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Items: 1 to 20 of 111

1.

Apoptosis-inducing activity of the actin-depolymerizing agent aplyronine A and its side-chain derivatives.

Ohno O, Morita M, Kitamura K, Teruya T, Yoneda K, Kita M, Kigoshi H, Suenaga K.

Bioorg Med Chem Lett. 2013 Mar 1;23(5):1467-71. doi: 10.1016/j.bmcl.2012.12.052. Epub 2012 Dec 25.

PMID:
23357626
2.

Synthesis of actin-depolymerizing compounds.

Kitamura K, Teruya T, Kuroda T, Kigoshi H, Suenaga K.

Bioorg Med Chem Lett. 2009 Apr 1;19(7):1896-8. doi: 10.1016/j.bmcl.2009.02.068. Epub 2009 Feb 21.

PMID:
19269172
3.

Design, synthesis, and biological evaluations of aplyronine A-mycalolide B hybrid compound.

Kobayashi K, Fujii Y, Hirayama Y, Kobayashi S, Hayakawa I, Kigoshi H.

Org Lett. 2012 Mar 2;14(5):1290-3. doi: 10.1021/ol300182r. Epub 2012 Feb 22.

PMID:
22356580
4.

Development of highly cytotoxic and actin-depolymerizing biotin derivatives of aplyronine A.

Kita M, Hirayama Y, Sugiyama M, Kigoshi H.

Angew Chem Int Ed Engl. 2011 Oct 10;50(42):9871-4. doi: 10.1002/anie.201103802. Epub 2011 Sep 27.

PMID:
21954061
5.

Study of the interaction between actin and antitumor substance aplyronine A with a novel fluorescent photoaffinity probe.

Kuroda T, Suenaga K, Sakakura A, Handa T, Okamoto K, Kigoshi H.

Bioconjug Chem. 2006 Mar-Apr;17(2):524-9.

PMID:
16536486
6.

Interactions of the antitumor macrolide aplyronine A with actin and actin-related proteins established by its versatile photoaffinity derivatives.

Kita M, Hirayama Y, Yamagishi K, Yoneda K, Fujisawa R, Kigoshi H.

J Am Chem Soc. 2012 Dec 19;134(50):20314-7. doi: 10.1021/ja310495p. Epub 2012 Dec 6.

PMID:
23198778
7.

Novel actin depolymerizing macrolide aplyronine A.

Saito S, Watabe S, Ozaki H, Kigoshi H, Yamada K, Fusetani N, Karaki H.

J Biochem. 1996 Sep;120(3):552-5.

8.

Structure basis for antitumor effect of aplyronine a.

Hirata K, Muraoka S, Suenaga K, Kuroda T, Kato K, Tanaka H, Yamamoto M, Takata M, Yamada K, Kigoshi H.

J Mol Biol. 2006 Mar 3;356(4):945-54. Epub 2005 Dec 27.

PMID:
16406066
9.

Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A.

Kita M, Hirayama Y, Yoneda K, Yamagishi K, Chinen T, Usui T, Sumiya E, Uesugi M, Kigoshi H.

J Am Chem Soc. 2013 Dec 4;135(48):18089-95. doi: 10.1021/ja406580w. Epub 2013 Nov 21.

PMID:
24228690
10.

Analysis of the aplyronine A-induced protein-protein interaction between actin and tubulin by surface plasmon resonance.

Hirayama Y, Yamagishi K, Suzuki T, Kawagishi H, Kita M, Kigoshi H.

Bioorg Med Chem. 2016 Jun 15;24(12):2809-14. doi: 10.1016/j.bmc.2016.04.049. Epub 2016 Apr 24.

PMID:
27161875
11.

Fluorescent aplyronine a: intracellular accumulation and disassembly of actin cytoskeleton in tumor cells.

Kita M, Yoneda K, Hirayama Y, Yamagishi K, Saito Y, Sugiyama Y, Miwa Y, Ohno O, Morita M, Suenaga K, Kigoshi H.

Chembiochem. 2012 Aug 13;13(12):1754-8, 1702. doi: 10.1002/cbic.201200385. Epub 2012 Jul 16. No abstract available.

PMID:
22807378
12.

A family of novel actin-inhibiting marine toxins.

Saito S, Karaki H.

Clin Exp Pharmacol Physiol. 1996 Aug;23(8):743-6.

PMID:
8886501
13.

Actin-depolymerizing effect of dimeric macrolides, bistheonellide A and swinholide A.

Saito SY, Watabe S, Ozaki H, Kobayashi M, Suzuki T, Kobayashi H, Fusetani N, Karaki H.

J Biochem. 1998 Apr;123(4):571-8.

14.

Actin depolymerizing effect of trisoxazole-containing macrolides.

Chung SC, Lee SH, Jang KH, Park W, Jeon JE, Oh H, Shin J, Oh KB.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3198-201. doi: 10.1016/j.bmcl.2011.04.069. Epub 2011 Apr 24.

PMID:
21550239
15.

Design, synthesis, and biological evaluation of simplified side chain hybrids of the potent actin binding polyketides rhizopodin and bistramide.

Herkommer D, Dreisigacker S, Sergeev G, Sasse F, Gohlke H, Menche D.

ChemMedChem. 2015 Mar;10(3):470-89. doi: 10.1002/cmdc.201402508. Epub 2015 Jan 29.

PMID:
25641798
16.

Molecular docking and QSAR of aplyronine A and analogues: potent inhibitors of actin.

Hussain A, Melville JL, Hirst JD.

J Comput Aided Mol Des. 2010 Jan;24(1):1-15. doi: 10.1007/s10822-009-9307-y. Epub 2009 Nov 5.

PMID:
19890607
17.

Synthesis and biological properties of the cytotoxic 14-membered macrolides aspergillide A and B.

Díaz-Oltra S, Angulo-Pachón CA, Murga J, Falomir E, Carda M, Marco JA.

Chemistry. 2011 Jan 10;17(2):675-88. doi: 10.1002/chem.201001682. Epub 2010 Nov 9.

PMID:
21207589
18.

Synthesis of key fragments of leiodelide A.

Chellat MF, Proust N, Lauer MG, Stambuli JP.

Org Lett. 2011 Jun 17;13(12):3246-9. doi: 10.1021/ol201183f. Epub 2011 May 25.

PMID:
21612207
19.

Synthesis and biological evaluation of (+)-neopeltolide analogues: importance of the oxazole-containing side chain.

Fuwa H, Noguchi T, Kawakami M, Sasaki M.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2415-9. doi: 10.1016/j.bmcl.2014.04.031. Epub 2014 Apr 18.

PMID:
24792465
20.

Cytotoxic and apoptosis-inducing activities of triterpene acids from Poria cocos.

Kikuchi T, Uchiyama E, Ukiya M, Tabata K, Kimura Y, Suzuki T, Akihisa T.

J Nat Prod. 2011 Feb 25;74(2):137-44. doi: 10.1021/np100402b. Epub 2011 Jan 20.

PMID:
21250700

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