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Items: 1 to 20 of 159

1.

3D organotypic cultures of human HepaRG cells: a tool for in vitro toxicity studies.

Gunness P, Mueller D, Shevchenko V, Heinzle E, Ingelman-Sundberg M, Noor F.

Toxicol Sci. 2013 May;133(1):67-78. doi: 10.1093/toxsci/kft021. Epub 2013 Feb 1.

PMID:
23377618
2.

3D organotypic HepaRG cultures as in vitro model for acute and repeated dose toxicity studies.

Mueller D, Krämer L, Hoffmann E, Klein S, Noor F.

Toxicol In Vitro. 2014 Feb;28(1):104-12. doi: 10.1016/j.tiv.2013.06.024. Epub 2013 Jul 9.

PMID:
23850736
3.

HepaRG microencapsulated spheroids in DMSO-free culture: novel culturing approaches for enhanced xenobiotic and biosynthetic metabolism.

Rebelo SP, Costa R, Estrada M, Shevchenko V, Brito C, Alves PM.

Arch Toxicol. 2015 Aug;89(8):1347-58. doi: 10.1007/s00204-014-1320-9. Epub 2014 Aug 9.

PMID:
25107451
4.

Hepatic 3D cultures but not 2D cultures preserve specific transporter activity for acetaminophen-induced hepatotoxicity.

Schyschka L, Sánchez JJ, Wang Z, Burkhardt B, Müller-Vieira U, Zeilinger K, Bachmann A, Nadalin S, Damm G, Nussler AK.

Arch Toxicol. 2013 Aug;87(8):1581-93. doi: 10.1007/s00204-013-1080-y. Epub 2013 Jun 1.

PMID:
23728527
5.

HepaRG culture in tethered spheroids as an in vitro three-dimensional model for drug safety screening.

Wang Z, Luo X, Anene-Nzelu C, Yu Y, Hong X, Singh NH, Xia L, Liu S, Yu H.

J Appl Toxicol. 2015 Aug;35(8):909-17. doi: 10.1002/jat.3090. Epub 2014 Dec 15.

PMID:
25512232
6.

3D spheroid cultures improve the metabolic gene expression profiles of HepaRG cells.

Takahashi Y, Hori Y, Yamamoto T, Urashima T, Ohara Y, Tanaka H.

Biosci Rep. 2015 May 7;35(3). pii: e00208. doi: 10.1042/BSR20150034.

7.

A long-term three dimensional liver co-culture system for improved prediction of clinically relevant drug-induced hepatotoxicity.

Kostadinova R, Boess F, Applegate D, Suter L, Weiser T, Singer T, Naughton B, Roth A.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):1-16. doi: 10.1016/j.taap.2013.01.012. Epub 2013 Jan 23.

PMID:
23352505
8.

A 3D in vitro model of differentiated HepG2 cell spheroids with improved liver-like properties for repeated dose high-throughput toxicity studies.

Ramaiahgari SC, den Braver MW, Herpers B, Terpstra V, Commandeur JN, van de Water B, Price LS.

Arch Toxicol. 2014 May;88(5):1083-95. doi: 10.1007/s00204-014-1215-9. Epub 2014 Mar 6.

PMID:
24599296
9.

Three-dimensional HepaRG model as an attractive tool for toxicity testing.

Leite SB, Wilk-Zasadna I, Zaldivar JM, Airola E, Reis-Fernandes MA, Mennecozzi M, Guguen-Guillouzo C, Chesne C, Guillou C, Alves PM, Coecke S.

Toxicol Sci. 2012 Nov;130(1):106-16. doi: 10.1093/toxsci/kfs232. Epub 2012 Jul 27.

PMID:
22843569
10.

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro.

Lübberstedt M, Müller-Vieira U, Mayer M, Biemel KM, Knöspel F, Knobeloch D, Nüssler AK, Gerlach JC, Zeilinger K.

J Pharmacol Toxicol Methods. 2011 Jan-Feb;63(1):59-68. doi: 10.1016/j.vascn.2010.04.013. Epub 2010 May 9.

PMID:
20460162
11.

