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Items: 1 to 20 of 124

1.

Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents.

Liu YQ, Li XJ, Zhao CY, Nan X, Tian J, Morris-Natschke SL, Zhang ZJ, Yang XM, Yang L, Li LH, Zhou XW, Lee KH.

Bioorg Med Chem. 2013 Mar 1;21(5):1248-56. doi: 10.1016/j.bmc.2012.12.046. Epub 2013 Jan 9.

PMID:
23369687
2.

Synthesis and biological evaluation of a series of podophyllotoxins derivatives as a class of potent antitubulin agents.

Liu Y, Wei D, Zhao Y, Cheng W, Lu Y, Ma Y, Li X, Han C, Wei Y, Cao H, Zhao C.

Bioorg Med Chem. 2012 Nov 1;20(21):6285-95. doi: 10.1016/j.bmc.2012.09.009. Epub 2012 Sep 13.

PMID:
23022053
3.

Synthesis and biological evaluation of 1,2,3-triazole linked aminocombretastatin conjugates as mitochondrial mediated apoptosis inducers.

Kamal A, Shaik B, Nayak VL, Nagaraju B, Kapure JS, Shaheer Malik M, Shaik TB, Prasad B.

Bioorg Med Chem. 2014 Oct 1;22(19):5155-67. doi: 10.1016/j.bmc.2014.08.008. Epub 2014 Aug 19.

PMID:
25192811
4.

Discovery of isoerianin analogues as promising anticancer agents.

Messaoudi S, Hamze A, Provot O, Tréguier B, Rodrigo De Losada J, Bignon J, Liu JM, Wdzieczak-Bakala J, Thoret S, Dubois J, Brion JD, Alami M.

ChemMedChem. 2011 Mar 7;6(3):488-97. doi: 10.1002/cmdc.201000456. Epub 2011 Jan 14. Erratum in: ChemMedChem. 2011 May 2;6(5):750.

PMID:
21360820
5.

Isocombretastatins A: 1,1-diarylethenes as potent inhibitors of tubulin polymerization and cytotoxic compounds.

Alvarez R, Alvarez C, Mollinedo F, Sierra BG, Medarde M, Peláez R.

Bioorg Med Chem. 2009 Sep 1;17(17):6422-31. doi: 10.1016/j.bmc.2009.07.012. Epub 2009 Jul 9.

PMID:
19647439
6.

Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues.

Guan Q, Zuo D, Jiang N, Qi H, Zhai Y, Bai Z, Feng D, Yang L, Jiang M, Bao K, Li C, Wu Y, Zhang W.

Bioorg Med Chem Lett. 2015 Feb 1;25(3):631-4. doi: 10.1016/j.bmcl.2014.12.004. Epub 2014 Dec 8.

PMID:
25529737
7.

Synthesis and antitumor activity of 1,5-disubstituted 1,2,4-triazoles as cis-restricted combretastatin analogues.

Romagnoli R, Baraldi PG, Cruz-Lopez O, Lopez Cara C, Carrion MD, Brancale A, Hamel E, Chen L, Bortolozzi R, Basso G, Viola G.

J Med Chem. 2010 May 27;53(10):4248-58. doi: 10.1021/jm100245q.

8.

4,5-Diaryl-3H-1,2-dithiole-3-thiones and related compounds as combretastatin A-4/oltipraz hybrids: Synthesis, molecular modelling and evaluation as antiproliferative agents and inhibitors of tubulin.

Wang Z, Qi H, Shen Q, Lu G, Li M, Bao K, Wu Y, Zhang W.

Eur J Med Chem. 2016 Oct 21;122:520-529. doi: 10.1016/j.ejmech.2016.06.055. Epub 2016 Jul 1.

PMID:
27428395
9.

2-amino-3,4,5-trimethoxybenzophenones as potent tubulin polymerization inhibitors.

Chuang HY, Chang JY, Lai MJ, Kuo CC, Lee HY, Hsieh HP, Chen YJ, Chen LT, Pan WY, Liou JP.

ChemMedChem. 2011 Mar 7;6(3):450-6. doi: 10.1002/cmdc.201000479. Epub 2011 Jan 4.

