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Items: 1 to 20 of 65

1.

Highly efficient production of the Alzheimer's γ-secretase integral membrane protease complex by a multi-gene stable integration approach.

Alattia JR, Matasci M, Dimitrov M, Aeschbach L, Balasubramanian S, Hacker DL, Wurm FM, Fraering PC.

Biotechnol Bioeng. 2013 Jul;110(7):1995-2005. doi: 10.1002/bit.24851. Epub 2013 Feb 15.

PMID:
23359429
2.

Production of active glycosylation-deficient γ-secretase complex for crystallization studies.

López AR, Dimitrov M, Gerber H, Braman V, Hacker DL, Wurm FM, Fraering PC.

Biotechnol Bioeng. 2015 Dec;112(12):2516-26. doi: 10.1002/bit.25675. Epub 2015 Jul 14.

PMID:
26059427
3.

Active gamma-secretase complexes contain only one of each component.

Sato T, Diehl TS, Narayanan S, Funamoto S, Ihara Y, De Strooper B, Steiner H, Haass C, Wolfe MS.

J Biol Chem. 2007 Nov 23;282(47):33985-93. Epub 2007 Oct 2.

4.

gamma-Secretase modulators.

Wolfe MS.

Curr Alzheimer Res. 2007 Dec;4(5):571-3. Review.

PMID:
18220525
5.

Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase.

Winkler E, Hobson S, Fukumori A, Dümpelfeld B, Luebbers T, Baumann K, Haass C, Hopf C, Steiner H.

Biochemistry. 2009 Feb 17;48(6):1183-97. doi: 10.1021/bi801204g.

PMID:
19159235
6.

Rapid purification of active gamma-secretase, an intramembrane protease implicated in Alzheimer's disease.

Cacquevel M, Aeschbach L, Osenkowski P, Li D, Ye W, Wolfe MS, Li H, Selkoe DJ, Fraering PC.

J Neurochem. 2008 Jan;104(1):210-20. Epub 2007 Nov 6.

7.

Regulation of gamma-secretase activity in Alzheimer's disease.

Zhou S, Zhou H, Walian PJ, Jap BK.

Biochemistry. 2007 Mar 13;46(10):2553-63. Epub 2007 Feb 14.

PMID:
17298085
8.

Characterization of the reconstituted gamma-secretase complex from Sf9 cells co-expressing presenilin 1, nicastrin [correction of nacastrin], aph-1a, and pen-2.

Zhang L, Lee J, Song L, Sun X, Shen J, Terracina G, Parker EM.

Biochemistry. 2005 Mar 22;44(11):4450-7.

PMID:
15766275
9.

Generation of monoclonal antibody fragments binding the native γ-secretase complex for use in structural studies.

Alattia JR, Schweizer C, Cacquevel M, Dimitrov M, Aeschbach L, Oulad-Abdelghani M, Fraering PC.

Biochemistry. 2012 Nov 6;51(44):8779-90. doi: 10.1021/bi300997e. Epub 2012 Oct 25.

PMID:
23066899
10.

Begacestat (GSI-953): a novel, selective thiophene sulfonamide inhibitor of amyloid precursor protein gamma-secretase for the treatment of Alzheimer's disease.

Martone RL, Zhou H, Atchison K, Comery T, Xu JZ, Huang X, Gong X, Jin M, Kreft A, Harrison B, Mayer SC, Aschmies S, Gonzales C, Zaleska MM, Riddell DR, Wagner E, Lu P, Sun SC, Sonnenberg-Reines J, Oganesian A, Adkins K, Leach MW, Clarke DW, Huryn D, Abou-Gharbia M, Magolda R, Bard J, Frick G, Raje S, Forlow SB, Balliet C, Burczynski ME, Reinhart PH, Wan HI, Pangalos MN, Jacobsen JS.

J Pharmacol Exp Ther. 2009 Nov;331(2):598-608. doi: 10.1124/jpet.109.152975. Epub 2009 Aug 11.

11.

Effects of sulindac sulfide on the membrane architecture and the activity of gamma-secretase.

Gamerdinger M, Clement AB, Behl C.

Neuropharmacology. 2008 May;54(6):998-1005. doi: 10.1016/j.neuropharm.2008.02.009. Epub 2008 Feb 19.

PMID:
18359496
12.

Secretase inhibitors and modulators for Alzheimer's disease treatment.

Tomita T.

Expert Rev Neurother. 2009 May;9(5):661-79. doi: 10.1586/ern.09.24. Review.

PMID:
19402777
13.

In vitro gamma-secretase cleavage of the Alzheimer's amyloid precursor protein correlates to a subset of presenilin complexes and is inhibited by zinc.

Hoke DE, Tan JL, Ilaya NT, Culvenor JG, Smith SJ, White AR, Masters CL, Evin GM.

FEBS J. 2005 Nov;272(21):5544-57.

14.

Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.

Cacquevel M, Aeschbach L, Houacine J, Fraering PC.

PLoS One. 2012;7(4):e35133. doi: 10.1371/journal.pone.0035133. Epub 2012 Apr 18.

15.

The Alzheimer's disease-associated gamma-secretase complex: functional domains in the presenilin 1 protein.

Laudon H, Winblad B, Näslund J.

Physiol Behav. 2007 Sep 10;92(1-2):115-20. Epub 2007 May 21. Review.

PMID:
17588625
16.

Gamma-secretase--intramembrane protease with a complex.

Wolfe MS.

Sci Aging Knowledge Environ. 2003 Mar 19;2003(11):PE7.

PMID:
12844518
17.

Gamma-secretase is a membrane protein complex comprised of presenilin, nicastrin, Aph-1, and Pen-2.

Kimberly WT, LaVoie MJ, Ostaszewski BL, Ye W, Wolfe MS, Selkoe DJ.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6382-7. Epub 2003 May 9.

18.

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis.

Fukumori A, Fluhrer R, Steiner H, Haass C.

J Neurosci. 2010 Jun 9;30(23):7853-62. doi: 10.1523/JNEUROSCI.1443-10.2010.

19.

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity.

Wolfe MS, Xia W, Ostaszewski BL, Diehl TS, Kimberly WT, Selkoe DJ.

Nature. 1999 Apr 8;398(6727):513-7.

PMID:
10206644
20.

Generation and characterization of mutant cell lines defective in gamma-secretase processing of Notch and amyloid precursor protein.

Olry A, Chastagner P, Israël A, Brou C.

J Biol Chem. 2005 Aug 5;280(31):28564-71. Epub 2005 Jun 15.

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