Fluorometric assessment of acetaminophen-induced toxicity in rat hepatocyte spheroids seeded on micro-space cell culture plates.

Sanoh S, Santoh M, Takagi M, Kanayama T, Sugihara K, Kotake Y, Ejiri Y, Horie T, Kitamura S, Ohta S.

Toxicol In Vitro. 2014 Sep;28(6):1176-82. doi: 10.1016/j.tiv.2014.05.007. Epub 2014 May 28.

PMID:
24878114
12.

Human Hepatic HepaRG Cells Maintain an Organotypic Phenotype with High Intrinsic CYP450 Activity/Metabolism and Significantly Outperform Standard HepG2/C3A Cells for Pharmaceutical and Therapeutic Applications.

Nelson LJ, Morgan K, Treskes P, Samuel K, Henderson CJ, LeBled C, Homer N, Grant MH, Hayes PC, Plevris JN.

Basic Clin Pharmacol Toxicol. 2017 Jan;120(1):30-37. doi: 10.1111/bcpt.12631. Epub 2016 Jul 15.

13.

Rat primary hepatocytes show enhanced performance and sensitivity to acetaminophen during three-dimensional culture on a polystyrene scaffold designed for routine use.

Schutte M, Fox B, Baradez MO, Devonshire A, Minguez J, Bokhari M, Przyborski S, Marshall D.

Assay Drug Dev Technol. 2011 Oct;9(5):475-86. doi: 10.1089/adt.2011.0371. Epub 2011 Jun 15.

PMID:
21675871
14.

Accessing 3D microtissue metabolism: Lactate and oxygen monitoring in hepatocyte spheroids.

Weltin A, Hammer S, Noor F, Kaminski Y, Kieninger J, Urban GA.

Biosens Bioelectron. 2017 Jan 15;87:941-948. doi: 10.1016/j.bios.2016.07.094. Epub 2016 Jul 28.

PMID:
27665516
15.

Toxicogenomics-based prediction of acetaminophen-induced liver injury using human hepatic cell systems.

Rodrigues RM, Heymans A, De Boe V, Sachinidis A, Chaudhari U, Govaere O, Roskams T, Vanhaecke T, Rogiers V, De Kock J.

Toxicol Lett. 2016 Jan 5;240(1):50-9. doi: 10.1016/j.toxlet.2015.10.014. Epub 2015 Oct 20.

PMID:
26497421
16.

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes.

Ware BR, Berger DR, Khetani SR.

Toxicol Sci. 2015 Jun;145(2):252-62. doi: 10.1093/toxsci/kfv048. Epub 2015 Feb 24.

PMID:
25716675
17.

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.

Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW.

Drug Metab Dispos. 2003 Apr;31(4):439-46.

18.

Self-assembled 3D spheroids and hollow-fibre bioreactors improve MSC-derived hepatocyte-like cell maturation in vitro.

Cipriano M, Freyer N, Knöspel F, Oliveira NG, Barcia R, Cruz PE, Cruz H, Castro M, Santos JM, Zeilinger K, Miranda JP.

Arch Toxicol. 2017 Apr;91(4):1815-1832. doi: 10.1007/s00204-016-1838-0. Epub 2016 Sep 2.

PMID:
27590069
19.

Evaluation of drug toxicity with hepatocytes cultured in a micro-space cell culture system.

Nakamura K, Mizutani R, Sanbe A, Enosawa S, Kasahara M, Nakagawa A, Ejiri Y, Murayama N, Miyamoto Y, Torii T, Kusakawa S, Yamauchi J, Fukuda M, Yamazaki H, Tanoue A.

J Biosci Bioeng. 2011 Jan;111(1):78-84. doi: 10.1016/j.jbiosc.2010.08.008. Epub 2010 Sep 15.

PMID:
20837398
20.

Human HepaRG Cells can be Cultured in Hanging-drop Plates for Cytochrome P450 Induction and Function Assays.

Murayama N, Usui T, Slawny N, Chesné C, Yamazaki H.

Drug Metab Lett. 2015;9(1):3-7.

PMID:
25600204

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