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Items: 1 to 20 of 95


A GEF-to-phospholipase molecular switch caused by phosphatidic acid, Rac and JAK tyrosine kinase that explains leukocyte cell migration.

Mahankali M, Henkels KM, Gomez-Cambronero J.

J Cell Sci. 2013 Mar 15;126(Pt 6):1416-28. doi: 10.1242/jcs.117960. Epub 2013 Feb 1.


Phospholipase D2 (PLD2) is a guanine nucleotide exchange factor (GEF) for the GTPase Rac2.

Mahankali M, Peng HJ, Henkels KM, Dinauer MC, Gomez-Cambronero J.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19617-22. doi: 10.1073/pnas.1114692108. Epub 2011 Nov 21.


PLD Protein-Protein Interactions With Signaling Molecules and Modulation by PA.

Gomez-Cambronero J, Morris AJ, Henkels KM.

Methods Enzymol. 2017;583:327-357. doi: 10.1016/bs.mie.2016.09.042. Epub 2016 Nov 11.


The exquisite regulation of PLD2 by a wealth of interacting proteins: S6K, Grb2, Sos, WASp and Rac2 (and a surprise discovery: PLD2 is a GEF).

Gomez-Cambronero J.

Cell Signal. 2011 Dec;23(12):1885-95. doi: 10.1016/j.cellsig.2011.06.017. Epub 2011 Jun 29. Review.


Identification of the catalytic site of phospholipase D2 (PLD2) newly described guanine nucleotide exchange factor activity.

Mahankali M, Henkels KM, Alter G, Gomez-Cambronero J.

J Biol Chem. 2012 Nov 30;287(49):41417-31. doi: 10.1074/jbc.M112.383596. Epub 2012 Oct 3.


Increased cell growth due to a new lipase-GEF (Phospholipase D2) fastly acting on Ras.

Henkels KM, Mahankali M, Gomez-Cambronero J.

Cell Signal. 2013 Jan;25(1):198-205. doi: 10.1016/j.cellsig.2012.08.010. Epub 2012 Aug 31.


A comprehensive model that explains the regulation of phospholipase D2 activity by phosphorylation-dephosphorylation.

Henkels KM, Peng HJ, Frondorf K, Gomez-Cambronero J.

Mol Cell Biol. 2010 May;30(9):2251-63. doi: 10.1128/MCB.01239-09. Epub 2010 Feb 22.


Cloning of PLD2 from baculovirus for studies in inflammatory responses.

Gomez-Cambronero J, Henkels KM.

Methods Mol Biol. 2012;861:201-25. doi: 10.1007/978-1-61779-600-5_13.


The dual effect of Rac2 on phospholipase D2 regulation that explains both the onset and termination of chemotaxis.

Peng HJ, Henkels KM, Mahankali M, Marchal C, Bubulya P, Dinauer MC, Gomez-Cambronero J.

Mol Cell Biol. 2011 Jun;31(11):2227-40. doi: 10.1128/MCB.01348-10. Epub 2011 Mar 28.


Cell invasion of highly metastatic MTLn3 cancer cells is dependent on phospholipase D2 (PLD2) and Janus kinase 3 (JAK3).

Henkels KM, Farkaly T, Mahankali M, Segall JE, Gomez-Cambronero J.

J Mol Biol. 2011 May 20;408(5):850-62. doi: 10.1016/j.jmb.2011.03.017. Epub 2011 Mar 22.


Mechanism of enzymatic reaction and protein-protein interactions of PLD from a 3D structural model.

Mahankali M, Alter G, Gomez-Cambronero J.

Cell Signal. 2015 Jan;27(1):69-81. doi: 10.1016/j.cellsig.2014.09.008. Epub 2014 Oct 12.


Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF.

Gomez-Cambronero J.

Small GTPases. 2012 Oct-Dec;3(4):202-8. doi: 10.4161/sgtp.20887. Epub 2012 Aug 3.


Phospholipase D2-derived phosphatidic acid binds to and activates ribosomal p70 S6 kinase independently of mTOR.

Lehman N, Ledford B, Di Fulvio M, Frondorf K, McPhail LC, Gomez-Cambronero J.

FASEB J. 2007 Apr;21(4):1075-87. Epub 2007 Jan 22.


The molecular basis of phospholipase D2-induced chemotaxis: elucidation of differential pathways in macrophages and fibroblasts.

Knapek K, Frondorf K, Post J, Short S, Cox D, Gomez-Cambronero J.

Mol Cell Biol. 2010 Sep;30(18):4492-506. doi: 10.1128/MCB.00229-10. Epub 2010 Jul 20.


Biochemical and cellular implications of a dual lipase-GEF function of phospholipase D2 (PLD2).

Gomez-Cambronero J.

J Leukoc Biol. 2012 Sep;92(3):461-7. doi: 10.1189/jlb.0212073. Epub 2012 Jul 2. Review.


Phospholipase D in cell signaling: from a myriad of cell functions to cancer growth and metastasis.

Gomez-Cambronero J.

J Biol Chem. 2014 Aug 15;289(33):22557-66. doi: 10.1074/jbc.R114.574152. Epub 2014 Jul 2. Review.


New concepts in phospholipase D signaling in inflammation and cancer.

Gomez-Cambronero J.

ScientificWorldJournal. 2010 Jul 7;10:1356-69. doi: 10.1100/tsw.2010.116. Review.


Serum deprivation confers the MDA-MB-231 breast cancer line with an EGFR/JAK3/PLD2 system that maximizes cancer cell invasion.

Ye Q, Kantonen S, Gomez-Cambronero J.

J Mol Biol. 2013 Feb 22;425(4):755-66. doi: 10.1016/j.jmb.2012.11.035. Epub 2012 Dec 10.


Phosphatidic Acid Increases Epidermal Growth Factor Receptor Expression by Stabilizing mRNA Decay and by Inhibiting Lysosomal and Proteasomal Degradation of the Internalized Receptor.

Hatton N, Lintz E, Mahankali M, Henkels KM, Gomez-Cambronero J.

Mol Cell Biol. 2015 Sep;35(18):3131-44. doi: 10.1128/MCB.00286-15. Epub 2015 Jun 29.


Evidence for two CRIB domains in phospholipase D2 (PLD2) that the enzyme uses to specifically bind to the small GTPase Rac2.

Peng HJ, Henkels KM, Mahankali M, Dinauer MC, Gomez-Cambronero J.

J Biol Chem. 2011 May 6;286(18):16308-20. doi: 10.1074/jbc.M110.206672. Epub 2011 Mar 4.

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