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Reconstitution of functionally efficient SecA-dependent protein-conducting channels: transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels.

Hsieh YH, Zhang H, Wang H, Yang H, Jiang C, Sui SF, Tai PC.

Biochem Biophys Res Commun. 2013 Feb 15;431(3):388-92. doi: 10.1016/j.bbrc.2013.01.042. Epub 2013 Jan 18.


Dissecting structures and functions of SecA-only protein-conducting channels: ATPase, pore structure, ion channel activity, protein translocation, and interaction with SecYEG/SecDF•YajC.

Hsieh YH, Huang YJ, Zhang H, Liu Q, Lu Y, Yang H, Houghton J, Jiang C, Sui SF, Tai PC.

PLoS One. 2017 Jun 2;12(6):e0178307. doi: 10.1371/journal.pone.0178307. eCollection 2017.


SecA alone can promote protein translocation and ion channel activity: SecYEG increases efficiency and signal peptide specificity.

Hsieh YH, Zhang H, Lin BR, Cui N, Na B, Yang H, Jiang C, Sui SF, Tai PC.

J Biol Chem. 2011 Dec 30;286(52):44702-9. doi: 10.1074/jbc.M111.300111. Epub 2011 Oct 27.


Escherichia coli membranes depleted of SecYEG elicit SecA-dependent ion-channel activity but lose signal peptide specificity.

Lin BR, Hsieh YH, Jiang C, Tai PC.

J Membr Biol. 2012 Nov;245(11):747-57. doi: 10.1007/s00232-012-9477-8. Epub 2012 Aug 2.


Quaternary structure of SecA in solution and bound to SecYEG probed at the single molecule level.

Kusters I, van den Bogaart G, Kedrov A, Krasnikov V, Fulyani F, Poolman B, Driessen AJ.

Structure. 2011 Mar 9;19(3):430-9. doi: 10.1016/j.str.2010.12.016.


Mechanisms of Rose Bengal inhibition on SecA ATPase and ion channel activities.

Hsieh YH, Huang YJ, Jin JS, Yu L, Yang H, Jiang C, Wang B, Tai PC.

Biochem Biophys Res Commun. 2014 Nov 14;454(2):308-12. doi: 10.1016/j.bbrc.2014.10.070. Epub 2014 Oct 19.


Biphasic actions of SecA inhibitors on Prl/Sec suppressors: Possible physiological roles of SecA-only channels.

Hsieh YH, Zhang H, Jin J, Dai C, Jiang C, Wang B, Tai PC.

Biochem Biophys Res Commun. 2017 Jan 8;482(2):296-300. doi: 10.1016/j.bbrc.2016.11.057. Epub 2016 Nov 14.


Conformational state of the SecYEG-bound SecA probed by single tryptophan fluorescence spectroscopy.

Natale P, den Blaauwen T, van der Does C, Driessen AJ.

Biochemistry. 2005 May 3;44(17):6424-32.


Binding of SecA to the SecYEG complex accelerates the rate of nucleotide exchange on SecA.

Natale P, Swaving J, van der Does C, de Keyzer J, Driessen AJ.

J Biol Chem. 2004 Apr 2;279(14):13769-77. Epub 2004 Jan 13.


Phospholipids induce conformational changes of SecA to form membrane-specific domains: AFM structures and implication on protein-conducting channels.

You Z, Liao M, Zhang H, Yang H, Pan X, Houghton JE, Sui SF, Tai PC.

PLoS One. 2013 Aug 16;8(8):e72560. doi: 10.1371/journal.pone.0072560. eCollection 2013.


The oligomeric distribution of SecYEG is altered by SecA and translocation ligands.

Scheuring J, Braun N, Nothdurft L, Stumpf M, Veenendaal AK, Kol S, van der Does C, Driessen AJ, Weinkauf S.

J Mol Biol. 2005 Nov 25;354(2):258-71. Epub 2005 Oct 7.


Monitoring channel activities of proteoliposomes with SecA and Cx26 gap junction in single oocytes.

Hsieh YH, Zou J, Jin JS, Yang H, Chen Y, Jiang C, Yang J, Tai PC.

Anal Biochem. 2015 Jul 1;480:58-66. doi: 10.1016/j.ab.2015.04.005. Epub 2015 Apr 8.


The dispensability and requirement of SecA N-terminal aminoacyl residues for complementation, membrane binding, lipid-specific domains and channel activities.

Floyd JH, You Z, Hsieh YH, Ma Y, Yang H, Tai PC.

Biochem Biophys Res Commun. 2014 Oct 10;453(1):138-42. doi: 10.1016/j.bbrc.2014.09.080. Epub 2014 Sep 27.


Oligomeric states of the SecA and SecYEG core components of the bacterial Sec translocon.

Rusch SL, Kendall DA.

Biochim Biophys Acta. 2007 Jan;1768(1):5-12. Epub 2006 Aug 30. Review.


Effects of signal peptide and adenylate on the oligomerization and membrane binding of soluble SecA.

Shin JY, Kim M, Ahn T.

J Biochem Mol Biol. 2006 May 31;39(3):319-28.


Assembly of the translocase motor onto the preprotein-conducting channel.

Karamanou S, Bariami V, Papanikou E, Kalodimos CG, Economou A.

Mol Microbiol. 2008 Oct;70(2):311-22. doi: 10.1111/j.1365-2958.2008.06402.x. Epub 2008 Aug 22.


Lipids Activate SecA for High Affinity Binding to the SecYEG Complex.

Koch S, de Wit JG, Vos I, Birkner JP, Gordiichuk P, Herrmann A, van Oijen AM, Driessen AJ.

J Biol Chem. 2016 Oct 21;291(43):22534-22543. Epub 2016 Sep 9.

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