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Items: 1 to 20 of 91

1.

Inhibition of 72 kDa inositol polyphosphate 5-phosphatase E improves insulin signal transduction in diet-induced obesity.

Bertelli DF, Coope A, Caricilli AM, Prada PO, Saad MJ, Velloso LA, Araujo EP.

J Endocrinol. 2013 Apr 15;217(2):131-40. doi: 10.1530/JOE-12-0562.

2.

Phosphoinositide-specific inositol polyphosphate 5-phosphatase IV inhibits inositide trisphosphate accumulation in hypothalamus and regulates food intake and body weight.

Bertelli DF, Araújo EP, Cesquini M, Stoppa GR, Gasparotto-Contessotto M, Toyama MH, Felix JV, Carvalheira JB, Michelini LC, Chiavegatto S, Boschero AC, Saad MJ, Lopes-Cendes I, Velloso LA.

Endocrinology. 2006 Nov;147(11):5385-99.

PMID:
16916951
3.

Reduction of hypothalamic protein tyrosine phosphatase improves insulin and leptin resistance in diet-induced obese rats.

Picardi PK, Calegari VC, Prada PO, Moraes JC, Araújo E, Marcondes MC, Ueno M, Carvalheira JB, Velloso LA, Saad MJ.

Endocrinology. 2008 Aug;149(8):3870-80. doi: 10.1210/en.2007-1506. Erratum in: Endocrinology. 2013 Apr;154(4):1667. Prada, Patrícia de Oliveira [corrected to Prada, Patricia Oliveira].

4.

L-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity.

Prada PO, Hirabara SM, de Souza CT, Schenka AA, Zecchin HG, Vassallo J, Velloso LA, Carneiro E, Carvalheira JB, Curi R, Saad MJ.

Diabetologia. 2007 Sep;50(9):1949-59.

PMID:
17604977
5.

Relationship of p53 accumulation in peripheral tissues of high-fat diet-induced obese rats with decrease in metabolic and oncogenic signaling of insulin.

Homayounfar R, Jeddi-Tehrani M, Cheraghpour M, Ghorbani A, Zand H.

Gen Comp Endocrinol. 2015 Apr 1;214:134-9. doi: 10.1016/j.ygcen.2014.06.029.

PMID:
25016051
6.

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice.

Carvalho BM, Guadagnini D, Tsukumo DM, Schenka AA, Latuf-Filho P, Vassallo J, Dias JC, Kubota LT, Carvalheira JB, Saad MJ.

Diabetologia. 2012 Oct;55(10):2823-34. doi: 10.1007/s00125-012-2648-4.

PMID:
22828956
7.

Chronic blockade of nitric oxide synthesis reduces adiposity and improves insulin resistance in high fat-induced obese mice.

Tsuchiya K, Sakai H, Suzuki N, Iwashima F, Yoshimoto T, Shichiri M, Hirata Y.

Endocrinology. 2007 Oct;148(10):4548-56.

PMID:
17584959
8.

The role of the inositol polyphosphate 5-phosphatases in cellular function and human disease.

Ooms LM, Horan KA, Rahman P, Seaton G, Gurung R, Kethesparan DS, Mitchell CA.

Biochem J. 2009 Apr 1;419(1):29-49. doi: 10.1042/BJ20081673. Review.

PMID:
19272022
9.

IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity.

Weissmann L, Quaresma PG, Santos AC, de Matos AH, Pascoal VD, Zanotto TM, Castro G, Guadagnini D, da Silva JM, Velloso LA, Bittencourt JC, Lopes-Cendes I, Saad MJ, Prada PO.

Diabetes. 2014 Oct;63(10):3334-45. doi: 10.2337/db13-1817.

10.

Antisense oligonucleotides against the lipid phosphatase SHIP2 improve muscle insulin sensitivity in a dietary rat model of the metabolic syndrome.

Buettner R, Ottinger I, Gerhardt-Salbert C, Wrede CE, Schölmerich J, Bollheimer LC.

Am J Physiol Endocrinol Metab. 2007 Jun;292(6):E1871-8.

11.

