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Items: 1 to 20 of 95

1.

Pancreatic digestive enzyme blockade in the intestine increases survival after experimental shock.

DeLano FA, Hoyt DB, Schmid-Schönbein GW.

Sci Transl Med. 2013 Jan 23;5(169):169ra11. doi: 10.1126/scitranslmed.3005046.

2.

Pancreatic digestive enzyme blockade in the small intestine prevents insulin resistance in hemorrhagic shock.

DeLano FA, Schmid-Schönbein GW.

Shock. 2014 Jan;41(1):55-61. doi: 10.1097/SHK.0000000000000048.

3.

Pancreatic enzymes generate cytotoxic mediators in the intestine.

Penn AH, Hugli TE, Schmid-Schönbein GW.

Shock. 2007 Mar;27(3):296-304.

PMID:
17304111
4.

Pancreatic proteases and inflammatory mediators in peritoneal fluid during splanchnic arterial occlusion and reperfusion.

Ishimaru K, Mitsuoka H, Unno N, Inuzuka K, Nakamura S, Schmid-Schönbein GW.

Shock. 2004 Nov;22(5):467-71.

PMID:
15489640
5.

Generation of in vivo activating factors in the ischemic intestine by pancreatic enzymes.

Mitsuoka H, Kistler EB, Schmid-Schonbein GW.

Proc Natl Acad Sci U S A. 2000 Feb 15;97(4):1772-7.

6.

An elementary analysis of physiologic shock and multi-organ failure: the autodigestion hypothesis.

Schmid-Schonbein GW, DeLano FA, Penn AH, Kistler E.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:3114-5. doi: 10.1109/EMBC.2012.6346623.

PMID:
23366584
7.

Autodigestion: Proteolytic Degradation and Multiple Organ Failure in Shock.

Altshuler AE, Kistler EB, Schmid-Schönbein GW.

Shock. 2016 May;45(5):483-9. doi: 10.1097/SHK.0000000000000544. Review.

8.

Impaired small-bowel barrier integrity in the presence of lumenal pancreatic digestive enzymes leads to circulatory shock.

Kistler EB, Alsaigh T, Chang M, Schmid-Schönbein GW.

Shock. 2012 Aug;38(3):262-7. doi: 10.1097/SHK.0b013e31825b1717.

9.

The intestine as source of cytotoxic mediators in shock: free fatty acids and degradation of lipid-binding proteins.

Penn AH, Schmid-Schönbein GW.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1779-92. doi: 10.1152/ajpheart.00902.2007. Epub 2008 Feb 8.

10.

Protease activity increases in plasma, peritoneal fluid, and vital organs after hemorrhagic shock in rats.

Altshuler AE, Penn AH, Yang JA, Kim GR, Schmid-Schönbein GW.

PLoS One. 2012;7(3):e32672. doi: 10.1371/journal.pone.0032672. Epub 2012 Mar 27.

11.

A journey with Tony Hugli up the inflammatory cascade towards the auto-digestion hypothesis.

Schmid-Schönbein GW.

Int Immunopharmacol. 2007 Dec 20;7(14):1845-51. Epub 2007 Aug 9. Review.

12.

The autodigestion hypothesis for shock and multi-organ failure.

Schmid-Schönbein GW, Chang M.

Ann Biomed Eng. 2014 Feb;42(2):405-14. doi: 10.1007/s10439-013-0891-6. Epub 2013 Aug 30. Review.

13.

Disruption of the mucosal barrier during gut ischemia allows entry of digestive enzymes into the intestinal wall.

Chang M, Kistler EB, Schmid-Schönbein GW.

Shock. 2012 Mar;37(3):297-305. doi: 10.1097/SHK.0b013e318240b59b.

14.
15.

Pancreatic protease inhibition during shock attenuates cell activation and peripheral inflammation.

Fitzal F, DeLano FA, Young C, Rosario HS, Schmid-Schönbein GW.

J Vasc Res. 2002 Jul-Aug;39(4):320-9.

PMID:
12187122
16.

Successful treatment with continuous enteral protease inhibitor in a patient with severe septic shock.

Lee YT, Wei J, Chuang YC, Chang CY, Chen IC, Weng CF, Schmid-Schönbein GW.

Transplant Proc. 2012 Apr;44(3):817-9. doi: 10.1016/j.transproceed.2012.03.032.

PMID:
22483504
17.

A new hypothesis for microvascular inflammation in shock and multiorgan failure: self-digestion by pancreatic enzymes.

Schmid-Schönbein GW, Hugli TE.

Microcirculation. 2005 Jan-Feb;12(1):71-82. Review.

PMID:
15804975
18.

Volatile Decay Products in Breath During Peritonitis Shock are Attenuated by Enteral Blockade of Pancreatic Digestive Proteases.

DeLano FA, Chow J, Schmid-Schönbein GW.

Shock. 2017 May 11. doi: 10.1097/SHK.0000000000000888. [Epub ahead of print]

PMID:
28498300
19.

The Autodigestion Hypothesis in Shock and Multi-Organ Failure: Degrading Protease Activity.

Schmid-Schönbein GW, Penn A, Kistler E.

Bol Soc Port Hemorreol Microcirc. 2011 Jul;26(3):6-15.

20.

Transmural intestinal wall permeability in severe ischemia after enteral protease inhibition.

Altshuler AE, Lamadrid I, Li D, Ma SR, Kurre L, Schmid-Schönbein GW, Penn AH.

PLoS One. 2014 May 7;9(5):e96655. doi: 10.1371/journal.pone.0096655. eCollection 2014.

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