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Items: 1 to 20 of 89

1.

Elucidating the biosynthetic pathway for vibralactone: a pancreatic lipase inhibitor with a fused bicyclic β-lactone.

Zhao PJ, Yang YL, Du L, Liu JK, Zeng Y.

Angew Chem Int Ed Engl. 2013 Feb 18;52(8):2298-302. doi: 10.1002/anie.201208182. Epub 2013 Jan 21. No abstract available. Erratum in: Angew Chem Int Ed Engl. 2013 May 10;52(20):5203. Du, Liangchen [corrected to Du, Liangcheng].

PMID:
23339115
2.

Vibralactone: a lipase inhibitor with an unusual fused beta-lactone produced by cultures of the basidiomycete Boreostereum vibrans.

Liu DZ, Wang F, Liao TG, Tang JG, Steglich W, Zhu HJ, Liu JK.

Org Lett. 2006 Dec 7;8(25):5749-52.

PMID:
17134263
3.

Ostalactones A-C, β- and ε-Lactones with Lipase Inhibitory Activity from the Cultured Basidiomycete Stereum ostrea.

Kang HS, Kim JP.

J Nat Prod. 2016 Dec 23;79(12):3148-3151. doi: 10.1021/acs.jnatprod.6b00647. Epub 2016 Dec 8.

PMID:
28006918
4.

Three new vibralactone-related compounds from cultures of Basidiomycete Boreostereum vibrans.

Wang GQ, Wei K, Zhang L, Li ZH, Wang QA, Liu JK.

J Asian Nat Prod Res. 2014;16(5):447-52. doi: 10.1080/10286020.2014.901312. Epub 2014 Apr 1.

PMID:
24684503
5.

Biosynthetic origin of a branched chain analogue of the lipase inhibitor, lipstatin.

Eisenreich W, Kupfer E, Stohler P, Weber W, Bacher A.

J Med Chem. 2003 Sep 11;46(19):4209-12.

PMID:
12954074
6.

Panclicins, novel pancreatic lipase inhibitors. II. Structural elucidation.

Yoshinari K, Aoki M, Ohtsuka T, Nakayama N, Itezono Y, Mutoh M, Watanabe J, Yokose K.

J Antibiot (Tokyo). 1994 Dec;47(12):1376-84.

7.

Derivatives of vibralactone from cultures of the basidiomycete Boreostereum vibrans.

Jiang MY, Wang F, Yang XL, Fang LZ, Dong ZJ, Zhu HJ, Liu JK.

Chem Pharm Bull (Tokyo). 2008 Sep;56(9):1286-8.

8.

Differential inhibition of HMG-CoA synthase and pancreatic lipase by the specific chiral isomers of beta-lactone DU-6622.

Tomoda H, Ohbayashi N, Kumagai H, Hashizume H, Sunazuka T, Omura S.

Biochem Biophys Res Commun. 1999 Nov 19;265(2):536-40.

PMID:
10558904
9.

Synthesis and biological investigation of the β-thiolactone and β-lactam analogs of tetrahydrolipstatin.

Aubry S, Aubert G, Cresteil T, Crich D.

Org Biomol Chem. 2012 Apr 7;10(13):2629-32. doi: 10.1039/c2ob06976h. Epub 2012 Feb 21.

PMID:
22354549
10.

Panclicins, novel pancreatic lipase inhibitors. I. Taxonomy, fermentation, isolation and biological activity.

Mutoh M, Nakada N, Matsukuma S, Ohshima S, Yoshinari K, Watanabe J, Arisawa M.

J Antibiot (Tokyo). 1994 Dec;47(12):1369-75.

11.

Synthesis of (+/-)-vibralactone.

Zhou Q, Snider BB.

Org Lett. 2008 Apr 3;10(7):1401-4. doi: 10.1021/ol800118c. Epub 2008 Mar 1.

12.

Biosynthetic precursors of the lipase inhibitor lipstatin.

Schuhr CA, Eisenreich W, Goese M, Stohler P, Weber W, Kupfer E, Bacher A.

J Org Chem. 2002 Apr 5;67(7):2257-62.

PMID:
11925237
13.

Unexpected Metabolic Versatility in a Combined Fungal Fomannoxin/Vibralactone Biosynthesis.

Schwenk D, Brandt P, Blanchette RA, Nett M, Hoffmeister D.

J Nat Prod. 2016 May 27;79(5):1407-14. doi: 10.1021/acs.jnatprod.6b00147. Epub 2016 Apr 22.

PMID:
27104866
14.

A 2-methyleneoxetane analog of orlistat demonstrating inhibition of porcine pancreatic lipase.

Dollinger LM, Howell AR.

Bioorg Med Chem Lett. 1998 Apr 21;8(8):977-8.

PMID:
9871523
15.

Vibralactones G-J from cultures of the basidiomycete Boreostereum vibrans.

Wang GQ, Wei K, Feng T, Li ZH, Zhang L, Wang QA, Liu JK.

J Asian Nat Prod Res. 2012;14(2):115-20. doi: 10.1080/10286020.2011.636037.

PMID:
22296151
16.

MNBA-mediated β-lactone formation: mechanistic studies and application for the asymmetric total synthesis of tetrahydrolipstatin.

Shiina I, Umezaki Y, Kuroda N, Iizumi T, Nagai S, Katoh T.

J Org Chem. 2012 Jun 1;77(11):4885-901. doi: 10.1021/jo300139r. Epub 2012 May 14.

PMID:
22553899
17.

Chirality of the gamma-lactones produced by Sporidiobolus salmonicolor grown in two different media.

Dufossé L, Féron G, Latrasse A, Guichard E, Spinnler HE.

Chirality. 1997;9(7):667-71.

PMID:
9366027
18.

The lipase inhibitor tetrahydrolipstatin binds covalently to the putative active site serine of pancreatic lipase.

Hadváry P, Sidler W, Meister W, Vetter W, Wolfer H.

J Biol Chem. 1991 Feb 5;266(4):2021-7.

19.
20.

On the inhibition of microbial lipases by tetrahydrolipstatin.

Haalck L, Spener F.

Methods Enzymol. 1997;286:252-63. No abstract available.

PMID:
9309654

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