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Neuroinflammation in overnutrition-induced diseases.

Cai D.

Vitam Horm. 2013;91:195-218. doi: 10.1016/B978-0-12-407766-9.00008-0. Review.


Hypothalamic IKKbeta/NF-kappaB and ER stress link overnutrition to energy imbalance and obesity.

Zhang X, Zhang G, Zhang H, Karin M, Bai H, Cai D.

Cell. 2008 Oct 3;135(1):61-73. doi: 10.1016/j.cell.2008.07.043.


Neuroinflammation and neurodegeneration in overnutrition-induced diseases.

Cai D.

Trends Endocrinol Metab. 2013 Jan;24(1):40-7. doi: 10.1016/j.tem.2012.11.003. Epub 2012 Dec 20. Review.


Neuroinflammatory basis of metabolic syndrome.

Purkayastha S, Cai D.

Mol Metab. 2013 Oct 5;2(4):356-63. doi: 10.1016/j.molmet.2013.09.005. Review.


NFkappaB-mediated metabolic inflammation in peripheral tissues versus central nervous system.

Cai D.

Cell Cycle. 2009 Aug 15;8(16):2542-8. Epub 2009 Aug 29. Review.


Central inhibition of IKKβ/NF-κB signaling attenuates high-fat diet-induced obesity and glucose intolerance.

Benzler J, Ganjam GK, Pretz D, Oelkrug R, Koch CE, Legler K, Stöhr S, Culmsee C, Williams LM, Tups A.

Diabetes. 2015 Jun;64(6):2015-27. doi: 10.2337/db14-0093. Epub 2015 Jan 27.


Inflammatory cause of metabolic syndrome via brain stress and NF-κB.

Cai D, Liu T.

Aging (Albany NY). 2012 Feb;4(2):98-115. Review.


AMAP1 as a negative-feedback regulator of nuclear factor-κB under inflammatory conditions.

Tien DN, Kishihata M, Yoshikawa A, Hashimoto A, Sabe H, Nishi E, Kamei K, Arai H, Kita T, Kimura T, Yokode M, Ashida N.

Sci Rep. 2014 May 28;4:5094. doi: 10.1038/srep05094.


Constitutive intestinal NF-κB does not trigger destructive inflammation unless accompanied by MAPK activation.

Guma M, Stepniak D, Shaked H, Spehlmann ME, Shenouda S, Cheroutre H, Vicente-Suarez I, Eckmann L, Kagnoff MF, Karin M.

J Exp Med. 2011 Aug 29;208(9):1889-900. doi: 10.1084/jem.20110242. Epub 2011 Aug 8. Erratum in: J Exp Med. 2012 Sep 24;209(10):1901.


The nuclear factor NF-kappaB pathway in inflammation.

Lawrence T.

Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651. doi: 10.1101/cshperspect.a001651. Epub 2009 Oct 7. Review.


Regulation and function of IKK and IKK-related kinases.

Häcker H, Karin M.

Sci STKE. 2006 Oct 17;2006(357):re13. Review.


IKK-related genetic diseases: probing NF-κB functions in humans and other matters.

Senegas A, Gautheron J, Maurin AG, Courtois G.

Cell Mol Life Sci. 2015 Apr;72(7):1275-87. doi: 10.1007/s00018-014-1793-y. Epub 2014 Nov 29. Review. Erratum in: Cell Mol Life Sci. 2015 Apr;72(7):1289.


Inhibition of the IKK/NF-κB pathway by AAV gene transfer improves muscle regeneration in older mdx mice.

Tang Y, Reay DP, Salay MN, Mi MY, Clemens PR, Guttridge DC, Robbins PD, Huard J, Wang B.

Gene Ther. 2010 Dec;17(12):1476-83. doi: 10.1038/gt.2010.110. Epub 2010 Aug 19.


Effects of brain IKKβ gene silencing by small interfering RNA on P-glycoprotein expression and brain damage in the rat kainic acid-induced seizure model.

Yu N, Liu H, Zhang YF, Su LY, Liu XH, Li LC, Hao JB, Huang XJ, Di Q.

CNS Neurol Disord Drug Targets. 2014;13(4):661-72.


Interferon regulatory factor 3 constrains IKKβ/NF-κB signaling to alleviate hepatic steatosis and insulin resistance.

Wang XA, Zhang R, She ZG, Zhang XF, Jiang DS, Wang T, Gao L, Deng W, Zhang SM, Zhu LH, Guo S, Chen K, Zhang XD, Liu DP, Li H.

Hepatology. 2014 Mar;59(3):870-85. doi: 10.1002/hep.26751. Epub 2014 Jan 30.


Inflammatory NF-kappaB activation promotes hepatic apolipoprotein B100 secretion: evidence for a link between hepatic inflammation and lipoprotein production.

Tsai J, Zhang R, Qiu W, Su Q, Naples M, Adeli K.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1287-98. doi: 10.1152/ajpgi.90540.2008. Epub 2009 Apr 2.


IkappaB kinase beta (IKKbeta/IKK2/IKBKB)--a key molecule in signaling to the transcription factor NF-kappaB.

Schmid JA, Birbach A.

Cytokine Growth Factor Rev. 2008 Apr;19(2):157-65. doi: 10.1016/j.cytogfr.2008.01.006. Epub 2008 Mar 4. Review.


Pathogenic role of NF-kappaB activation in tubulointerstitial inflammatory lesions in human lupus nephritis.

Zheng L, Sinniah R, Hsu SI.

J Histochem Cytochem. 2008 May;56(5):517-29. doi: 10.1369/jhc.7A7368.2008. Epub 2008 Feb 18.


IKKbeta inhibition protects against bone and cartilage destruction in a rat model of rheumatoid arthritis.

Schopf L, Savinainen A, Anderson K, Kujawa J, DuPont M, Silva M, Siebert E, Chandra S, Morgan J, Gangurde P, Wen D, Lane J, Xu Y, Hepperle M, Harriman G, Ocain T, Jaffee B.

Arthritis Rheum. 2006 Oct;54(10):3163-73.

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