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Items: 1 to 20 of 123

1.

Frequent and variable cytotoxic-T-lymphocyte escape-associated fitness costs in the human immunodeficiency virus type 1 subtype B Gag proteins.

Boutwell CL, Carlson JM, Lin TH, Seese A, Power KA, Peng J, Tang Y, Brumme ZL, Heckerman D, Schneidewind A, Allen TM.

J Virol. 2013 Apr;87(7):3952-65. doi: 10.1128/JVI.03233-12. Epub 2013 Jan 30.

2.

Variable fitness impact of HIV-1 escape mutations to cytotoxic T lymphocyte (CTL) response.

Troyer RM, McNevin J, Liu Y, Zhang SC, Krizan RW, Abraha A, Tebit DM, Zhao H, Avila S, Lobritz MA, McElrath MJ, Le Gall S, Mullins JI, Arts EJ.

PLoS Pathog. 2009 Apr;5(4):e1000365. doi: 10.1371/journal.ppat.1000365. Epub 2009 Apr 3.

3.

Consequences of HLA-B*13-Associated Escape Mutations on HIV-1 Replication and Nef Function.

Shahid A, Olvera A, Anmole G, Kuang XT, Cotton LA, Plana M, Brander C, Brockman MA, Brumme ZL.

J Virol. 2015 Nov;89(22):11557-71. doi: 10.1128/JVI.01955-15. Epub 2015 Sep 9.

4.

HIV-1 replication fitness of HLA-B*57/58:01 CTL escape variants is restored by the accumulation of compensatory mutations in gag.

Gijsbers EF, Feenstra KA, van Nuenen AC, Navis M, Heringa J, Schuitemaker H, Kootstra NA.

PLoS One. 2013 Dec 5;8(12):e81235. doi: 10.1371/journal.pone.0081235. eCollection 2013.

5.

Impact of immune escape mutations on HIV-1 fitness in the context of the cognate transmitted/founder genome.

Song H, Pavlicek JW, Cai F, Bhattacharya T, Li H, Iyer SS, Bar KJ, Decker JM, Goonetilleke N, Liu MK, Berg A, Hora B, Drinker MS, Eudailey J, Pickeral J, Moody MA, Ferrari G, McMichael A, Perelson AS, Shaw GM, Hahn BH, Haynes BF, Gao F.

Retrovirology. 2012 Oct 30;9:89. doi: 10.1186/1742-4690-9-89.

6.
7.

Functional consequences of human immunodeficiency virus escape from an HLA-B*13-restricted CD8+ T-cell epitope in p1 Gag protein.

Prado JG, Honeyborne I, Brierley I, Puertas MC, Martinez-Picado J, Goulder PJ.

J Virol. 2009 Jan;83(2):1018-25. doi: 10.1128/JVI.01882-08. Epub 2008 Oct 22.

8.

Fitness-Balanced Escape Determines Resolution of Dynamic Founder Virus Escape Processes in HIV-1 Infection.

Sunshine JE, Larsen BB, Maust B, Casey E, Deng W, Chen L, Westfall DH, Kim M, Zhao H, Ghorai S, Lanxon-Cookson E, Rolland M, Collier AC, Maenza J, Mullins JI, Frahm N.

J Virol. 2015 Oct;89(20):10303-18. doi: 10.1128/JVI.01876-15. Epub 2015 Jul 29.

9.
10.

Early selection in Gag by protective HLA alleles contributes to reduced HIV-1 replication capacity that may be largely compensated for in chronic infection.

Brockman MA, Brumme ZL, Brumme CJ, Miura T, Sela J, Rosato PC, Kadie CM, Carlson JM, Markle TJ, Streeck H, Kelleher AD, Markowitz M, Jessen H, Rosenberg E, Altfeld M, Harrigan PR, Heckerman D, Walker BD, Allen TM.

J Virol. 2010 Nov;84(22):11937-49. doi: 10.1128/JVI.01086-10. Epub 2010 Sep 1.

11.

Effects of Mutations on Replicative Fitness and Major Histocompatibility Complex Class I Binding Affinity Are Among the Determinants Underlying Cytotoxic-T-Lymphocyte Escape of HIV-1 Gag Epitopes.

Du Y, Zhang TH, Dai L, Zheng X, Gorin AM, Oishi J, Wu TT, Yoshizawa JM, Li X, Yang OO, Martinez-Maza O, Detels R, Sun R.

