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Phosphorylation-mediated 14-3-3 protein binding regulates the function of the rho-specific guanine nucleotide exchange factor (RhoGEF) Syx.

Ngok SP, Geyer R, Kourtidis A, Storz P, Anastasiadis PZ.

J Biol Chem. 2013 Mar 1;288(9):6640-50. doi: 10.1074/jbc.M112.432682. Epub 2013 Jan 18.


VEGF and Angiopoietin-1 exert opposing effects on cell junctions by regulating the Rho GEF Syx.

Ngok SP, Geyer R, Liu M, Kourtidis A, Agrawal S, Wu C, Seerapu HR, Lewis-Tuffin LJ, Moodie KL, Huveldt D, Marx R, Baraban JM, Storz P, Horowitz A, Anastasiadis PZ.

J Cell Biol. 2012 Dec 24;199(7):1103-15. doi: 10.1083/jcb.201207009. Epub 2012 Dec 17.


The Rho guanine nucleotide exchange factor Syx regulates the balance of dia and ROCK activities to promote polarized-cancer-cell migration.

Dachsel JC, Ngok SP, Lewis-Tuffin LJ, Kourtidis A, Geyer R, Johnston L, Feathers R, Anastasiadis PZ.

Mol Cell Biol. 2013 Dec;33(24):4909-18. doi: 10.1128/MCB.00565-13. Epub 2013 Oct 14.


The RhoA GEF Syx is a target of Rnd3 and regulated via a Raf1-like ubiquitin-related domain.

Goh LL, Manser E.

PLoS One. 2010 Aug 25;5(8):e12409. doi: 10.1371/journal.pone.0012409.


Polarity-regulating kinase partitioning-defective 1b (PAR1b) phosphorylates guanine nucleotide exchange factor H1 (GEF-H1) to regulate RhoA-dependent actin cytoskeletal reorganization.

Yamahashi Y, Saito Y, Murata-Kamiya N, Hatakeyama M.

J Biol Chem. 2011 Dec 30;286(52):44576-84. doi: 10.1074/jbc.M111.267021. Epub 2011 Nov 9.


The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells.

Ernkvist M, Luna Persson N, Audebert S, Lecine P, Sinha I, Liu M, Schlueter M, Horowitz A, Aase K, Weide T, Borg JP, Majumdar A, Holmgren L.

Blood. 2009 Jan 1;113(1):244-53. doi: 10.1182/blood-2008-04-153874. Epub 2008 Sep 29.


TEM4 is a junctional Rho GEF required for cell-cell adhesion, monolayer integrity and barrier function.

Ngok SP, Geyer R, Kourtidis A, Mitin N, Feathers R, Der C, Anastasiadis PZ.

J Cell Sci. 2013 Aug 1;126(Pt 15):3271-7. doi: 10.1242/jcs.123869. Epub 2013 May 31.


Syx, a RhoA guanine exchange factor, is essential for angiogenesis in Vivo.

Garnaas MK, Moodie KL, Liu ML, Samant GV, Li K, Marx R, Baraban JM, Horowitz A, Ramchandran R.

Circ Res. 2008 Sep 26;103(7):710-6. doi: 10.1161/CIRCRESAHA.108.181388. Epub 2008 Aug 28.


RhoA inhibits neural differentiation in murine stem cells through multiple mechanisms.

Yang J, Wu C, Stefanescu I, Jakobsson L, Chervoneva I, Horowitz A.

Sci Signal. 2016 Jul 26;9(438):ra76. doi: 10.1126/scisignal.aaf0791.


The GTPase-deficient Rnd proteins are stabilized by their effectors.

Goh LL, Manser E.

J Biol Chem. 2012 Sep 7;287(37):31311-20. doi: 10.1074/jbc.M111.327056. Epub 2012 Jul 17.


p21-activated kinase 1 phosphorylates and regulates 14-3-3 binding to GEF-H1, a microtubule-localized Rho exchange factor.

Zenke FT, Krendel M, DerMardirossian C, King CC, Bohl BP, Bokoch GM.

J Biol Chem. 2004 Apr 30;279(18):18392-400. Epub 2004 Feb 17.


Guanine nucleotide exchange factor-H1 regulates cell migration via localized activation of RhoA at the leading edge.

Nalbant P, Chang YC, Birkenfeld J, Chang ZF, Bokoch GM.

Mol Biol Cell. 2009 Sep;20(18):4070-82. doi: 10.1091/mbc.E09-01-0041. Epub 2009 Jul 22.


Positive feedback between Dia1, LARG, and RhoA regulates cell morphology and invasion.

Kitzing TM, Sahadevan AS, Brandt DT, Knieling H, Hannemann S, Fackler OT, Grosshans J, Grosse R.

Genes Dev. 2007 Jun 15;21(12):1478-83.


Rab13-dependent trafficking of RhoA is required for directional migration and angiogenesis.

Wu C, Agrawal S, Vasanji A, Drazba J, Sarkaria S, Xie J, Welch CM, Liu M, Anand-Apte B, Horowitz A.

J Biol Chem. 2011 Jul 1;286(26):23511-20. doi: 10.1074/jbc.M111.245209. Epub 2011 May 4.


RHGF-2 is an essential Rho-1 specific RhoGEF that binds to the multi-PDZ domain scaffold protein MPZ-1 in Caenorhabditis elegans.

Lin L, Tran T, Hu S, Cramer T, Komuniecki R, Steven RM.

PLoS One. 2012;7(2):e31499. doi: 10.1371/journal.pone.0031499. Epub 2012 Feb 20.


Involvement of p114-RhoGEF and Lfc in Wnt-3a- and dishevelled-induced RhoA activation and neurite retraction in N1E-115 mouse neuroblastoma cells.

Tsuji T, Ohta Y, Kanno Y, Hirose K, Ohashi K, Mizuno K.

Mol Biol Cell. 2010 Oct 15;21(20):3590-600. doi: 10.1091/mbc.E10-02-0095. Epub 2010 Sep 1.

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