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Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adults.

Wilson CL, Gough PJ, Chang CA, Chan CK, Frey JM, Liu Y, Braun KR, Chin MT, Wight TN, Raines EW.

Mech Dev. 2013 Apr-May;130(4-5):272-89. doi: 10.1016/j.mod.2013.01.001. Epub 2013 Jan 24.


Pathological neovascularization is reduced by inactivation of ADAM17 in endothelial cells but not in pericytes.

Weskamp G, Mendelson K, Swendeman S, Le Gall S, Ma Y, Lyman S, Hinoki A, Eguchi S, Guaiquil V, Horiuchi K, Blobel CP.

Circ Res. 2010 Mar 19;106(5):932-40. doi: 10.1161/CIRCRESAHA.109.207415. Epub 2010 Jan 28.


Defective valvulogenesis in HB-EGF and TACE-null mice is associated with aberrant BMP signaling.

Jackson LF, Qiu TH, Sunnarborg SW, Chang A, Zhang C, Patterson C, Lee DC.

EMBO J. 2003 Jun 2;22(11):2704-16.


Altered versican cleavage in ADAMTS5 deficient mice; a novel etiology of myxomatous valve disease.

Dupuis LE, McCulloch DR, McGarity JD, Bahan A, Wessels A, Weber D, Diminich AM, Nelson CM, Apte SS, Kern CB.

Dev Biol. 2011 Sep 1;357(1):152-64. doi: 10.1016/j.ydbio.2011.06.041. Epub 2011 Jul 1.


The chemokine receptor CXCR7 functions to regulate cardiac valve remodeling.

Yu S, Crawford D, Tsuchihashi T, Behrens TW, Srivastava D.

Dev Dyn. 2011 Feb;240(2):384-93. doi: 10.1002/dvdy.22549.


Extracellular matrix remodeling and organization in developing and diseased aortic valves.

Hinton RB Jr, Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW, Yutzey KE.

Circ Res. 2006 Jun 9;98(11):1431-8. Epub 2006 Apr 27.


Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract.

Koenig SN, Bosse K, Majumdar U, Bonachea EM, Radtke F, Garg V.

J Am Heart Assoc. 2016 Apr 22;5(4). pii: e003075. doi: 10.1161/JAHA.115.003075.


Galnt1 is required for normal heart valve development and cardiac function.

Tian E, Stevens SR, Guan Y, Springer DA, Anderson SA, Starost MF, Patel V, Ten Hagen KG, Tabak LA.

PLoS One. 2015 Jan 23;10(1):e0115861. doi: 10.1371/journal.pone.0115861. eCollection 2015.


Insufficient versican cleavage and Smad2 phosphorylation results in bicuspid aortic and pulmonary valves.

Dupuis LE, Osinska H, Weinstein MB, Hinton RB, Kern CB.

J Mol Cell Cardiol. 2013 Jul;60:50-9. doi: 10.1016/j.yjmcc.2013.03.010. Epub 2013 Mar 24.


Human semilunar cardiac valve remodeling by activated cells from fetus to adult: implications for postnatal adaptation, pathology, and tissue engineering.

Aikawa E, Whittaker P, Farber M, Mendelson K, Padera RF, Aikawa M, Schoen FJ.

Circulation. 2006 Mar 14;113(10):1344-52.


ADAM17 controls endochondral ossification by regulating terminal differentiation of chondrocytes.

Hall KC, Hill D, Otero M, Plumb DA, Froemel D, Dragomir CL, Maretzky T, Boskey A, Crawford HC, Selleri L, Goldring MB, Blobel CP.

Mol Cell Biol. 2013 Aug;33(16):3077-90. doi: 10.1128/MCB.00291-13. Epub 2013 Jun 3.


Migration of growth factor-stimulated epithelial and endothelial cells depends on EGFR transactivation by ADAM17.

Maretzky T, Evers A, Zhou W, Swendeman SL, Wong PM, Rafii S, Reiss K, Blobel CP.

Nat Commun. 2011;2:229. doi: 10.1038/ncomms1232.


Scleraxis is required for cell lineage differentiation and extracellular matrix remodeling during murine heart valve formation in vivo.

Levay AK, Peacock JD, Lu Y, Koch M, Hinton RB Jr, Kadler KE, Lincoln J.

Circ Res. 2008 Oct 24;103(9):948-56. doi: 10.1161/CIRCRESAHA.108.177238. Epub 2008 Sep 18.


Outflow tract cushions perform a critical valve-like function in the early embryonic heart requiring BMPRIA-mediated signaling in cardiac neural crest.

Nomura-Kitabayashi A, Phoon CK, Kishigami S, Rosenthal J, Yamauchi Y, Abe K, Yamamura K, Samtani R, Lo CW, Mishina Y.

Am J Physiol Heart Circ Physiol. 2009 Nov;297(5):H1617-28. doi: 10.1152/ajpheart.00304.2009. Epub 2009 Aug 28.


Deletion of Cdc42 enhances ADAM17-mediated vascular endothelial growth factor receptor 2 shedding and impairs vascular endothelial cell survival and vasculogenesis.

Jin Y, Liu Y, Lin Q, Li J, Druso JE, Antonyak MA, Meininger CJ, Zhang SL, Dostal DE, Guan JL, Cerione RA, Peng X.

Mol Cell Biol. 2013 Nov;33(21):4181-97. doi: 10.1128/MCB.00650-13. Epub 2013 Aug 26.


Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis.

MacGrogan D, D'Amato G, Travisano S, Martinez-Poveda B, Luxán G, Del Monte-Nieto G, Papoutsi T, Sbroggio M, Bou V, Gomez-Del Arco P, Gómez MJ, Zhou B, Redondo JM, Jiménez-Borreguero LJ, de la Pompa JL.

Circ Res. 2016 May 13;118(10):1480-97. doi: 10.1161/CIRCRESAHA.115.308077. Epub 2016 Apr 7.


Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves.

Chakraborty S, Wirrig EE, Hinton RB, Merrill WH, Spicer DB, Yutzey KE.

Dev Biol. 2010 Nov 1;347(1):167-79. doi: 10.1016/j.ydbio.2010.08.021. Epub 2010 Sep 6.


Lung cancer-derived galectin-1 enhances tumorigenic potentiation of tumor-associated dendritic cells by expressing heparin-binding EGF-like growth factor.

Kuo PL, Huang MS, Cheng DE, Hung JY, Yang CJ, Chou SH.

J Biol Chem. 2012 Mar 23;287(13):9753-64. doi: 10.1074/jbc.M111.321190. Epub 2012 Jan 30.


[Physiological significance and regulation of ectodomain shedding of HB-EGF].

Iwamoto R.

Tanpakushitsu Kakusan Koso. 2009 Oct;54(13):1722-7. Review. Japanese. No abstract available.


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