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Perturbation of bile acid homeostasis is an early pathogenesis event of drug induced liver injury in rats.

Yamazaki M, Miyake M, Sato H, Masutomi N, Tsutsui N, Adam KP, Alexander DC, Lawton KA, Milburn MV, Ryals JA, Wulff JE, Guo L.

Toxicol Appl Pharmacol. 2013 Apr 1;268(1):79-89. doi: 10.1016/j.taap.2013.01.018. Epub 2013 Jan 27.


Quantitative targeted bile acid profiling as new markers for DILI in a model of methapyrilene-induced liver injury in rats.

Slopianka M, Herrmann A, Pavkovic M, Ellinger-Ziegelbauer H, Ernst R, Mally A, Keck M, Riefke B.

Toxicology. 2017 Jul 1;386:1-10. doi: 10.1016/j.tox.2017.05.009. Epub 2017 May 19.


Increased serum bile acid concentration following low-dose chronic administration of thioacetamide in rats, as evidenced by metabolomic analysis.

Jeong ES, Kim G, Shin HJ, Park SM, Oh JH, Kim YB, Moon KS, Choi HK, Jeong J, Shin JG, Kim DH.

Toxicol Appl Pharmacol. 2015 Oct 15;288(2):213-22. doi: 10.1016/j.taap.2015.07.016. Epub 2015 Jul 26.


Promising toxicological biomarkers for the diagnosis of liver injury types: Bile acid metabolic profiles and oxidative stress marker as screening tools in drug development.

Masubuchi N, Nishiya T, Imaoka M, Mizumaki K, Okazaki O.

Chem Biol Interact. 2016 Aug 5;255:74-82. doi: 10.1016/j.cbi.2015.09.012. Epub 2015 Sep 11.


Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophen and methotrexate by mass spectrometry-based metabolomics.

Kumar BS, Chung BC, Kwon OS, Jung BH.

J Appl Toxicol. 2012 Jul;32(7):505-20. doi: 10.1002/jat.1746. Epub 2011 Dec 1.


Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes.

Ogimura E, Sekine S, Horie T.

Biochem Biophys Res Commun. 2011 Dec 16;416(3-4):313-7. doi: 10.1016/j.bbrc.2011.11.032. Epub 2011 Nov 15.


Development of analytical method for simultaneous determination of five rodent unique bile acids in rat plasma using ultra-performance liquid chromatography coupled with time-of-flight mass spectrometry.

Minato K, Suzuki M, Nagao H, Suzuki R, Ochiai H.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:399-410. doi: 10.1016/j.jchromb.2015.08.047. Epub 2015 Sep 3.


Bile acids metabonomic study on the CCl4- and alpha-naphthylisothiocyanate-induced animal models: quantitative analysis of 22 bile acids by ultraperformance liquid chromatography-mass spectrometry.

Yang L, Xiong A, He Y, Wang Z, Wang C, Wang Z, Li W, Yang L, Hu Z.

Chem Res Toxicol. 2008 Dec;21(12):2280-8. doi: 10.1021/tx800225q.


Individual serum bile acid profiling in rats aids in human risk assessment of drug-induced liver injury due to BSEP inhibition.

Cepa S, Potter D, Wong L, Schutt L, Tarrant J, Pang J, Zhang X, Andaya R, Salphati L, Ran Y, An L, Morgan R, Maher J.

Toxicol Appl Pharmacol. 2018 Jan 1;338:204-213. doi: 10.1016/j.taap.2017.11.007. Epub 2017 Nov 13.


Bile acids in drug induced liver injury: Key players and surrogate markers.

Schadt HS, Wolf A, Pognan F, Chibout SD, Merz M, Kullak-Ublick GA.

Clin Res Hepatol Gastroenterol. 2016 Jun;40(3):257-266. doi: 10.1016/j.clinre.2015.12.017. Epub 2016 Feb 10. Review.


Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay.

Susukida T, Sekine S, Nozaki M, Tokizono M, Ito K.

Drug Metab Dispos. 2015 Nov;43(11):1760-8. doi: 10.1124/dmd.115.065425. Epub 2015 Sep 1. Erratum in: Drug Metab Dispos. 2016 Mar;44(3):336.


UPLC-MS-based serum metabonomics for identifying acute liver injury biomarkers in Chinese miniature pigs.

Ma J, Yu J, Su X, Zhu C, Yang X, Sun H, Chen D, Wang Y, Cao H, Lu J.

Toxicol Lett. 2014 Mar 21;225(3):358-66. doi: 10.1016/j.toxlet.2014.01.008. Epub 2014 Jan 19.


Evaluation of serum bile acid profiles as biomarkers of liver injury in rodents.

Luo L, Schomaker S, Houle C, Aubrecht J, Colangelo JL.

Toxicol Sci. 2014 Jan;137(1):12-25. doi: 10.1093/toxsci/kft221. Epub 2013 Oct 1.


Hepatotoxin-induced hypercreatinaemia and hypercreatinuria: their relationship to one another, to liver damage and to weakened nutritional status.

Clayton TA, Lindon JC, Everett JR, Charuel C, Hanton G, Le Net JL, Provost JP, Nicholson JK.

Arch Toxicol. 2004 Feb;78(2):86-96. Epub 2003 Oct 1.


Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma.

Mattes W, Davis K, Fabian E, Greenhaw J, Herold M, Looser R, Mellert W, Groeters S, Marxfeld H, Moeller N, Montoya-Parra G, Prokoudine A, van Ravenzwaay B, Strauss V, Walk T, Kamp H.

Toxicol Lett. 2014 Nov 4;230(3):467-78. doi: 10.1016/j.toxlet.2014.07.021. Epub 2014 Jul 31.


Combined effects of a high-fat diet and chronic valproic acid treatment on hepatic steatosis and hepatotoxicity in rats.

Zhang LF, Liu LS, Chu XM, Xie H, Cao LJ, Guo C, A JY, Cao B, Li MJ, Wang GJ, Hao HP.

Acta Pharmacol Sin. 2014 Mar;35(3):363-72. doi: 10.1038/aps.2013.135. Epub 2014 Jan 20.


Evaluation of the potential for drug-induced liver injury based on in vitro covalent binding to human liver proteins.

Usui T, Mise M, Hashizume T, Yabuki M, Komuro S.

Drug Metab Dispos. 2009 Dec;37(12):2383-92. doi: 10.1124/dmd.109.028860. Epub 2009 Aug 31.


Usefulness of in vitro combination assays of mitochondrial dysfunction and apoptosis for the estimation of potential risk of idiosyncratic drug induced liver injury.

Goda K, Takahashi T, Kobayashi A, Shoda T, Kuno H, Sugai S.

J Toxicol Sci. 2016;41(5):605-15. doi: 10.2131/jts.41.605.


Characteristic molecular and proteomic signatures of drug-induced liver injury in a rat model.

Eun JW, Bae HJ, Shen Q, Park SJ, Kim HS, Shin WC, Yang HD, Jin CY, You JS, Kang HJ, Kim H, Ahn YM, Park WS, Lee JY, Nam SW.

J Appl Toxicol. 2015 Feb;35(2):152-64. doi: 10.1002/jat.3062. Epub 2014 Sep 18.


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