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Items: 1 to 20 of 104


Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis.

Chen YC, Chan JY, Chiu YL, Liu ST, Lozano G, Wang SL, Ho CL, Huang SM.

Cell Death Differ. 2013 May;20(5):732-43. doi: 10.1038/cdd.2013.1. Epub 2013 Feb 1.


Human rpL3 induces G₁/S arrest or apoptosis by modulating p21 (waf1/cip1) levels in a p53-independent manner.

Russo A, Esposito D, Catillo M, Pietropaolo C, Crescenzi E, Russo G.

Cell Cycle. 2013 Jan 1;12(1):76-87. doi: 10.4161/cc.22963. Epub 2012 Dec 19.


TRIM8 modulates p53 activity to dictate cell cycle arrest.

Caratozzolo MF, Micale L, Turturo MG, Cornacchia S, Fusco C, Marzano F, Augello B, D'Erchia AM, Guerrini L, Pesole G, Sbisà E, Merla G, Tullo A.

Cell Cycle. 2012 Feb 1;11(3):511-23. doi: 10.4161/cc.11.3.19008. Epub 2012 Feb 1.


p53 efficiently suppresses tumor development in the complete absence of its cell-cycle inhibitory and proapoptotic effectors p21, Puma, and Noxa.

Valente LJ, Gray DH, Michalak EM, Pinon-Hofbauer J, Egle A, Scott CL, Janic A, Strasser A.

Cell Rep. 2013 May 30;3(5):1339-45. doi: 10.1016/j.celrep.2013.04.012. Epub 2013 May 9.


The p53-p21WAF1 checkpoint pathway plays a protective role in preventing DNA rereplication induced by abrogation of FOXF1 function.

Lo PK, Lee JS, Sukumar S.

Cell Signal. 2012 Jan;24(1):316-24. doi: 10.1016/j.cellsig.2011.09.017. Epub 2011 Sep 22.


The histone acetyltransferase PCAF regulates p21 transcription through stress-induced acetylation of histone H3.

Love IM, Sekaric P, Shi D, Grossman SR, Androphy EJ.

Cell Cycle. 2012 Jul 1;11(13):2458-66. doi: 10.4161/cc.20864. Epub 2012 Jul 1.


Mdm2 inhibition of p53 induces E2F1 transactivation via p21.

Wunderlich M, Berberich SJ.

Oncogene. 2002 Jun 27;21(28):4414-21.


Endoplasmic reticulum stress sensitizes cells to DNA damage-induced apoptosis through p53-dependent suppression of p21(CDKN1A).

Mlynarczyk C, Fåhraeus R.

Nat Commun. 2014 Oct 8;5:5067. doi: 10.1038/ncomms6067.


Sam68 functions as a transcriptional coactivator of the p53 tumor suppressor.

Li N, Richard S.

Nucleic Acids Res. 2016 Oct 14;44(18):8726-8741. Epub 2016 Jun 30.


Identification of p53-46F as a super p53 with an enhanced ability to induce p53-dependent apoptosis.

Nakamura Y, Futamura M, Kamino H, Yoshida K, Nakamura Y, Arakawa H.

Cancer Sci. 2006 Jul;97(7):633-41.


A single mutant, A276S of p53, turns the switch to apoptosis.

Reaz S, Mossalam M, Okal A, Lim CS.

Mol Pharm. 2013 Apr 1;10(4):1350-9. doi: 10.1021/mp300598k. Epub 2013 Mar 1.


Suppression of centrosome protein TACC3 induces G1 arrest and cell death through activation of p38-p53-p21 stress signaling pathway.

Suhail TV, Singh P, Manna TK.

Eur J Cell Biol. 2015 Feb;94(2):90-100. doi: 10.1016/j.ejcb.2014.12.001. Epub 2015 Jan 5.


Stabilization and reactivation of the p53 tumor suppressor protein in nontumorigenic revertants of HeLa cervical cancer cells.

Athanassiou M, Hu Y, Jing L, Houle B, Zarbl H, Mikheev AM.

Cell Growth Differ. 1999 Nov;10(11):729-37.


E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis.

Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W, Feng Z.

Cell Death Differ. 2014 Nov;21(11):1792-804. doi: 10.1038/cdd.2014.121. Epub 2014 Aug 22.


PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.

Hu F, Gartenhaus RB, Eichberg D, Liu Z, Fang HB, Rapoport AP.

Oncogene. 2010 Oct 7;29(40):5464-74. doi: 10.1038/onc.2010.275. Epub 2010 Jul 12.


Antiproliferative autoantigen CDA1 transcriptionally up-regulates p21(Waf1/Cip1) by activating p53 and MEK/ERK1/2 MAPK pathways.

Tu Y, Wu W, Wu T, Cao Z, Wilkins R, Toh BH, Cooper ME, Chai Z.

J Biol Chem. 2007 Apr 20;282(16):11722-31. Epub 2007 Feb 22.


c-ABL tyrosine kinase modulates p53-dependent p21 induction and ensuing cell fate decision in response to DNA damage.

Udden SM, Morita-Fujimura Y, Satake M, Ikawa S.

Cell Signal. 2014 Feb;26(2):444-52. doi: 10.1016/j.cellsig.2013.10.005. Epub 2013 Oct 28.


SPRR2A enhances p53 deacetylation through HDAC1 and down regulates p21 promoter activity.

Mizuguchi Y, Specht S, Lunz JG 3rd, Isse K, Corbitt N, Takizawa T, Demetris AJ.

BMC Mol Biol. 2012 Jun 25;13:20. doi: 10.1186/1471-2199-13-20.


Induction of cell cycle arrest and apoptosis by betulinic acid-rich fraction from Dillenia suffruticosa root in MCF-7 cells involved p53/p21 and mitochondrial signalling pathway.

Foo JB, Saiful Yazan L, Tor YS, Wibowo A, Ismail N, How CW, Armania N, Loh SP, Ismail IS, Cheah YK, Abdullah R.

J Ethnopharmacol. 2015 May 26;166:270-8. doi: 10.1016/j.jep.2015.03.039. Epub 2015 Mar 19.


Fuse binding protein antagonizes the transcription activity of tumor suppressor protein p53.

Dixit U, Liu Z, Pandey AK, Kothari R, Pandey VN.

BMC Cancer. 2014 Dec 8;14:925. doi: 10.1186/1471-2407-14-925.

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