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Items: 1 to 20 of 96

1.

Inhibition of G-protein-coupled receptor kinase 2 (GRK2) triggers the growth-promoting mitogen-activated protein kinase (MAPK) pathway.

Fu X, Koller S, Abd Alla J, Quitterer U.

J Biol Chem. 2013 Mar 15;288(11):7738-55. doi: 10.1074/jbc.M112.428078. Epub 2013 Jan 28.

2.

Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.

Abd Alla J, Graemer M, Fu X, Quitterer U.

J Biol Chem. 2016 Feb 5;291(6):2583-600. doi: 10.1074/jbc.M115.702688. Epub 2015 Dec 15.

3.

G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the ERK MAP kinase cascade.

Robinson JD, Pitcher JA.

Cell Signal. 2013 Dec;25(12):2831-9. doi: 10.1016/j.cellsig.2013.08.031. Epub 2013 Sep 7.

4.

Gβγ-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor α-induced cardiac β-adrenergic receptor dysfunction.

Vasudevan NT, Mohan ML, Gupta MK, Martelli EE, Hussain AK, Qin Y, Chandrasekharan UM, Young D, Feldman AM, Sen S, Dorn GW 2nd, Dicorleto PE, Naga Prasad SV.

Circulation. 2013 Jul 23;128(4):377-87. doi: 10.1161/CIRCULATIONAHA.113.003183. Epub 2013 Jun 19.

5.

Prodeath signaling of G protein-coupled receptor kinase 2 in cardiac myocytes after ischemic stress occurs via extracellular signal-regulated kinase-dependent heat shock protein 90-mediated mitochondrial targeting.

Chen M, Sato PY, Chuprun JK, Peroutka RJ, Otis NJ, Ibetti J, Pan S, Sheu SS, Gao E, Koch WJ.

Circ Res. 2013 Apr 12;112(8):1121-34. doi: 10.1161/CIRCRESAHA.112.300754. Epub 2013 Mar 6.

6.

Raf kinase inhibitor protein (RKIP) dimer formation controls its target switch from Raf1 to G protein-coupled receptor kinase (GRK) 2.

Deiss K, Kisker C, Lohse MJ, Lorenz K.

J Biol Chem. 2012 Jul 6;287(28):23407-17. doi: 10.1074/jbc.M112.363812. Epub 2012 May 17.

7.

Gi-biased β2AR signaling links GRK2 upregulation to heart failure.

Zhu W, Petrashevskaya N, Ren S, Zhao A, Chakir K, Gao E, Chuprun JK, Wang Y, Talan M, Dorn GW 2nd, Lakatta EG, Koch WJ, Feldman AM, Xiao RP.

Circ Res. 2012 Jan 20;110(2):265-74. doi: 10.1161/CIRCRESAHA.111.253260. Epub 2011 Dec 15.

8.

G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.

Raake PW, Vinge LE, Gao E, Boucher M, Rengo G, Chen X, DeGeorge BR Jr, Matkovich S, Houser SR, Most P, Eckhart AD, Dorn GW 2nd, Koch WJ.

Circ Res. 2008 Aug 15;103(4):413-22. doi: 10.1161/CIRCRESAHA.107.168336. Epub 2008 Jul 17.

9.

G protein-coupled receptor kinase 2 activity impairs cardiac glucose uptake and promotes insulin resistance after myocardial ischemia.

Ciccarelli M, Chuprun JK, Rengo G, Gao E, Wei Z, Peroutka RJ, Gold JI, Gumpert A, Chen M, Otis NJ, Dorn GW 2nd, Trimarco B, Iaccarino G, Koch WJ.

Circulation. 2011 May 10;123(18):1953-62. doi: 10.1161/CIRCULATIONAHA.110.988642. Epub 2011 Apr 25.

10.

Downregulation of G protein-coupled receptor kinase 2 levels enhances cardiac insulin sensitivity and switches on cardioprotective gene expression patterns.