PMID:
21360819
10.

Combretastatin-like chalcones as inhibitors of microtubule polymerization. Part 1: synthesis and biological evaluation of antivascular activity.

Ducki S, Rennison D, Woo M, Kendall A, Chabert JF, McGown AT, Lawrence NJ.

Bioorg Med Chem. 2009 Nov 15;17(22):7698-710. doi: 10.1016/j.bmc.2009.09.039. Epub 2009 Sep 25.

PMID:
19837593
11.

Synthesis and biological evaluation of 3,4-diaryl-5-aminoisoxazole derivatives.

Liu T, Dong X, Xue N, Wu R, He Q, Yang B, Hu Y.

Bioorg Med Chem. 2009 Sep 1;17(17):6279-85. doi: 10.1016/j.bmc.2009.07.040. Epub 2009 Jul 23.

PMID:
19665898
12.

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.

Eur J Med Chem. 2015 Apr 13;94:447-57. doi: 10.1016/j.ejmech.2015.02.058. Epub 2015 Mar 3.

PMID:
25828827
13.

Design and synthesis of aminostilbene-arylpropenones as tubulin polymerization inhibitors.

Kamal A, Kumar GB, Polepalli S, Shaik AB, Reddy VS, Reddy MK, Reddy ChR, Mahesh R, Kapure JS, Jain N.

ChemMedChem. 2014 Nov;9(11):2565-79. doi: 10.1002/cmdc.201402256. Epub 2014 Aug 21.

PMID:
25146959
14.

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.

Bioorg Med Chem. 2014 May 1;22(9):2714-23. doi: 10.1016/j.bmc.2014.03.021. Epub 2014 Mar 22.

PMID:
24721832
15.
16.

Design, synthesis, biological evaluation and molecular modeling study of novel macrocyclic bisbibenzyl analogues as antitubulin agents.

Sun B, Li L, Hu QW, Zheng HB, Tang H, Niu HM, Yuan HQ, Lou HX.

Eur J Med Chem. 2017 Mar 31;129:186-208. doi: 10.1016/j.ejmech.2017.02.021. Epub 2017 Feb 10.

PMID:
28222318
17.

Conformationnally restricted naphthalene derivatives type isocombretastatin A-4 and isoerianin analogues: synthesis, cytotoxicity and antitubulin activity.

Rasolofonjatovo E, Provot O, Hamze A, Rodrigo J, Bignon J, Wdzieczak-Bakala J, Desravines D, Dubois J, Brion JD, Alami M.

Eur J Med Chem. 2012 Jun;52:22-32. doi: 10.1016/j.ejmech.2012.03.001. Epub 2012 Mar 9.

PMID:
22449653
18.

Combretastatin linked 1,3,4-oxadiazole conjugates as a Potent Tubulin Polymerization inhibitors.

Kamal A, Srikanth PS, Vishnuvardhan MV, Kumar GB, Suresh Babu K, Hussaini SM, Kapure JS, Alarifi A.

Bioorg Chem. 2016 Apr;65:126-36. doi: 10.1016/j.bioorg.2016.02.007. Epub 2016 Feb 26.

PMID:
26943479
19.

Investigation of podophyllotoxin esters as potential anticancer agents: synthesis, biological studies and tubulin inhibition properties.

Shareef MA, Duscharla D, Ramasatyaveni G, Dhoke NR, Das A, Ummanni R, Srivastava AK.

Eur J Med Chem. 2015 Jan 7;89:128-37. doi: 10.1016/j.ejmech.2014.10.050. Epub 2014 Oct 18.

PMID:
25462233
20.

Design, synthesis and biological evaluation of millepachine derivatives as a new class of tubulin polymerization inhibitors.

Wang G, Peng F, Cao D, Yang Z, Han X, Liu J, Wu W, He L, Ma L, Chen J, Sang Y, Xiang M, Peng A, Wei Y, Chen L.

Bioorg Med Chem. 2013 Nov 1;21(21):6844-54. doi: 10.1016/j.bmc.2013.02.002. Epub 2013 Feb 13.

PMID:
23993668

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