MBio. 2017 Nov 28;8(6). pii: e01050-17. doi: 10.1128/mBio.01050-17.

12.

Changes in HIV-1 Capsid Stability Induced by Common Cytotoxic-T-Lymphocyte-Driven Viral Sequence Mutations.

Schommers P, Martrus G, Matschl U, Sirignano M, Lütgehetmann M, Richert L, Hope TJ, Fätkenheuer G, Altfeld M.

J Virol. 2016 Jul 27;90(16):7579-86. doi: 10.1128/JVI.00867-16. Print 2016 Aug 15.

13.

Escape and compensation from early HLA-B57-mediated cytotoxic T-lymphocyte pressure on human immunodeficiency virus type 1 Gag alter capsid interactions with cyclophilin A.

Brockman MA, Schneidewind A, Lahaie M, Schmidt A, Miura T, Desouza I, Ryvkin F, Derdeyn CA, Allen S, Hunter E, Mulenga J, Goepfert PA, Walker BD, Allen TM.

J Virol. 2007 Nov;81(22):12608-18. Epub 2007 Aug 29.

14.

Accumulation of Pol Mutations Selected by HLA-B*52:01-C*12:02 Protective Haplotype-Restricted Cytotoxic T Lymphocytes Causes Low Plasma Viral Load Due to Low Viral Fitness of Mutant Viruses.

Murakoshi H, Koyanagi M, Chikata T, Rahman MA, Kuse N, Sakai K, Gatanaga H, Oka S, Takiguchi M.

J Virol. 2017 Jan 31;91(4). pii: e02082-16. doi: 10.1128/JVI.02082-16. Print 2017 Feb 15.

15.

Gag-protease-mediated replication capacity in HIV-1 subtype C chronic infection: associations with HLA type and clinical parameters.

Wright JK, Brumme ZL, Carlson JM, Heckerman D, Kadie CM, Brumme CJ, Wang B, Losina E, Miura T, Chonco F, van der Stok M, Mncube Z, Bishop K, Goulder PJ, Walker BD, Brockman MA, Ndung'u T.

J Virol. 2010 Oct;84(20):10820-31. doi: 10.1128/JVI.01084-10. Epub 2010 Aug 11.

16.

Determinants of human immunodeficiency virus type 1 escape from the primary CD8+ cytotoxic T lymphocyte response.

Jones NA, Wei X, Flower DR, Wong M, Michor F, Saag MS, Hahn BH, Nowak MA, Shaw GM, Borrow P.

J Exp Med. 2004 Nov 15;200(10):1243-56.

17.

Gag cytotoxic T lymphocyte escape mutations can increase sensitivity of HIV-1 to human TRIM5alpha, linking intrinsic and acquired immunity.

Battivelli E, Migraine J, Lecossier D, Yeni P, Clavel F, Hance AJ.

J Virol. 2011 Nov;85(22):11846-54. doi: 10.1128/JVI.05201-11. Epub 2011 Sep 14.

18.

The route of HIV escape from immune response targeting multiple sites is determined by the cost-benefit tradeoff of escape mutations.

Batorsky R, Sergeev RA, Rouzine IM.

PLoS Comput Biol. 2014 Oct 30;10(10):e1003878. doi: 10.1371/journal.pcbi.1003878. eCollection 2014 Oct.

19.

Impaired processing and presentation of cytotoxic-T-lymphocyte (CTL) epitopes are major escape mechanisms from CTL immune pressure in human immunodeficiency virus type 1 infection.

Yokomaku Y, Miura H, Tomiyama H, Kawana-Tachikawa A, Takiguchi M, Kojima A, Nagai Y, Iwamoto A, Matsuda Z, Ariyoshi K.

J Virol. 2004 Feb;78(3):1324-32.

20.

Escape from the dominant HLA-B27-restricted cytotoxic T-lymphocyte response in Gag is associated with a dramatic reduction in human immunodeficiency virus type 1 replication.

Schneidewind A, Brockman MA, Yang R, Adam RI, Li B, Le Gall S, Rinaldo CR, Craggs SL, Allgaier RL, Power KA, Kuntzen T, Tung CS, LaBute MX, Mueller SM, Harrer T, McMichael AJ, Goulder PJ, Aiken C, Brander C, Kelleher AD, Allen TM.

J Virol. 2007 Nov;81(22):12382-93. Epub 2007 Sep 5.

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