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Renal tubular NEDD4-2 deficiency causes NCC-mediated salt-dependent hypertension.

Ronzaud C, Loffing-Cueni D, Hausel P, Debonneville A, Malsure SR, Fowler-Jaeger N, Boase NA, Perrier R, Maillard M, Yang B, Stokes JB, Koesters R, Kumar S, Hummler E, Loffing J, Staub O.

J Clin Invest. 2013 Feb;123(2):657-65. doi: 10.1172/JCI61110. Epub 2013 Jan 25.


Ubiquitylation and the pathogenesis of hypertension.

Ellison DH.

J Clin Invest. 2013 Feb;123(2):546-8. doi: 10.1172/JCI66882. Epub 2013 Jan 25.


Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.

Al-Qusairi L, Basquin D, Roy A, Stifanelli M, Rajaram RD, Debonneville A, Nita I, Maillard M, Loffing J, Subramanya AR, Staub O.

Am J Physiol Renal Physiol. 2016 Aug 1;311(2):F330-42. doi: 10.1152/ajprenal.00002.2016. Epub 2016 Mar 23.


NEDD4-2 and salt-sensitive hypertension.

Rizzo F, Staub O.

Curr Opin Nephrol Hypertens. 2015 Mar;24(2):111-6. doi: 10.1097/MNH.0000000000000097. Review.


Salt-induced hypertension in a mouse model of Liddle syndrome is mediated by epithelial sodium channels in the brain.

Van Huysse JW, Amin MS, Yang B, Leenen FH.

Hypertension. 2012 Sep;60(3):691-6. doi: 10.1161/HYPERTENSIONAHA.112.193045. Epub 2012 Jul 16.


ENaC and ROMK activity are inhibited in the DCT2/CNT of TgWnk4PHAII mice.

Zhang C, Wang L, Su XT, Zhang J, Lin DH, Wang WH.

Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F682-F688. doi: 10.1152/ajprenal.00420.2016. Epub 2016 Nov 9.


The Ubiquitin Ligase Nedd4L Regulates the Na/K/2Cl Co-transporter NKCC1/SLC12A2 in the Colon.

Jiang C, Kawabe H, Rotin D.

J Biol Chem. 2017 Feb 24;292(8):3137-3145. doi: 10.1074/jbc.M116.770065. Epub 2017 Jan 13.


Inducible kidney-specific Sgk1 knockout mice show a salt-losing phenotype.

Faresse N, Lagnaz D, Debonneville A, Ismailji A, Maillard M, Fejes-Toth G, Náray-Fejes-Tóth A, Staub O.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F977-85. doi: 10.1152/ajprenal.00535.2011. Epub 2012 Feb 1.


In Liddle Syndrome, Epithelial Sodium Channel Is Hyperactive Mainly in the Early Part of the Aldosterone-Sensitive Distal Nephron.

Nesterov V, Krueger B, Bertog M, Dahlmann A, Palmisano R, Korbmacher C.

Hypertension. 2016 Jun;67(6):1256-62. doi: 10.1161/HYPERTENSIONAHA.115.07061.


Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.

Al-Qusairi L, Basquin D, Roy A, Rajaram RD, Maillard MP, Subramanya AR, Staub O.

J Am Soc Nephrol. 2017 Aug;28(8):2431-2442. doi: 10.1681/ASN.2016070732. Epub 2017 Mar 13.


Hrs controls sorting of the epithelial Na+ channel between endosomal degradation and recycling pathways.

Zhou R, Kabra R, Olson DR, Piper RC, Snyder PM.

J Biol Chem. 2010 Oct 1;285(40):30523-30. doi: 10.1074/jbc.M110.150755. Epub 2010 Jul 30.


Salt-sensitive hypertension and cardiac hypertrophy in mice deficient in the ubiquitin ligase Nedd4-2.

Shi PP, Cao XR, Sweezer EM, Kinney TS, Williams NR, Husted RF, Nair R, Weiss RM, Williamson RA, Sigmund CD, Snyder PM, Staub O, Stokes JB, Yang B.

Am J Physiol Renal Physiol. 2008 Aug;295(2):F462-70. doi: 10.1152/ajprenal.90300.2008. Epub 2008 Jun 4.


Nedd4-2 modulates renal Na+-Cl- cotransporter via the aldosterone-SGK1-Nedd4-2 pathway.

Arroyo JP, Lagnaz D, Ronzaud C, Vázquez N, Ko BS, Moddes L, Ruffieux-Daidié D, Hausel P, Koesters R, Yang B, Stokes JB, Hoover RS, Gamba G, Staub O.

J Am Soc Nephrol. 2011 Sep;22(9):1707-19. doi: 10.1681/ASN.2011020132. Epub 2011 Aug 18.


Decreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.

Hadchouel J, Soukaseum C, Büsst C, Zhou XO, Baudrie V, Zürrer T, Cambillau M, Elghozi JL, Lifton RP, Loffing J, Jeunemaitre X.

Proc Natl Acad Sci U S A. 2010 Oct 19;107(42):18109-14. doi: 10.1073/pnas.1006128107. Epub 2010 Oct 4.


Hypoxia-induced inhibition of epithelial Na(+) channels in the lung. Role of Nedd4-2 and the ubiquitin-proteasome pathway.

Gille T, Randrianarison-Pellan N, Goolaerts A, Dard N, Uzunhan Y, Ferrary E, Hummler E, Clerici C, Planès C.

Am J Respir Cell Mol Biol. 2014 Mar;50(3):526-37. doi: 10.1165/rcmb.2012-0518OC.


Altered renal expression of Na(+) transporters and ROMK in protein-deprived rats.

Ruete MC, Carrizo LC, Bocanegra MV, Vallés PG.

Nephron Physiol. 2009;111(3):p17-29. doi: 10.1159/000199462. Epub 2009 Feb 6.


Severe Salt-Losing Syndrome and Hyperkalemia Induced by Adult Nephron-Specific Knockout of the Epithelial Sodium Channel α-Subunit.

Perrier R, Boscardin E, Malsure S, Sergi C, Maillard MP, Loffing J, Loffing-Cueni D, Sørensen MV, Koesters R, Rossier BC, Frateschi S, Hummler E.

J Am Soc Nephrol. 2016 Aug;27(8):2309-18. doi: 10.1681/ASN.2015020154. Epub 2015 Dec 23.


Adult nephron-specific MR-deficient mice develop a severe renal PHA-1 phenotype.

Canonica J, Sergi C, Maillard M, Klusonova P, Odermatt A, Koesters R, Loffing-Cueni D, Loffing J, Rossier B, Frateschi S, Hummler E.

Pflugers Arch. 2016 May;468(5):895-908. doi: 10.1007/s00424-015-1785-2. Epub 2016 Jan 14.


Expression and phosphorylation of the Na+-Cl- cotransporter NCC in vivo is regulated by dietary salt, potassium, and SGK1.

Vallon V, Schroth J, Lang F, Kuhl D, Uchida S.

Am J Physiol Renal Physiol. 2009 Sep;297(3):F704-12. doi: 10.1152/ajprenal.00030.2009. Epub 2009 Jul 1.


NEDD4-2 (NEDD4L): the ubiquitin ligase for multiple membrane proteins.

Goel P, Manning JA, Kumar S.

Gene. 2015 Feb 15;557(1):1-10. doi: 10.1016/j.gene.2014.11.051. Epub 2014 Nov 26. Review.


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