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Importance of Peptide transporter 2 on the cerebrospinal fluid efflux kinetics of glycylsarcosine characterized by nonlinear mixed effects modeling.

Huh Y, Hynes SM, Smith DE, Feng MR.

Pharm Res. 2013 May;30(5):1423-34. doi: 10.1007/s11095-013-0980-0. Epub 2013 Feb 1.


Distribution of glycylsarcosine and cefadroxil among cerebrospinal fluid, choroid plexus, and brain parenchyma after intracerebroventricular injection is markedly different between wild-type and Pept2 null mice.

Smith DE, Hu Y, Shen H, Nagaraja TN, Fenstermacher JD, Keep RF.

J Cereb Blood Flow Metab. 2011 Jan;31(1):250-61. doi: 10.1038/jcbfm.2010.84. Epub 2010 Jun 23.


Role of PEPT2 in the choroid plexus uptake of glycylsarcosine and 5-aminolevulinic acid: studies in wild-type and null mice.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE.

Pharm Res. 2004 Sep;21(9):1680-5.


Population pharmacokinetic modeling of cefadroxil renal transport in wild-type and Pept2 knockout mice.

Xie Y, Shen H, Hu Y, Feng MR, Smith DE.

Xenobiotica. 2016;46(4):342-9. doi: 10.3109/00498254.2015.1080881. Epub 2015 Sep 15.


Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice.

Shen H, Ocheltree SM, Hu Y, Keep RF, Smith DE.

Drug Metab Dispos. 2007 Jul;35(7):1209-16. Epub 2007 Apr 23.


Role of PEPT2 in glycylsarcosine transport in astrocyte and glioma cultures.

Xiang J, Chiang PP, Hu Y, Smith DE, Keep RF.

Neurosci Lett. 2006 Apr 3;396(3):225-9. Epub 2005 Dec 20.


Targeted disruption of the PEPT2 gene markedly reduces dipeptide uptake in choroid plexus.

Shen H, Smith DE, Keep RF, Xiang J, Brosius FC 3rd.

J Biol Chem. 2003 Feb 14;278(7):4786-91. Epub 2002 Dec 6.


Influence of genetic knockout of Pept2 on the in vivo disposition of endogenous and exogenous carnosine in wild-type and Pept2 null mice.

Kamal MA, Jiang H, Hu Y, Keep RF, Smith DE.

Am J Physiol Regul Integr Comp Physiol. 2009 Apr;296(4):R986-91. doi: 10.1152/ajpregu.90744.2008. Epub 2009 Feb 18.


Functional evidence for presence of PEPT2 in rat choroid plexus: studies with glycylsarcosine.

Teuscher NS, Novotny A, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2000 Aug;294(2):494-9.


Effect of dose escalation on the in vivo oral absorption and disposition of glycylsarcosine in wild-type and Pept1 knockout mice.

Jappar D, Hu Y, Smith DE.

Drug Metab Dispos. 2011 Dec;39(12):2250-7. doi: 10.1124/dmd.111.041087. Epub 2011 Aug 31.


Divergent developmental expression and function of the proton-coupled oligopeptide transporters PepT2 and PhT1 in regional brain slices of mouse and rat.

Hu Y, Xie Y, Keep RF, Smith DE.

J Neurochem. 2014 Jun;129(6):955-65. doi: 10.1111/jnc.12687. Epub 2014 Mar 20.


Mechanisms of cefadroxil uptake in the choroid plexus: studies in wild-type and PEPT2 knockout mice.

Ocheltree SM, Shen H, Hu Y, Xiang J, Keep RF, Smith DE.

J Pharmacol Exp Ther. 2004 Feb;308(2):462-7. Epub 2003 Nov 4.


PEPT2 (Slc15a2)-mediated unidirectional transport of cefadroxil from cerebrospinal fluid into choroid plexus.

Shen H, Keep RF, Hu Y, Smith DE.

J Pharmacol Exp Ther. 2005 Dec;315(3):1101-8. Epub 2005 Aug 17.


Targeted disruption of the peptide transporter Pept2 gene in mice defines its physiological role in the kidney.

Rubio-Aliaga I, Frey I, Boll M, Groneberg DA, Eichinger HM, Balling R, Daniel H.

Mol Cell Biol. 2003 May;23(9):3247-52.

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