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High-resolution analysis and functional mapping of cleavage sites and substrate proteins of furin in the human proteome.

Shiryaev SA, Chernov AV, Golubkov VS, Thomsen ER, Chudin E, Chee MS, Kozlov IA, Strongin AY, Cieplak P.

PLoS One. 2013;8(1):e54290. doi: 10.1371/journal.pone.0054290. Epub 2013 Jan 15.


Substrate cleavage analysis of furin and related proprotein convertases. A comparative study.

Remacle AG, Shiryaev SA, Oh ES, Cieplak P, Srinivasan A, Wei G, Liddington RC, Ratnikov BI, Parent A, Desjardins R, Day R, Smith JW, Lebl M, Strongin AY.

J Biol Chem. 2008 Jul 25;283(30):20897-906. doi: 10.1074/jbc.M803762200. Epub 2008 May 27.


High resolution analysis of snake venom metalloproteinase (SVMP) peptide bond cleavage specificity using proteome based peptide libraries and mass spectrometry.

Paes Leme AF, Escalante T, Pereira JG, Oliveira AK, Sanchez EF, Gutiérrez JM, Serrano SM, Fox JW.

J Proteomics. 2011 Apr 1;74(4):401-10. doi: 10.1016/j.jprot.2010.12.002. Epub 2010 Dec 13.


Processing of alpha4 integrin by the proprotein convertases: histidine at position P6 regulates cleavage.

Bergeron E, Basak A, Decroly E, Seidah NG.

Biochem J. 2003 Jul 15;373(Pt 2):475-84.


New details of HCV NS3/4A proteinase functionality revealed by a high-throughput cleavage assay.

Shiryaev SA, Thomsen ER, Cieplak P, Chudin E, Cheltsov AV, Chee MS, Kozlov IA, Strongin AY.

PLoS One. 2012;7(4):e35759. doi: 10.1371/journal.pone.0035759. Epub 2012 Apr 27.


Importance of the P4' residue in human granzyme B inhibitors and substrates revealed by scanning mutagenesis of the proteinase inhibitor 9 reactive center loop.

Sun J, Whisstock JC, Harriott P, Walker B, Novak A, Thompson PE, Smith AI, Bird PI.

J Biol Chem. 2001 May 4;276(18):15177-84. Epub 2001 Feb 1.


Activity of human kallikrein-related peptidase 6 (KLK6) on substrates containing sequences of basic amino acids. Is it a processing protease?

Silva RN, Oliveira LC, Parise CB, Oliveira JR, Severino B, Corvino A, di Vaio P, Temussi PA, Caliendo G, Santagada V, Juliano L, Juliano MA.

Biochim Biophys Acta. 2017 May;1865(5):558-564. doi: 10.1016/j.bbapap.2017.02.017. Epub 2017 Feb 28.


Proteolytic cleavage of the rat heparan sulfate 6-O-endosulfatase SulfFP2 by furin-type proprotein convertases.

Nagamine S, Keino-Masu K, Shiomi K, Masu M.

Biochem Biophys Res Commun. 2010 Jan 1;391(1):107-12. doi: 10.1016/j.bbrc.2009.11.011. Epub 2009 Nov 10.


Limited redundancy of the proprotein convertase furin in mouse liver.

Roebroek AJ, Taylor NA, Louagie E, Pauli I, Smeijers L, Snellinx A, Lauwers A, Van de Ven WJ, Hartmann D, Creemers JW.

J Biol Chem. 2004 Dec 17;279(51):53442-50. Epub 2004 Oct 7.


A study of human furin specificity using synthetic peptides derived from natural substrates, and effects of potassium ions.

Izidoro MA, Gouvea IE, Santos JA, Assis DM, Oliveira V, Judice WA, Juliano MA, Lindberg I, Juliano L.

Arch Biochem Biophys. 2009 Jul 15;487(2):105-14. doi: 10.1016/ Epub 2009 May 27.


Implication of the proprotein convertases in iron homeostasis: proprotein convertase 7 sheds human transferrin receptor 1 and furin activates hepcidin.

Guillemot J, Canuel M, Essalmani R, Prat A, Seidah NG.

Hepatology. 2013 Jun;57(6):2514-24. doi: 10.1002/hep.26297. Epub 2013 May 15.


Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries.

Barré O, Dufour A, Eckhard U, Kappelhoff R, Béliveau F, Leduc R, Overall CM.

PLoS One. 2014 Sep 11;9(9):e105984. doi: 10.1371/journal.pone.0105984. eCollection 2014.


Autocatalytic activation of the furin zymogen requires removal of the emerging enzyme's N-terminus from the active site.

Gawlik K, Shiryaev SA, Zhu W, Motamedchaboki K, Desjardins R, Day R, Remacle AG, Stec B, Strongin AY.

PLoS One. 2009;4(4):e5031. doi: 10.1371/journal.pone.0005031. Epub 2009 Apr 7.


Snake venom serine proteinases specificity mapping by proteomic identification of cleavage sites.

Zelanis A, Huesgen PF, Oliveira AK, Tashima AK, Serrano SM, Overall CM.

J Proteomics. 2015 Jan 15;113:260-7. doi: 10.1016/j.jprot.2014.10.002. Epub 2014 Oct 14.


Targeting host cell furin proprotein convertases as a therapeutic strategy against bacterial toxins and viral pathogens.

Shiryaev SA, Remacle AG, Ratnikov BI, Nelson NA, Savinov AY, Wei G, Bottini M, Rega MF, Parent A, Desjardins R, Fugere M, Day R, Sabet M, Pellecchia M, Liddington RC, Smith JW, Mustelin T, Guiney DG, Lebl M, Strongin AY.

J Biol Chem. 2007 Jul 20;282(29):20847-53. Epub 2007 May 30.


Developing a powerful in silico tool for the discovery of novel caspase-3 substrates: a preliminary screening of the human proteome.

Ayyash M, Tamimi H, Ashhab Y.

BMC Bioinformatics. 2012 Jan 23;13:14. doi: 10.1186/1471-2105-13-14.


Site-specific cleavage of BMP4 by furin, PC6, and PC7.

Nelsen SM, Christian JL.

J Biol Chem. 2009 Oct 2;284(40):27157-66. doi: 10.1074/jbc.M109.028506. Epub 2009 Aug 3.

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