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Items: 1 to 20 of 122

1.

Telomerase reverse transcriptase synergizes with calorie restriction to increase health span and extend mouse longevity.

Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA.

PLoS One. 2013;8(1):e53760. doi: 10.1371/journal.pone.0053760. Epub 2013 Jan 22.

2.

The rate of increase of short telomeres predicts longevity in mammals.

Vera E, Bernardes de Jesus B, Foronda M, Flores JM, Blasco MA.

Cell Rep. 2012 Oct 25;2(4):732-7. doi: 10.1016/j.celrep.2012.08.023. Epub 2012 Sep 27.

3.

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.

Strong MA, Vidal-Cardenas SL, Karim B, Yu H, Guo N, Greider CW.

Mol Cell Biol. 2011 Jun;31(12):2369-79. doi: 10.1128/MCB.05312-11. Epub 2011 Apr 4.

4.

Antagonistic effects of telomerase on cancer and aging in K5-mTert transgenic mice.

González-Suárez E, Geserick C, Flores JM, Blasco MA.

Oncogene. 2005 Mar 24;24(13):2256-70.

PMID:
15688016
5.

Circadian clocks govern calorie restriction-mediated life span extension through BMAL1- and IGF-1-dependent mechanisms.

Patel SA, Chaudhari A, Gupta R, Velingkaar N, Kondratov RV.

FASEB J. 2016 Apr;30(4):1634-42. doi: 10.1096/fj.15-282475. Epub 2015 Dec 23.

6.

Telomerase redux: ready for prime time?

Larrick JW, Mendelsohn AR.

Rejuvenation Res. 2015 Apr;18(2):185-7. doi: 10.1089/rej.2015.1695.

PMID:
25790341
7.

A metabolic signature predicts biological age in mice.

Tomás-Loba A, Bernardes de Jesus B, Mato JM, Blasco MA.

Aging Cell. 2013 Feb;12(1):93-101. doi: 10.1111/acel.12025. Epub 2012 Dec 2.

8.

Comparative biology of mammalian telomeres: hypotheses on ancestral states and the roles of telomeres in longevity determination.

Gomes NM, Ryder OA, Houck ML, Charter SJ, Walker W, Forsyth NR, Austad SN, Venditti C, Pagel M, Shay JW, Wright WE.

Aging Cell. 2011 Oct;10(5):761-8. doi: 10.1111/j.1474-9726.2011.00718.x. Epub 2011 Jun 1.

9.

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype.

Al-Ajmi N, Saretzki G, Miles C, Spyridopoulos I.

Exp Gerontol. 2014 Oct;58:113-9. doi: 10.1016/j.exger.2014.07.010. Epub 2014 Jul 17.

PMID:
25038516
10.

Premature aging in telomerase-deficient zebrafish.

Anchelin M, Alcaraz-Pérez F, Martínez CM, Bernabé-García M, Mulero V, Cayuela ML.

Dis Model Mech. 2013 Sep;6(5):1101-12. doi: 10.1242/dmm.011635. Epub 2013 Jun 5.

11.

Longevity, stress response, and cancer in aging telomerase-deficient mice.

Rudolph KL, Chang S, Lee HW, Blasco M, Gottlieb GJ, Greider C, DePinho RA.

Cell. 1999 Mar 5;96(5):701-12.

12.

Ectopic expression of telomerase safely increases health span and life span.

Mendelsohn AR, Larrick JW.

Rejuvenation Res. 2012 Aug;15(4):435-8. doi: 10.1089/rej.2012.1359.

PMID:
22877566
13.

An intact putative mouse telomerase essential N-terminal domain is necessary for proper telomere maintenance.

Rousseau P, Khondaker S, Zhu S, Lauzon C, Mai S, Autexier C.

Biol Cell. 2016 Apr;108(4):96-112. doi: 10.1111/boc.201500089. Epub 2016 Feb 18.

PMID:
26787169
14.

Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice.

Erdmann N, Liu Y, Harrington L.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6080-5. Epub 2004 Apr 12.

15.

Preferential maintenance of critically short telomeres in mammalian cells heterozygous for mTert.

Liu Y, Kha H, Ungrin M, Robinson MO, Harrington L.

Proc Natl Acad Sci U S A. 2002 Mar 19;99(6):3597-602.

16.

Caloric restriction and the aging process: a critique.

Sohal RS, Forster MJ.

Free Radic Biol Med. 2014 Aug;73:366-82. doi: 10.1016/j.freeradbiomed.2014.05.015. Epub 2014 Jun 2. Review.

17.

Constitutive telomerase expression promotes mammary carcinomas in aging mice.

Artandi SE, Alson S, Tietze MK, Sharpless NE, Ye S, Greenberg RA, Castrillon DH, Horner JW, Weiler SR, Carrasco RD, DePinho RA.

Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):8191-6. Epub 2002 May 28.

18.

Zinc finger protein 637 protects cells against oxidative stress-induced premature senescence by mTERT-mediated telomerase activity and telomere maintenance.

Gao B, Li K, Wei YY, Zhang J, Li J, Zhang L, Gao JP, Li YY, Huang LG, Lin P, Wei YQ.

Cell Death Dis. 2014 Jul 17;5:e1334. doi: 10.1038/cddis.2014.298.

19.

Disease states associated with telomerase deficiency appear earlier in mice with short telomeres.

Herrera E, Samper E, Martín-Caballero J, Flores JM, Lee HW, Blasco MA.

EMBO J. 1999 Jun 1;18(11):2950-60.

20.

Telomerase is required for zebrafish lifespan.

Henriques CM, Carneiro MC, Tenente IM, Jacinto A, Ferreira MG.

PLoS Genet. 2013;9(1):e1003214. doi: 10.1371/journal.pgen.1003214. Epub 2013 Jan 17. Erratum in: PLoS Genet. 2017 Mar 13;13(3):e1006652.

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