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Chronic ingestion of ethanol induces hepatocellular carcinoma in mice without additional hepatic insult.

Tsuchishima M, George J, Shiroeda H, Arisawa T, Takegami T, Tsutsumi M.

Dig Dis Sci. 2013 Jul;58(7):1923-33. doi: 10.1007/s10620-013-2574-4. Epub 2013 Jan 31.


Chronic ethanol feeding accelerates hepatocellular carcinoma progression in a sex-dependent manner in a mouse model of hepatocarcinogenesis.

Brandon-Warner E, Walling TL, Schrum LW, McKillop IH.

Alcohol Clin Exp Res. 2012 Apr;36(4):641-53. doi: 10.1111/j.1530-0277.2011.01660.x. Epub 2011 Oct 21.


Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells.

Kim BJ, Hood BL, Aragon RA, Hardwick JP, Conrads TP, Veenstra TD, Song BJ.

Proteomics. 2006 Feb;6(4):1250-60.


The effect of alcohol on Sirt1 expression and function in animal and human models of hepatocellular carcinoma (HCC).

Thompson KJ, Humphries JR, Niemeyer DJ, Sindram D, McKillop IH.

Adv Exp Med Biol. 2015;815:361-73. doi: 10.1007/978-3-319-09614-8_21.


NTP technical report on the toxicology and carcinogenesis studies of Elmiron (Cas No. 37319-17-8) in F344/N rats and B6C3F1 mice (Gavage Studies).

National Toxicology Program, Public Health Services, National Institutes of Health, US Department of Health and Human Services,.

Natl Toxicol Program Tech Rep Ser. 2004 May;(512):7-289.


Alcohol induces liver neoplasia in a novel alcohol-preferring rat model.

Yip-Schneider MT, Doyle CJ, McKillop IH, Wentz SC, Brandon-Warner E, Matos JM, Sandrasegaran K, Saxena R, Hennig ME, Wu H, Waters JA, Klein PJ, Froehlich JC, Schmidt CM.

Alcohol Clin Exp Res. 2011 Dec;35(12):2216-25. doi: 10.1111/j.1530-0277.2011.01568.x. Epub 2011 Jul 25.


Ethanol-TGFalpha-MEK signaling promotes growth of human hepatocellular carcinoma.

Hennig M, Yip-Schneider MT, Klein P, Wentz S, Matos JM, Doyle C, Choi J, Wu H, O'Mara A, Menze A, Noble S, McKillop IH, Schmidt CM.

J Surg Res. 2009 Jun 15;154(2):187-95. doi: 10.1016/j.jss.2008.11.836. Epub 2008 Dec 13.


Alcohol induced hepatic degeneration in a hepatitis C virus core protein transgenic mouse model.

Noh DH, Lee EJ, Kim AY, Lee EM, Min CW, Kang KK, Lee MM, Kim SH, Sung SE, Hwang M, Yu DY, Jeong KS.

Int J Mol Sci. 2014 Mar 7;15(3):4126-41. doi: 10.3390/ijms15034126.


Glycycoumarin ameliorates alcohol-induced hepatotoxicity via activation of Nrf2 and autophagy.

Song X, Yin S, Huo Y, Liang M, Fan L, Ye M, Hu H.

Free Radic Biol Med. 2015 Dec;89:135-46. doi: 10.1016/j.freeradbiomed.2015.07.006. Epub 2015 Jul 11.


The Applicability of a Human Immunohistochemical Panel to Mouse Models of Hepatocellular Neoplasia.

Salleng KJ, Revetta FL, Deane NG, Washington MK.

Comp Med. 2015 Oct;65(5):398-408.


Diet-induced obesity and ethanol impair progression of hepatocellular carcinoma in a mouse mesenteric vein injection model.

Thompson KJ, Swan RZ, Iannitti DA, McKillop IH, Sindram D.

Surg Endosc. 2013 Jan;27(1):246-55. doi: 10.1007/s00464-012-2429-7. Epub 2012 Jul 18.


Obesity, but not ethanol, promotes tumor incidence and progression in a mouse model of hepatocellular carcinoma in vivo.

Thompson KJ, Swan RZ, Walling TL, Iannitti DA, McKillop IH, Sindram D.

Surg Endosc. 2013 Aug;27(8):2782-91. doi: 10.1007/s00464-013-2808-8. Epub 2013 Mar 7.


Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression.

Zhong S, Machida K, Tsukamoto H, Johnson DL.

J Biol Chem. 2011 Jan 28;286(4):2393-401. doi: 10.1074/jbc.M110.192955. Epub 2010 Nov 24.


Dynamics of cytochrome P4502E1 activity in man: induction by ethanol and disappearance during withdrawal phase.

Oneta CM, Lieber CS, Li J, Rüttimann S, Schmid B, Lattmann J, Rosman AS, Seitz HK.

J Hepatol. 2002 Jan;36(1):47-52.


Paracrine activation of hepatic stellate cells in platelet-derived growth factor C transgenic mice: evidence for stromal induction of hepatocellular carcinoma.

Wright JH, Johnson MM, Shimizu-Albergine M, Bauer RL, Hayes BJ, Surapisitchat J, Hudkins KL, Riehle KJ, Johnson SC, Yeh MM, Bammler TK, Beyer RP, Gilbertson DG, Alpers CE, Fausto N, Campbell JS.

Int J Cancer. 2014 Feb 15;134(4):778-88. doi: 10.1002/ijc.28421. Epub 2013 Sep 16.


Silymarin protects against acute ethanol-induced hepatotoxicity in mice.

Song Z, Deaciuc I, Song M, Lee DY, Liu Y, Ji X, McClain C.

Alcohol Clin Exp Res. 2006 Mar;30(3):407-13.


Commentary with regard to the role of alcohol and cofactors in the development of hepatocellular carcinoma.

Jerrells TR.

Alcohol Clin Exp Res. 2012 Apr;36(4):564-5. doi: 10.1111/j.1530-0277.2012.01780.x. Epub 2012 Mar 13.


Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes.

Zhong Q, Shi G, Zhang Y, Levy D, Zhong S.

Gene. 2013 Aug 15;526(1):54-60. doi: 10.1016/j.gene.2013.02.004. Epub 2013 Feb 20.


Metabolic basis of ethanol-induced cytotoxicity in recombinant HepG2 cells: role of nonoxidative metabolism.

Wu H, Cai P, Clemens DL, Jerrells TR, Ansari GA, Kaphalia BS.

Toxicol Appl Pharmacol. 2006 Oct 15;216(2):238-47. Epub 2006 May 19. Erratum in: Toxicol Appl Pharmacol. 2007 Apr 1;220(1):111-2.


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