecart Casanova C, Calciano A, Nogaj LA, Moffet DA.

Biochemistry. 2010 Sep 14;49(36):7783-9. doi: 10.1021/bi100337p.


Membrane disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective.

Brender JR, Salamekh S, Ramamoorthy A.

Acc Chem Res. 2012 Mar 20;45(3):454-62. doi: 10.1021/ar200189b. Epub 2011 Sep 25.

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