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Items: 1 to 20 of 135

1.

A PKS/NRPS/FAS hybrid gene cluster from Serratia plymuthica RVH1 encoding the biosynthesis of three broad spectrum, zeamine-related antibiotics.

Masschelein J, Mattheus W, Gao LJ, Moons P, Van Houdt R, Uytterhoeven B, Lamberigts C, Lescrinier E, Rozenski J, Herdewijn P, Aertsen A, Michiels C, Lavigne R.

PLoS One. 2013;8(1):e54143. doi: 10.1371/journal.pone.0054143. Epub 2013 Jan 17.

2.

A nonribosomal peptide synthase containing a stand-alone condensation domain is essential for phytotoxin zeamine biosynthesis.

Cheng Y, Liu X, An S, Chang C, Zou Y, Huang L, Zhong J, Liu Q, Jiang Z, Zhou J, Zhang LH.

Mol Plant Microbe Interact. 2013 Nov;26(11):1294-301. doi: 10.1094/MPMI-04-13-0098-R.

3.

The zeamine antibiotics affect the integrity of bacterial membranes.

Masschelein J, Clauwers C, Stalmans K, Nuyts K, De Borggraeve W, Briers Y, Aertsen A, Michiels CW, Lavigne R.

Appl Environ Microbiol. 2015 Feb;81(3):1139-46. doi: 10.1128/AEM.03146-14. Epub 2014 Dec 1.

5.

13C labeling reveals multiple amination reactions in the biosynthesis of a novel polyketide polyamine antibiotic zeamine from Dickeya zeae.

Wu J, Zhang HB, Xu JL, Cox RJ, Simpson TJ, Zhang LH.

Chem Commun (Camb). 2010 Jan 14;46(2):333-5. doi: 10.1039/b916307g. Epub 2009 Nov 13.

PMID:
20024369
6.
7.

A hybrid NRPS-PKS gene cluster related to the bleomycin family of antitumor antibiotics in Alteromonas macleodii strains.

Mizuno CM, Kimes NE, López-Pérez M, Ausó E, Rodriguez-Valera F, Ghai R.

PLoS One. 2013 Sep 19;8(9):e76021. doi: 10.1371/journal.pone.0076021. eCollection 2013.

8.

Bacteria of the Roseobacter clade show potential for secondary metabolite production.

Martens T, Gram L, Grossart HP, Kessler D, Müller R, Simon M, Wenzel SC, Brinkhoff T.

Microb Ecol. 2007 Jul;54(1):31-42. Epub 2007 Mar 10.

PMID:
17351813
9.

Biosynthesis of the acetyl-CoA carboxylase-inhibiting antibiotic, andrimid in Serratia is regulated by Hfq and the LysR-type transcriptional regulator, AdmX.

Matilla MA, Nogellova V, Morel B, Krell T, Salmond GP.

Environ Microbiol. 2016 Nov;18(11):3635-3650. doi: 10.1111/1462-2920.13241. Epub 2016 May 25.

10.

Identification and characterization of the biosynthetic gene cluster of divergolides from Streptomyces sp. W112.

Li SR, Zhao GS, Sun MW, He HG, Wang HX, Li YY, Lu CH, Shen YM.

Gene. 2014 Jul 1;544(1):93-9. doi: 10.1016/j.gene.2014.04.052. Epub 2014 Apr 24.

PMID:
24768719
11.

In Vitro Investigation of Crosstalk between Fatty Acid and Polyketide Synthases in the Andrimid Biosynthetic Assembly Line.

Ishikawa F, Sugimoto H, Kakeya H.

Chembiochem. 2016 Nov 17;17(22):2137-2142. doi: 10.1002/cbic.201600410. Epub 2016 Oct 11.

PMID:
27598417
12.

The broad-spectrum antibiotic, zeamine, kills the nematode worm Caenorhabditis elegans.

Hellberg JE, Matilla MA, Salmond GP.

Front Microbiol. 2015 Feb 26;6:137. doi: 10.3389/fmicb.2015.00137. eCollection 2015.

13.

Albicidin pathotoxin produced by Xanthomonas albilineans is encoded by three large PKS and NRPS genes present in a gene cluster also containing several putative modifying, regulatory, and resistance genes.

Royer M, Costet L, Vivien E, Bes M, Cousin A, Damais A, Pieretti I, Savin A, Megessier S, Viard M, Frutos R, Gabriel DW, Rott PC.

Mol Plant Microbe Interact. 2004 Apr;17(4):414-27.

14.

Nostophycin biosynthesis is directed by a hybrid polyketide synthase-nonribosomal peptide synthetase in the toxic cyanobacterium Nostoc sp. strain 152.

Fewer DP, Osterholm J, Rouhiainen L, Jokela J, Wahlsten M, Sivonen K.

Appl Environ Microbiol. 2011 Nov;77(22):8034-40. doi: 10.1128/AEM.05993-11. Epub 2011 Sep 23.

16.

Characterization of the biosynthetic gene cluster for maklamicin, a spirotetronate-class antibiotic of the endophytic Micromonospora sp. NBRC 110955.

Daduang R, Kitani S, Hashimoto J, Thamchaipenet A, Igarashi Y, Shin-ya K, Ikeda H, Nihira T.

Microbiol Res. 2015 Nov;180:30-9. doi: 10.1016/j.micres.2015.07.003. Epub 2015 Jul 22.

17.

A single Sfp-type phosphopantetheinyl transferase plays a major role in the biosynthesis of PKS and NRPS derived metabolites in Streptomyces ambofaciens ATCC23877.

Bunet R, Riclea R, Laureti L, Hôtel L, Paris C, Girardet JM, Spiteller D, Dickschat JS, Leblond P, Aigle B.

PLoS One. 2014 Jan 31;9(1):e87607. doi: 10.1371/journal.pone.0087607. eCollection 2014.

18.

The Serratia gene cluster encoding biosynthesis of the red antibiotic, prodigiosin, shows species- and strain-dependent genome context variation.

Harris AK, Williamson NR, Slater H, Cox A, Abbasi S, Foulds I, Simonsen HT, Leeper FJ, Salmond GP.

Microbiology. 2004 Nov;150(Pt 11):3547-60.

PMID:
15528645
19.

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