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Items: 1 to 20 of 96

1.

Exogenous delivery of chaperonin subunit fragment ApiCCT1 modulates mutant Huntingtin cellular phenotypes.

Sontag EM, Joachimiak LA, Tan Z, Tomlinson A, Housman DE, Glabe CG, Potkin SG, Frydman J, Thompson LM.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):3077-82. doi: 10.1073/pnas.1222663110. Epub 2013 Jan 30.

2.

TRiC subunits enhance BDNF axonal transport and rescue striatal atrophy in Huntington's disease.

Zhao X, Chen XQ, Han E, Hu Y, Paik P, Ding Z, Overman J, Lau AL, Shahmoradian SH, Chiu W, Thompson LM, Wu C, Mobley WC.

Proc Natl Acad Sci U S A. 2016 Sep 20;113(38):E5655-64. doi: 10.1073/pnas.1603020113. Epub 2016 Sep 6.

3.

Structural Mechanisms of Mutant Huntingtin Aggregation Suppression by the Synthetic Chaperonin-like CCT5 Complex Explained by Cryoelectron Tomography.

Darrow MC, Sergeeva OA, Isas JM, Galaz-Montoya JG, King JA, Langen R, Schmid MF, Chiu W.

J Biol Chem. 2015 Jul 10;290(28):17451-61. doi: 10.1074/jbc.M115.655373. Epub 2015 May 20.

4.

The chaperonin TRiC controls polyglutamine aggregation and toxicity through subunit-specific interactions.

Tam S, Geller R, Spiess C, Frydman J.

Nat Cell Biol. 2006 Oct;8(10):1155-62. Epub 2006 Sep 17.

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Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.

Hogel M, Laprairie RB, Denovan-Wright EM.

PLoS One. 2012;7(7):e41152. doi: 10.1371/journal.pone.0041152. Epub 2012 Jul 18.

8.

Identification of novel potentially toxic oligomers formed in vitro from mammalian-derived expanded huntingtin exon-1 protein.

Nucifora LG, Burke KA, Feng X, Arbez N, Zhu S, Miller J, Yang G, Ratovitski T, Delannoy M, Muchowski PJ, Finkbeiner S, Legleiter J, Ross CA, Poirier MA.

J Biol Chem. 2012 May 4;287(19):16017-28. doi: 10.1074/jbc.M111.252577. Epub 2012 Mar 20.

9.

Progressive phenotype and nuclear accumulation of an amino-terminal cleavage fragment in a transgenic mouse model with inducible expression of full-length mutant huntingtin.

Tanaka Y, Igarashi S, Nakamura M, Gafni J, Torcassi C, Schilling G, Crippen D, Wood JD, Sawa A, Jenkins NA, Copeland NG, Borchelt DR, Ross CA, Ellerby LM.

Neurobiol Dis. 2006 Feb;21(2):381-91. Epub 2005 Sep 16.

PMID:
16150600
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12.

Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice.

Pitzer M, Lueras J, Warden A, Weber S, McBride J.

Brain Res. 2015 May 22;1608:177-90. doi: 10.1016/j.brainres.2015.02.027. Epub 2015 Feb 28.

13.

Changes in BiP availability reveal hypersensitivity to acute endoplasmic reticulum stress in cells expressing mutant huntingtin.

Lajoie P, Snapp EL.

J Cell Sci. 2011 Oct 1;124(Pt 19):3332-43. doi: 10.1242/jcs.087510. Epub 2011 Sep 6. Erratum in: J Cell Sci. 2012 Feb 1;125(Pt 3):789.

14.

Fragments of HdhQ150 mutant huntingtin form a soluble oligomer pool that declines with aggregate deposition upon aging.

Marcellin D, Abramowski D, Young D, Richter J, Weiss A, Marcel A, Maassen J, Kauffmann M, Bibel M, Shimshek DR, Faull RL, Bates GP, Kuhn RR, Van der Putten PH, Schmid P, Lotz GP.

PLoS One. 2012;7(9):e44457. doi: 10.1371/journal.pone.0044457. Epub 2012 Sep 12.

15.

Truncated N-terminal fragments of huntingtin with expanded glutamine repeats form nuclear and cytoplasmic aggregates in cell culture.

Cooper JK, Schilling G, Peters MF, Herring WJ, Sharp AH, Kaminsky Z, Masone J, Khan FA, Delanoy M, Borchelt DR, Dawson VL, Dawson TM, Ross CA.

Hum Mol Genet. 1998 May;7(5):783-90.

PMID:
9536081
16.

Mutant huntingtin expression in clonal striatal cells: dissociation of inclusion formation and neuronal survival by caspase inhibition.

Kim M, Lee HS, LaForet G, McIntyre C, Martin EJ, Chang P, Kim TW, Williams M, Reddy PH, Tagle D, Boyce FM, Won L, Heller A, Aronin N, DiFiglia M.

J Neurosci. 1999 Feb 1;19(3):964-73.

18.

Genetic background modifies nuclear mutant huntingtin accumulation and HD CAG repeat instability in Huntington's disease knock-in mice.

Lloret A, Dragileva E, Teed A, Espinola J, Fossale E, Gillis T, Lopez E, Myers RH, MacDonald ME, Wheeler VC.

Hum Mol Genet. 2006 Jun 15;15(12):2015-24. Epub 2006 May 10.

PMID:
16687439
19.

Glutathione redox cycle dysregulation in Huntington's disease knock-in striatal cells.

Ribeiro M, Rosenstock TR, Cunha-Oliveira T, Ferreira IL, Oliveira CR, Rego AC.

Free Radic Biol Med. 2012 Nov 15;53(10):1857-67. doi: 10.1016/j.freeradbiomed.2012.09.004. Epub 2012 Sep 14.

PMID:
22982598
20.

Cysteine oxidation within N-terminal mutant huntingtin promotes oligomerization and delays clearance of soluble protein.

Fox JH, Connor T, Stiles M, Kama J, Lu Z, Dorsey K, Lieberman G, Sapp E, Cherny RA, Banks M, Volitakis I, DiFiglia M, Berezovska O, Bush AI, Hersch SM.

J Biol Chem. 2011 May 20;286(20):18320-30. doi: 10.1074/jbc.M110.199448. Epub 2011 Mar 30. Erratum in: J Biol Chem. 2011 Jul 29;286(30):27068. Liebermann, Gregory [corrected to Lieberman, Gregory].

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