Lucas E, Jurado-Pueyo M, Fortuño MA, Fernández-Veledo S, Vila-Bedmar R, Jiménez-Borreguero LJ, Lazcano JJ, Gao E, Gómez-Ambrosi J, Frühbeck G, Koch WJ, Díez J, Mayor F Jr, Murga C.

Biochim Biophys Acta. 2014 Dec;1842(12 Pt A):2448-56. doi: 10.1016/j.bbadis.2014.09.004. Epub 2014 Sep 18.

11.

Regulation of mGlu4 metabotropic glutamate receptor signaling by type-2 G-protein coupled receptor kinase (GRK2).

Iacovelli L, Capobianco L, Iula M, Di Giorgi Gerevini V, Picascia A, Blahos J, Melchiorri D, Nicoletti F, De Blasi A.

Mol Pharmacol. 2004 May;65(5):1103-10.

12.

G alpha(q)-mediated activation of GRK2 by mechanical stretch in cardiac myocytes: the role of protein kinase C.

Malhotra R, D'Souza KM, Staron ML, Birukov KG, Bodi I, Akhter SA.

J Biol Chem. 2010 Apr 30;285(18):13748-60. doi: 10.1074/jbc.M110.109272. Epub 2010 Mar 1. Retraction in: Malhotra R, D'Souza KM, Staron ML, Birukov KG, Bodi I, Akhter SA. J Biol Chem. 2016 Jul 1;291(27):14390.

13.

GRK2-dependent desensitization downstream of G proteins.

Jurado-Pueyo M, Campos PM, Mayor F, Murga C.

J Recept Signal Transduct Res. 2008;28(1-2):59-70. doi: 10.1080/10799890801941939 . Review.

PMID:
18437630
15.

Multiple scaffolding functions of {beta}-arrestins in the degradation of G protein-coupled receptor kinase 2.

Nogués L, Salcedo A, Mayor F Jr, Penela P.

J Biol Chem. 2011 Jan 14;286(2):1165-73. doi: 10.1074/jbc.M110.203406. Epub 2010 Nov 16.

16.

Tonic inhibition by G protein-coupled receptor kinase 2 of Akt/endothelial nitric-oxide synthase signaling in human vascular endothelial cells under conditions of hyperglycemia with high insulin levels.

Taguchi K, Sakata K, Ohashi W, Imaizumi T, Imura J, Hattori Y.

J Pharmacol Exp Ther. 2014 May;349(2):199-208. doi: 10.1124/jpet.113.211854. Epub 2014 Feb 25.

17.

Regulation of the epithelial Na+ channel by the RH domain of G protein-coupled receptor kinase, GRK2, and Galphaq/11.

Lee IH, Song SH, Campbell CR, Kumar S, Cook DI, Dinudom A.

J Biol Chem. 2011 Jun 3;286(22):19259-69. doi: 10.1074/jbc.M111.239772. Epub 2011 Apr 4.

18.

Integrating GRK2 and NFkappaB in the Pathophysiology of Cardiac Hypertrophy.

Sorriento D, Santulli G, Franco A, Cipolletta E, Napolitano L, Gambardella J, Gomez-Monterrey I, Campiglia P, Trimarco B, Iaccarino G, Ciccarelli M.

J Cardiovasc Transl Res. 2015 Nov;8(8):493-502. doi: 10.1007/s12265-015-9646-0. Epub 2015 Jul 30.

PMID:
26224342
19.

Regulation of EGF-induced ERK/MAPK activation and EGFR internalization by G protein-coupled receptor kinase 2.

Gao J, Li J, Ma L.

Acta Biochim Biophys Sin (Shanghai). 2005 Aug;37(8):525-31.

20.

Growth inhibition of human hepatocellular carcinoma cells by overexpression of G-protein-coupled receptor kinase 2.

Wei Z, Hurtt R, Ciccarelli M, Koch WJ, Doria C.

J Cell Physiol. 2012 Jun;227(6):2371-7. doi: 10.1002/jcp.22972.

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