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Items: 1 to 20 of 70

1.

Ser9 phosphorylation causes cytoplasmic detention of I2PP2A/SET in Alzheimer disease.

Yu G, Yan T, Feng Y, Liu X, Xia Y, Luo H, Wang JZ, Wang X.

Neurobiol Aging. 2013 Jul;34(7):1748-58. doi: 10.1016/j.neurobiolaging.2012.12.025. Epub 2013 Jan 29.

PMID:
23374587
2.

Cytoplasmic retention of protein phosphatase 2A inhibitor 2 (I2PP2A) induces Alzheimer-like abnormal hyperphosphorylation of Tau.

Arif M, Wei J, Zhang Q, Liu F, Basurto-Islas G, Grundke-Iqbal I, Iqbal K.

J Biol Chem. 2014 Oct 3;289(40):27677-91. doi: 10.1074/jbc.M114.565358. Epub 2014 Aug 15.

3.

SET translocation is associated with increase in caspase cleaved amyloid precursor protein in CA1 of Alzheimer and Down syndrome patients.

Facchinetti P, Dorard E, Contremoulins V, Gaillard MC, Déglon N, Sazdovitch V, Guihenneuc-Jouyaux C, Brouillet E, Duyckaerts C, Allinquant B.

Neurobiol Aging. 2014 May;35(5):958-68. doi: 10.1016/j.neurobiolaging.2013.08.039. Epub 2013 Nov 5.

PMID:
24262202
4.

Involvement of I2PP2A in the abnormal hyperphosphorylation of tau and its reversal by Memantine.

Chohan MO, Khatoon S, Iqbal IG, Iqbal K.

FEBS Lett. 2006 Jul 10;580(16):3973-9. Epub 2006 Jun 19.

5.

Cytoplasmic SET induces tau hyperphosphorylation through a decrease of methylated phosphatase 2A.

Chasseigneaux S, Clamagirand C, Huguet L, Gorisse-Hussonnois L, Rose C, Allinquant B.

BMC Neurosci. 2014 Jun 30;15:82. doi: 10.1186/1471-2202-15-82.

7.

Alzheimer disease and amyotrophic lateral sclerosis: an etiopathogenic connection.

Wang X, Blanchard J, Grundke-Iqbal I, Wegiel J, Deng HX, Siddique T, Iqbal K.

Acta Neuropathol. 2014 Feb;127(2):243-56. doi: 10.1007/s00401-013-1175-9. Epub 2013 Oct 18.

8.

Activation of asparaginyl endopeptidase leads to Tau hyperphosphorylation in Alzheimer disease.

Basurto-Islas G, Grundke-Iqbal I, Tung YC, Liu F, Iqbal K.

J Biol Chem. 2013 Jun 14;288(24):17495-507. doi: 10.1074/jbc.M112.446070. Epub 2013 May 2.

9.

Phosphorylation of SET protein at Ser171 by protein kinase D2 diminishes its inhibitory effect on protein phosphatase 2A.

Irie A, Harada K, Araki N, Nishimura Y.

PLoS One. 2012;7(12):e51242. doi: 10.1371/journal.pone.0051242. Epub 2012 Dec 14.

10.

Tau hyperphosphorylation correlates with reduced methylation of protein phosphatase 2A.

Zhou XW, Gustafsson JA, Tanila H, Bjorkdahl C, Liu R, Winblad B, Pei JJ.

Neurobiol Dis. 2008 Sep;31(3):386-94. doi: 10.1016/j.nbd.2008.05.013. Epub 2008 Jul 23.

PMID:
18586097
11.

SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain.

Madeira A, Pommet JM, Prochiantz A, Allinquant B.

FASEB J. 2005 Nov;19(13):1905-7. Epub 2005 Sep 14.

PMID:
16162853
12.

Mechanism of inhibition of PP2A activity and abnormal hyperphosphorylation of tau by I2(PP2A)/SET.

Arnaud L, Chen S, Liu F, Li B, Khatoon S, Grundke-Iqbal I, Iqbal K.

FEBS Lett. 2011 Sep 2;585(17):2653-9. doi: 10.1016/j.febslet.2011.07.020. Epub 2011 Jul 28.

13.

Cytoplasmic targeting of the proto-oncogene SET promotes cell spreading and migration.

Lam BD, Anthony EC, Hordijk PL.

FEBS Lett. 2013 Jan 16;587(2):111-9. doi: 10.1016/j.febslet.2012.11.013. Epub 2012 Nov 26.

14.

Zinc induces protein phosphatase 2A inactivation and tau hyperphosphorylation through Src dependent PP2A (tyrosine 307) phosphorylation.

Xiong Y, Jing XP, Zhou XW, Wang XL, Yang Y, Sun XY, Qiu M, Cao FY, Lu YM, Liu R, Wang JZ.

Neurobiol Aging. 2013 Mar;34(3):745-56. doi: 10.1016/j.neurobiolaging.2012.07.003. Epub 2012 Aug 11.

PMID:
22892311
15.

Analysis of nucleo-cytoplasmic shuttling of the proto-oncogene SET/I2PP2A.

Lam BD, Anthony EC, Hordijk PL.

Cytometry A. 2012 Jan;81(1):81-9. doi: 10.1002/cyto.a.21153. Epub 2011 Oct 11.

17.

CK2 Phosphorylating I2PP2A/SET Mediates Tau Pathology and Cognitive Impairment.

Zhang Q, Xia Y, Wang Y, Shentu Y, Zeng K, Mahaman YAR, Huang F, Wu M, Ke D, Wang Q, Zhang B, Liu R, Wang JZ, Ye K, Wang X.

Front Mol Neurosci. 2018 Apr 30;11:146. doi: 10.3389/fnmol.2018.00146. eCollection 2018.

19.

Biguanide metformin acts on tau phosphorylation via mTOR/protein phosphatase 2A (PP2A) signaling.

Kickstein E, Krauss S, Thornhill P, Rutschow D, Zeller R, Sharkey J, Williamson R, Fuchs M, Köhler A, Glossmann H, Schneider R, Sutherland C, Schweiger S.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21830-5. doi: 10.1073/pnas.0912793107. Epub 2010 Nov 22.

20.

Novel therapeutic strategies for neurodegenerative disease.

Tanimukai H, Kudo T, Tanaka T, Grundke-Iqbal I, Iqbal K, Takeda M.

Psychogeriatrics. 2009 Jun;9(2):103-9. doi: 10.1111/j.1479-8301.2009.00289.x. Review.

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