Phosphatidylinositol 3-phosphate [PtdIns3P] is generated at the plasma membrane by an inositol polyphosphate 5-phosphatase: endogenous PtdIns3P can promote GLUT4 translocation to the plasma membrane.

Kong AM, Horan KA, Sriratana A, Bailey CG, Collyer LJ, Nandurkar HH, Shisheva A, Layton MJ, Rasko JE, Rowe T, Mitchell CA.

Mol Cell Biol. 2006 Aug;26(16):6065-81.

12.

Targeting density-enhanced phosphatase-1 (DEP-1) with antisense oligonucleotides improves the metabolic phenotype in high-fat diet-fed mice.

Krüger J, Trappiel M, Dagnell M, Stawowy P, Meyborg H, Böhm C, Bhanot S, Ostman A, Kintscher U, Kappert K.

Cell Commun Signal. 2013 Jul 26;11:49. doi: 10.1186/1478-811X-11-49.

13.

Myostatin inhibition in muscle, but not adipose tissue, decreases fat mass and improves insulin sensitivity.

Guo T, Jou W, Chanturiya T, Portas J, Gavrilova O, McPherron AC.

PLoS One. 2009;4(3):e4937. doi: 10.1371/journal.pone.0004937.

14.

Fish oil and argan oil intake differently modulate insulin resistance and glucose intolerance in a rat model of dietary-induced obesity.

Samane S, Christon R, Dombrowski L, Turcotte S, Charrouf Z, Lavigne C, Levy E, Bachelard H, Amarouch H, Marette A, Haddad PS.

Metabolism. 2009 Jul;58(7):909-19. doi: 10.1016/j.metabol.2009.02.013.

PMID:
19394055
15.

Early and Long-term Undernutrition in Female Rats Exacerbates the Metabolic Risk Associated with Nutritional Rehabilitation.

Lizárraga-Mollinedo E, Fernández-Millán E, García-San Frutos M, de Toro-Martín J, Fernández-Agulló T, Ros M, Álvarez C, Escrivá F.

J Biol Chem. 2015 Jul 31;290(31):19353-66. doi: 10.1074/jbc.M114.549204.

16.

Unconventional microarray design reveals the response to obesity is largely tissue specific: analysis of common and divergent responses to diet-induced obesity in insulin-sensitive tissues.

Lee RK, Hittel DS, Nyamandi VZ, Kang L, Soh J, Sensen CW, Shearer J.

Appl Physiol Nutr Metab. 2012 Apr;37(2):257-68. doi: 10.1139/h11-159.

PMID:
22452611
17.

Low-grade hypothalamic inflammation leads to defective thermogenesis, insulin resistance, and impaired insulin secretion.

Arruda AP, Milanski M, Coope A, Torsoni AS, Ropelle E, Carvalho DP, Carvalheira JB, Velloso LA.

Endocrinology. 2011 Apr;152(4):1314-26. doi: 10.1210/en.2010-0659.

PMID:
21266511
18.

Consumption of a high-fat diet, but not regular endurance exercise training, regulates hypothalamic lipid accumulation in mice.

Borg ML, Omran SF, Weir J, Meikle PJ, Watt MJ.

J Physiol. 2012 Sep 1;590(17):4377-89. doi: 10.1113/jphysiol.2012.233288.

19.

Phosphatidylinositol 3,4,5-Trisphosphate Phosphatase SKIP Links Endoplasmic Reticulum Stress in Skeletal Muscle to Insulin Resistance.

Ijuin T, Hosooka T, Takenawa T.

Mol Cell Biol. 2015 Oct 19;36(1):108-18. doi: 10.1128/MCB.00921-15.

20.

Amylin improves the effect of leptin on insulin sensitivity in leptin-resistant diet-induced obese mice.

Kusakabe T, Ebihara K, Sakai T, Miyamoto L, Aotani D, Yamamoto Y, Yamamoto-Kataoka S, Aizawa-Abe M, Fujikura J, Hosoda K, Nakao K.

Am J Physiol Endocrinol Metab. 2012 Apr 15;302(8):E924-31. doi: 10.1152/ajpendo.00198.2011.

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